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HCPCS Level II A4208: Syringe with Needle, Sterile 3 cc, Each

HCPCS Level II code A4208 denotes a sterile 3 cc syringe with attached needle supplied for single-use injection procedures. Nationally, this code matters because syringes are foundational to ambulatory and inpatient medication administration, immunization delivery, and various point-of-care procedures. Accurate coding affects supply-cost tracking, billing of ancillary supplies, and inventory management across care settings.

Key payers in the analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise explanation of what A4208 represents, its typical clinical uses, and where it is commonly administered. The publication outlines benchmarking context for supply billing, notes typical service lines and sites of care, and flags where policy updates or payer rules can impact coverage and billing workflows.

The content provides practical coding context for revenue-cycle staff, clinicians, and administrators seeking clarity on use of HCPCS Level II code A4208, plus guidance on where to look for payer-specific billing rules. Data not available in the input.

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Billing Code Overview

HCPCS Level II code A4208 describes a sterile syringe with needle, 3 cc, each. This item is a single-use medical supply intended for administration of injectable medications or vaccines.

Service Type: Supply — Injectable administration accessory

Typical Site of Service: Clinics, physician offices, hospitals, outpatient infusion centers, and other ambulatory care settings where injections or vaccinations are administered

Data not available in the input.

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HCPCS Level II A4208: Syringe with Needle, Sterile 3 cc, Each

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Billing Code Overview

HCPCS Level II code A4208 describes a sterile syringe with needle, 3 cc, each. This item is a single-use medical supply intended for administration of injectable medications or vaccines.

Service Type: Supply — Injectable administration accessory

Typical Site of Service: Clinics, physician offices, hospitals, outpatient infusion centers, and other ambulatory care settings where injections or vaccinations are administered

Data not available in the input.

Clinical & Coding Specifications

Clinical Context

A typical patient is an adult or pediatric outpatient presenting for an injection or medication administration that requires a sterile 3 cc syringe with attached needle. Common settings include ambulatory clinics, infusion centers, primary care offices, urgent care centers, school-based health services, and home health visits where a clinician or qualified practitioner prepares and administers subcutaneous, intramuscular, or intradermal medications or vaccines. The workflow includes medication order verification, aseptic preparation of the medication, drawing the prescribed volume into a sterile 3 cc syringe with needle (A4208), patient identification and consent, site selection and skin antisepsis, administration of the injection, disposal of sharps in an approved container, and documentation of medication, dose, lot number, route, site, and the device used in the medical record. Typical scenarios include vaccine administration, antibiotic or analgesic injections, insulin or biologic injections when a non-dedicated syringe is used by a clinician, tuberculin testing, and point-of-care procedures requiring precise small-volume aspiration and injection.

Coding Specifications

Modifier	Description	When to Use
`00`	No modifier	Use when no modifier applies to the supply billing.
`22`	Increased procedural services	When additional work beyond the usual is performed during the encounter that justifies increased payment for the service associated with the supply.
`23`	Unusual anesthesia	If general anesthesia is rendered unusually and the supply is billed in the same encounter (rare for this supply).
`52`	Reduced services	When the procedure associated with the syringe is partially reduced or discontinued but the supply was used.
`53`	Discontinued procedure	When the procedure was started but discontinued and the syringe was used prior to discontinuation.
`56`	Preoperative management only	If the billing relates only to preoperative preparation where the syringe was used for injections or tests.
`62`	Two surgeons	When two surgeons are involved in a procedure that used the syringe as part of operative care.
`78`	Return to the operating room for a related procedure during the postoperative period	If the patient returns to the OR and the syringe is used in that subsequent related procedure.
`80`	Assistant surgeon	When an assistant surgeon participates in a procedure where the syringe is used.
`AS`	Physician assistant, nurse practitioner, or clinical nurse specialist services for assistant at surgery	When an advanced practice clinician assists in surgery and the supply is billed in the surgical episode.
`NU`	New equipment	When the supply is newly purchased or provided as new equipment (rare for single-use syringes).
`QX`	Service furnished under a primary care exception	When the service is furnished by a practitioner billing under the primary care exception and the syringe is part of that service.
`RR`	Rehabilitation services, physical therapy/occupational therapy speech-language pathology	If the syringe is used as part of rehabilitation-related injections or administration during therapy sessions.

