HCPCS Level II A4245: Alcohol Wipes, Per Box

HCPCS Level II code A4245 denotes a supply item: alcohol wipes packaged and billed per box. Nationally, supply codes like A4245 matter for facility and home-care billing because they affect consumable supplies, infection-control practices, and bundled supply reporting. This code is relevant across diverse care settings where antiseptic wipes are used for skin preparation, minor wound care, or equipment cleaning.

Key payers in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of what A4245 represents, how it is typically used in clinical workflows, and which payers commonly address reimbursement for supply items. The publication covers benchmark considerations for per-box supply billing, common billing modifiers and claim-line practices, and the clinical contexts in which alcohol wipes are most frequently documented.

The article provides a national perspective useful to billing professionals, revenue integrity teams, and supply chain managers seeking clarity on coding and payer coverage patterns for disposable antiseptic wipes. Data not available in the input will be noted where applicable.

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Billing Code Overview

HCPCS Level II code A4245 describes alcohol wipes, per box. The service represented is the provision or supply of boxed alcohol wipes intended for antiseptic skin preparation or surface cleansing. Typical sites of service include ambulatory clinics, hospitals, outpatient centers, long-term care settings, and home health environments where single-use antiseptic wipes are used as part of routine infection prevention and minor procedures.

Data not available in the input.

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HCPCS Level II A4245: Alcohol Wipes, Per Box

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Billing Code Overview

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Clinical & Coding Specifications

Clinical Context

A typical patient scenario involves a clinic nurse or medical assistant preparing the patient for a minor procedure, injection, or fingerstick glucose test requiring skin antisepsis. For example, an adult patient arrives to a primary care clinic for an intramuscular influenza vaccination. The medical assistant selects a prepackaged box of A4245 alcohol wipes, opens a single sterile wipe at the point of care, and cleans the injection site prior to administration. The workflow includes verifying patient identity, reviewing allergy history, preparing the vaccine and syringe, cleansing the skin with a single alcohol wipe from the box, allowing the site to dry, administering the injection, and documenting lot number, site, and that skin antisepsis was performed using an alcohol wipe from A4245.

Another common scenario is a phlebotomy encounter in an outpatient laboratory where a phlebotomist uses A4245 alcohol wipes from a box to cleanse venipuncture sites before blood draw. Typical settings include physician offices, outpatient clinics, ambulatory surgery centers, and outpatient laboratory collection sites. Documentation typically records the product used (box of alcohol wipes A4245), quantity dispensed or used, and the clinical indication (e.g., vaccination, injection, venipuncture, minor wound cleansing).

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`Z23`	Encounter for immunization	Common indication where `A4245` alcohol wipes are used to cleanse the injection site prior to vaccine administration.
`R68.89`	Other general symptoms and signs	Occasional general visit requiring injections or venipuncture where alcohol wipes are used; nonspecific presentation.
`S01.01XA`	Laceration without foreign body of scalp, initial encounter	Minor wound care and dressing where alcohol wipes are used for cleansing prior to repair.
`R79.89`	Other abnormal findings of blood chemistry	When abnormal labs prompt phlebotomy, `A4245` wipes are used during venipuncture.
`Z51.81`	Encounter for therapeutic drug level monitoring	Blood draws for drug levels require venipuncture site cleansing with alcohol wipes.
`T81.4XXA`	Infection following a procedure, initial encounter	Alcohol wipes are part of infection prevention measures during procedures; relevant to documentation when used.
`Z04.9`	Encounter for examination and observation, unspecified	General clinic encounters requiring injections or blood draws where alcohol wipes are employed.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`90471`	Immunization administration (single)	Alcohol wipes `A4245` are commonly used immediately before vaccine administration for skin antisepsis.
`36415`	Collection of venous blood by venipuncture	Phlebotomists use wipes from a box of `A4245` to cleanse the venipuncture site prior to specimen collection.
`96372`	Therapeutic, prophylactic, or diagnostic injection (subcutaneous or intramuscular)	Alcohol wipes are used to prepare the injection site when performing these injections.
`99070`	Supplies and materials (except devices), non-physician supplies, e.g., alcohol wipes, when requested by physician	`A4245` may be reported or referenced in policy discussions for supply billing; often payers bundle these small consumables into service charges.
`12001`	Simple repair of superficial wounds (minor)	For minor wound repair, alcohol wipes are used for site cleansing prior to closure and dressing preparation.

Related Modifiers

9 rows

Modifier	Description	When to Use
22	Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…	- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
53	Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…	- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
54	Modifier ‑54 (“Surgical care only”) is appended to a CPT surgical procedure when the reporting surgeon performs the intraoperative (surgical) component but does not furnish the preoperative and/or…	- Use modifier -54 when the reporting surgeon provided only the intraoperative (surgical) component of a procedure and preoperative and/or postoperative management has been or will be provided by…
55	Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…	- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
56	Modifier ‑56 indicates the reporting provider furnished only the preoperative management for a surgical procedure and did not perform the intraoperative or postoperative care. It is used in…	- Use Modifier -56 when a provider performs only the preoperative management in a split‑care situation (one physician manages preop care while a different physician performs the intraoperative…
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
78	CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…	- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
80	CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…	- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
363A00000X	Physician Assistant	A physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
207Q00000X	Family Medicine Physician	Family Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
3336C0002X	Clinic Pharmacy	A pharmacy in a clinic, emergency room or hospital (outpatient) that dispenses medications to patients for self-administration under the supervision o…
364S00000X	Clinical Nurse Specialist	A registered nurse who, through a graduate degree program in nursing, or through a formal post-basic education program or continuing education courses…
207RA0401X	Addiction Medicine (Internal Medicine) Physician	An internist doctor of osteopathy that specializes in the treatment of addiction disorders. A doctor of osteopathy that is board eligible/certified b…
222Q00000X	Developmental Therapist	A Developmental Therapist is a person qualified by completion of an approved program in Developmental Therapy and where applicable credentialed by the…
246QC2700X	Cytotechnology Specialist/Technologist	Technologists, Technicians & Other Technical Service Providers · Specialist/Technologist, Pathology
261QA0600X	Adult Day Care Clinic/Center	Ambulatory Health Care Facilities · Clinic/Center

Related Codes

HCPCS-A4206-STERILE-SYRINGE-1CC-NEEDLE

HCPCS Level II A4206: Sterile Syringe with Needle, 1 cc or Less

HCPCS-A4207-STERILE-2CC-SYRINGE-WITH-NEEDLE

HCPCS A4207: Syringe with Needle, Sterile 2 cc, Each

HCPCS-A4208-STERILE-3CC-SYRINGE-WITH-NEEDLE

HCPCS Level II A4208: Syringe with Needle, Sterile 3 cc, Each

HCPCS-A4209-STERILE-SYRINGE-WITH-NEEDLE-5CC-OR-GREATER

HCPCS A4209: Syringe with Needle, Sterile 5 cc or Greater

HCPCS-A4210-NEEDLE-FREE-INJECTION-DEVICE

HCPCS A4210: Needle-Free Injection Device, Single

HCPCS-A4211-SUPPLIES-SELF-ADMINISTERED-INJECTIONS

HCPCS A4211: Supplies for Self-Administered Injections

HCPCS-A4212-NON-CORING-NEEDLE-STYLET-CATHETER-ACCESS-SUPPLY

HCPCS Level II A4212: Non-coring Needle or Stylet with or without Catheter

HCPCS-A4213-STERILE-SYRINGE-20CC-OR-GREATER

HCPCS Level II A4213: Sterile Syringe, 20 cc or Greater

HCPCS-A4215-STERILE-NEEDLE-SINGLE-EACH

HCPCS Level II A4215: Sterile Needle, Single Use, Each

HCPCS-A4216-STERILE-DILUENT-FLUSH-10ML

HCPCS A4216: Sterile Diluent/Flush, 10 ml

Showing 1–10 of 633

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Clinical & Coding Specifications

Clinical Context

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`Z23`	Encounter for immunization	Common indication where `A4245` alcohol wipes are used to cleanse the injection site prior to vaccine administration.
`R68.89`	Other general symptoms and signs	Occasional general visit requiring injections or venipuncture where alcohol wipes are used; nonspecific presentation.
`S01.01XA`	Laceration without foreign body of scalp, initial encounter	Minor wound care and dressing where alcohol wipes are used for cleansing prior to repair.
`R79.89`	Other abnormal findings of blood chemistry	When abnormal labs prompt phlebotomy, `A4245` wipes are used during venipuncture.
`Z51.81`	Encounter for therapeutic drug level monitoring	Blood draws for drug levels require venipuncture site cleansing with alcohol wipes.
`T81.4XXA`	Infection following a procedure, initial encounter	Alcohol wipes are part of infection prevention measures during procedures; relevant to documentation when used.
`Z04.9`	Encounter for examination and observation, unspecified	General clinic encounters requiring injections or blood draws where alcohol wipes are employed.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`90471`	Immunization administration (single)	Alcohol wipes `A4245` are commonly used immediately before vaccine administration for skin antisepsis.
`36415`	Collection of venous blood by venipuncture	Phlebotomists use wipes from a box of `A4245` to cleanse the venipuncture site prior to specimen collection.
`96372`	Therapeutic, prophylactic, or diagnostic injection (subcutaneous or intramuscular)	Alcohol wipes are used to prepare the injection site when performing these injections.
`99070`	Supplies and materials (except devices), non-physician supplies, e.g., alcohol wipes, when requested by physician	`A4245` may be reported or referenced in policy discussions for supply billing; often payers bundle these small consumables into service charges.
`12001`	Simple repair of superficial wounds (minor)	For minor wound repair, alcohol wipes are used for site cleansing prior to closure and dressing preparation.