Taxonomy Code	Specialty	Notes
`207Q00000X`	Family Medicine	Frequently administers vaccines, immunizations, and injections using `3 cc` syringes.
`208D00000X`	General Internal Medicine	Common setting for medication injections, minor procedures, and immunizations.
`363A00000X`	Anesthesiology	Uses syringes for medication preparation and administration during procedures.
`208000000X`	Pediatrics	Administers immunizations and injections; uses appropriately sized syringes and needles.
`389200000X`	Nurse Practitioner	Performs medication administration, immunizations, and point-of-care injections in ambulatory and home settings.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`Z23`	Encounter for immunization	Vaccinations frequently require a sterile `3 cc` syringe for administration.
`J02.9`	Acute pharyngitis, unspecified	Clinician-administered intramuscular antibiotic injections in some cases use a `3 cc` syringe.
`L02.91`	Cutaneous abscess, unspecified site	Local anesthetic or aspiration during management may use a `3 cc` syringe.
`E11.9`	Type 2 diabetes mellitus without complications	Clinician-administered injections (non-insulin) or clinic procedures may use a `3 cc` syringe; insulin typically uses smaller syringes or pen devices.
`T81.4XXA`	Infection following a procedure, initial encounter	Syringes may be used for diagnostic aspiration, irrigation, or medication administration related to procedural infections.
`Z51.11`	Encounter for antineoplastic chemotherapy	Syringes may be used to draw or administer supportive medications or flush lines during chemotherapy encounters.
`R50.9`	Fever, unspecified	Injectable antipyretic or antibiotic administration in clinic settings may use a `3 cc` syringe.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`96372`	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscular	Commonly performed using a sterile `3 cc` syringe and needle for single injections administered by a clinician.
`90471`	Immunization administration (one vaccine) by injection (intramuscular, subcutaneous)	Vaccine administration often uses a `3 cc` syringe when appropriate for the vaccine volume.
`96365`	Intravenous infusion, for therapy, prophylaxis, or diagnosis; initial, up to 1 hour	Syringes are used for IV medication bolus preparation or flushing lines in conjunction with infusion services.
`10060`	Incision and drainage of abscess; simple or single	Minor procedures like I&D may use `3 cc` syringes for local anesthetic administration or aspiration.
`95115`	Professional services for allergen immunotherapy not including provision of allergenic extracts; single injection	Allergy injections administered by clinicians frequently use sterile `3 cc` syringes for small-volume allergen doses.

Related Codes

HCPCS-A4206-STERILE-SYRINGE-1CC-NEEDLE

HCPCS Level II A4206: Sterile Syringe with Needle, 1 cc or Less

HCPCS-A4207-STERILE-2CC-SYRINGE-WITH-NEEDLE

HCPCS A4207: Syringe with Needle, Sterile 2 cc, Each

HCPCS-A4209-STERILE-SYRINGE-WITH-NEEDLE-5CC-OR-GREATER

HCPCS A4209: Syringe with Needle, Sterile 5 cc or Greater

HCPCS-A4210-NEEDLE-FREE-INJECTION-DEVICE

HCPCS A4210: Needle-Free Injection Device, Single

HCPCS-A4211-SUPPLIES-SELF-ADMINISTERED-INJECTIONS

HCPCS A4211: Supplies for Self-Administered Injections

HCPCS-A4212-NON-CORING-NEEDLE-STYLET-CATHETER-ACCESS-SUPPLY

HCPCS Level II A4212: Non-coring Needle or Stylet with or without Catheter

HCPCS-A4213-STERILE-SYRINGE-20CC-OR-GREATER

HCPCS Level II A4213: Sterile Syringe, 20 cc or Greater

HCPCS-A4215-STERILE-NEEDLE-SINGLE-EACH

HCPCS Level II A4215: Sterile Needle, Single Use, Each

HCPCS-A4216-STERILE-DILUENT-FLUSH-10ML

HCPCS A4216: Sterile Diluent/Flush, 10 ml

HCPCS-A4217-STERILE-WATER-SALINE-500ML

HCPCS A4217: Sterile Water/Saline, 500 ml

Showing 1–10 of 633

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Jul 29, 2026.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Modifier	Description	When to Use
`00`	No modifier	Use when no modifier applies to the supply billing.
`22`	Increased procedural services	When additional work beyond the usual is performed during the encounter that justifies increased payment for the service associated with the supply.
`23`	Unusual anesthesia	If general anesthesia is rendered unusually and the supply is billed in the same encounter (rare for this supply).
`52`	Reduced services	When the procedure associated with the syringe is partially reduced or discontinued but the supply was used.
`53`	Discontinued procedure	When the procedure was started but discontinued and the syringe was used prior to discontinuation.
`56`	Preoperative management only	If the billing relates only to preoperative preparation where the syringe was used for injections or tests.
`62`	Two surgeons	When two surgeons are involved in a procedure that used the syringe as part of operative care.
`78`	Return to the operating room for a related procedure during the postoperative period	If the patient returns to the OR and the syringe is used in that subsequent related procedure.
`80`	Assistant surgeon	When an assistant surgeon participates in a procedure where the syringe is used.
`AS`	Physician assistant, nurse practitioner, or clinical nurse specialist services for assistant at surgery	When an advanced practice clinician assists in surgery and the supply is billed in the surgical episode.
`NU`	New equipment	When the supply is newly purchased or provided as new equipment (rare for single-use syringes).
`QX`	Service furnished under a primary care exception	When the service is furnished by a practitioner billing under the primary care exception and the syringe is part of that service.
`RR`	Rehabilitation services, physical therapy/occupational therapy speech-language pathology	If the syringe is used as part of rehabilitation-related injections or administration during therapy sessions.

Taxonomy Code	Specialty	Notes
`207Q00000X`	Family Medicine	Frequently administers vaccines, immunizations, and injections using `3 cc` syringes.
`208D00000X`	General Internal Medicine	Common setting for medication injections, minor procedures, and immunizations.
`363A00000X`	Anesthesiology	Uses syringes for medication preparation and administration during procedures.
`208000000X`	Pediatrics	Administers immunizations and injections; uses appropriately sized syringes and needles.
`389200000X`	Nurse Practitioner	Performs medication administration, immunizations, and point-of-care injections in ambulatory and home settings.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`Z23`	Encounter for immunization	Vaccinations frequently require a sterile `3 cc` syringe for administration.
`J02.9`	Acute pharyngitis, unspecified	Clinician-administered intramuscular antibiotic injections in some cases use a `3 cc` syringe.
`L02.91`	Cutaneous abscess, unspecified site	Local anesthetic or aspiration during management may use a `3 cc` syringe.
`E11.9`	Type 2 diabetes mellitus without complications	Clinician-administered injections (non-insulin) or clinic procedures may use a `3 cc` syringe; insulin typically uses smaller syringes or pen devices.
`T81.4XXA`	Infection following a procedure, initial encounter	Syringes may be used for diagnostic aspiration, irrigation, or medication administration related to procedural infections.
`Z51.11`	Encounter for antineoplastic chemotherapy	Syringes may be used to draw or administer supportive medications or flush lines during chemotherapy encounters.
`R50.9`	Fever, unspecified	Injectable antipyretic or antibiotic administration in clinic settings may use a `3 cc` syringe.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`96372`	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscular	Commonly performed using a sterile `3 cc` syringe and needle for single injections administered by a clinician.
`90471`	Immunization administration (one vaccine) by injection (intramuscular, subcutaneous)	Vaccine administration often uses a `3 cc` syringe when appropriate for the vaccine volume.
`96365`	Intravenous infusion, for therapy, prophylaxis, or diagnosis; initial, up to 1 hour	Syringes are used for IV medication bolus preparation or flushing lines in conjunction with infusion services.
`10060`	Incision and drainage of abscess; simple or single	Minor procedures like I&D may use `3 cc` syringes for local anesthetic administration or aspiration.
`95115`	Professional services for allergen immunotherapy not including provision of allergenic extracts; single injection	Allergy injections administered by clinicians frequently use sterile `3 cc` syringes for small-volume allergen doses.

Related Codes

HCPCS-A4206-STERILE-SYRINGE-1CC-NEEDLE

HCPCS Level II A4206: Sterile Syringe with Needle, 1 cc or Less

HCPCS-A4207-STERILE-2CC-SYRINGE-WITH-NEEDLE

HCPCS A4207: Syringe with Needle, Sterile 2 cc, Each

HCPCS-A4209-STERILE-SYRINGE-WITH-NEEDLE-5CC-OR-GREATER

HCPCS A4209: Syringe with Needle, Sterile 5 cc or Greater

HCPCS-A4210-NEEDLE-FREE-INJECTION-DEVICE

HCPCS A4210: Needle-Free Injection Device, Single

HCPCS-A4211-SUPPLIES-SELF-ADMINISTERED-INJECTIONS

HCPCS A4211: Supplies for Self-Administered Injections

HCPCS-A4212-NON-CORING-NEEDLE-STYLET-CATHETER-ACCESS-SUPPLY

HCPCS Level II A4212: Non-coring Needle or Stylet with or without Catheter

HCPCS-A4213-STERILE-SYRINGE-20CC-OR-GREATER

HCPCS Level II A4213: Sterile Syringe, 20 cc or Greater

HCPCS-A4215-STERILE-NEEDLE-SINGLE-EACH

HCPCS Level II A4215: Sterile Needle, Single Use, Each

HCPCS-A4216-STERILE-DILUENT-FLUSH-10ML

HCPCS A4216: Sterile Diluent/Flush, 10 ml

HCPCS-A4217-STERILE-WATER-SALINE-500ML

HCPCS A4217: Sterile Water/Saline, 500 ml

Showing 1–10 of 633

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Jul 29, 2026.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

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HCPCS Level II A4208: Syringe with Needle, Sterile 3 cc, Each

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Billing Code Overview

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HCPCS Level II A4208: Syringe with Needle, Sterile 3 cc, Each

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Billing Code Overview

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

References

HCPCS Level II A4208: Syringe with Needle, Sterile 3 cc, Each

Sign up for hcpcs A4208 policy alerts

Billing Code Overview

HCPCS Level II A4208: Syringe with Needle, Sterile 3 cc, Each

Sign up for hcpcs A4208 policy alerts

Billing Code Overview

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

What does HCPCS code A4208 represent and where is it typically used?

In what clinical scenarios and workflow steps is A4208 typically used?

Which CPT procedure codes commonly accompany billing for this syringe?

Do payers cover A4208 and are reimbursement rates provided?

Which modifiers might apply when billing A4208 and what do they indicate?

References

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

What does HCPCS code A4208 represent and where is it typically used?

In what clinical scenarios and workflow steps is A4208 typically used?

Which CPT procedure codes commonly accompany billing for this syringe?

Do payers cover A4208 and are reimbursement rates provided?

Which modifiers might apply when billing A4208 and what do they indicate?

References