Related Modifiers

9 rows

Modifier	Description	When to Use
22	Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…	- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
53	Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…	- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
54	Modifier ‑54 (“Surgical care only”) is appended to a CPT surgical procedure when the reporting surgeon performs the intraoperative (surgical) component but does not furnish the preoperative and/or…	- Use modifier -54 when the reporting surgeon provided only the intraoperative (surgical) component of a procedure and preoperative and/or postoperative management has been or will be provided by…
55	Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…	- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
56	Modifier ‑56 indicates the reporting provider furnished only the preoperative management for a surgical procedure and did not perform the intraoperative or postoperative care. It is used in…	- Use Modifier -56 when a provider performs only the preoperative management in a split‑care situation (one physician manages preop care while a different physician performs the intraoperative…
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
78	CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…	- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
80	CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…	- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
363A00000X	Physician Assistant	A physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
207Q00000X	Family Medicine Physician	Family Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
3336C0002X	Clinic Pharmacy	A pharmacy in a clinic, emergency room or hospital (outpatient) that dispenses medications to patients for self-administration under the supervision o…
364S00000X	Clinical Nurse Specialist	A registered nurse who, through a graduate degree program in nursing, or through a formal post-basic education program or continuing education courses…
207RA0401X	Addiction Medicine (Internal Medicine) Physician	An internist doctor of osteopathy that specializes in the treatment of addiction disorders. A doctor of osteopathy that is board eligible/certified b…
222Q00000X	Developmental Therapist	A Developmental Therapist is a person qualified by completion of an approved program in Developmental Therapy and where applicable credentialed by the…
246QC2700X	Cytotechnology Specialist/Technologist	Technologists, Technicians & Other Technical Service Providers · Specialist/Technologist, Pathology
261QA0600X	Adult Day Care Clinic/Center	Ambulatory Health Care Facilities · Clinic/Center

Related Codes

HCPCS-A4206-STERILE-SYRINGE-1CC-NEEDLE

HCPCS Level II A4206: Sterile Syringe with Needle, 1 cc or Less

HCPCS-A4207-STERILE-2CC-SYRINGE-WITH-NEEDLE

HCPCS A4207: Syringe with Needle, Sterile 2 cc, Each

HCPCS-A4208-STERILE-3CC-SYRINGE-WITH-NEEDLE

HCPCS Level II A4208: Syringe with Needle, Sterile 3 cc, Each

HCPCS-A4209-STERILE-SYRINGE-WITH-NEEDLE-5CC-OR-GREATER

HCPCS A4209: Syringe with Needle, Sterile 5 cc or Greater

HCPCS-A4210-NEEDLE-FREE-INJECTION-DEVICE

HCPCS A4210: Needle-Free Injection Device, Single

HCPCS-A4211-SUPPLIES-SELF-ADMINISTERED-INJECTIONS

HCPCS A4211: Supplies for Self-Administered Injections

HCPCS-A4212-NON-CORING-NEEDLE-STYLET-CATHETER-ACCESS-SUPPLY

HCPCS Level II A4212: Non-coring Needle or Stylet with or without Catheter

HCPCS-A4213-STERILE-SYRINGE-20CC-OR-GREATER

HCPCS Level II A4213: Sterile Syringe, 20 cc or Greater

HCPCS-A4215-STERILE-NEEDLE-SINGLE-EACH

HCPCS Level II A4215: Sterile Needle, Single Use, Each

HCPCS-A4216-STERILE-DILUENT-FLUSH-10ML

HCPCS A4216: Sterile Diluent/Flush, 10 ml

Showing 1–10 of 633

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

HCPCS Level II A4245: Alcohol Wipes, Per Box

Sign up for hcpcs A4245 policy alerts

Billing Code Overview

HCPCS Level II A4245: Alcohol Wipes, Per Box

Sign up for hcpcs A4245 policy alerts

Billing Code Overview

Clinical & Coding Specifications

Clinical Context

Related Diagnoses

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

What does HCPCS A4245 represent and where is it typically used?

In what clinical workflows is A4245 most frequently used and how is its use documented?

How does A4245 relate to common CPT procedure codes and billing practices?

Which modifiers are relevant when reporting A4245 on a claim?

Which payers and stakeholders should be aware of A4245 reimbursement considerations?

References

Clinical & Coding Specifications

Clinical Context

Related Diagnoses

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

What does HCPCS A4245 represent and where is it typically used?

In what clinical workflows is A4245 most frequently used and how is its use documented?

How does A4245 relate to common CPT procedure codes and billing practices?

Which modifiers are relevant when reporting A4245 on a claim?

Which payers and stakeholders should be aware of A4245 reimbursement considerations?

References