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    v1.0.28
    OpenPayerBilling CodesBenign neoplasms, except benign neuroendocrine tumorsICD-10-CM d21-other-benign-soft-tissue-neoplasms
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    ICD-10-CM Code For Other Benign Neoplasms Of Connective And Other Soft Tissue: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group D21 includes benign neoplasms of connective and other soft tissues such as lipomas, fibromas, and similar nonmalignant soft-tissue tumors occurring in various anatomical sites. These ICD-10-CM diagnosis codes are used to document clinical scenarios involving localized, nonmetastasizing soft-tissue masses, capturing lesion location, size when documented, and any associated functional impact. Accurate coding within the ICD-10-CM D21 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM D21: Other Benign Neoplasms Of Connective And Other Soft Tissue Overview

    This group represents benign tumors arising from connective and other soft tissues such as fat, muscle, fibrous tissue, and vessels, excluding benign neuroendocrine tumors. It targets soft-tissue neoplasms across multiple anatomical sites and is used to classify nonmalignant growths that may cause mass effect or functional impairment. Accurate coding matters for proper documentation of clinical severity and for reimbursement alignment with services provided.

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    When to Use

    Use a code from this group when the clinical documentation specifies a benign soft-tissue neoplasm of connective or other soft tissue with localization documented. Select the code that reflects the documented anatomical site and any additional specificity provided in the medical record.

    ICD-10-CM Codes

    12 rows

    ICD-10-CM CodeDescription
    D21.0Benign neoplasm of connective and other soft tissue of head, face and neck
    D21.10Benign neoplasm of connective and other soft tissue of unspecified upper limb, including shoulder
    D21.11Benign neoplasm of connective and other soft tissue of right upper limb, including shoulder
    D21.12Benign neoplasm of connective and other soft tissue of left upper limb, including shoulder
    D21.20Benign neoplasm of connective and other soft tissue of unspecified lower limb, including hip
    D21.21Benign neoplasm of connective and other soft tissue of right lower limb, including hip
    D21.22Benign neoplasm of connective and other soft tissue of left lower limb, including hip
    D21.3Benign neoplasm of connective and other soft tissue of thorax
    D21.4Benign neoplasm of connective and other soft tissue of abdomen
    D21.5Benign neoplasm of connective and other soft tissue of pelvis
    D21.6Benign neoplasm of connective and other soft tissue of trunk, unspecified
    D21.9Benign neoplasm of connective and other soft tissue, unspecified

    DRG Codes

    3 rows

    DRG CodeDescription
    564Other Musculoskeletal System and Connective Tissue Diagnoses with MCC
    565Other Musculoskeletal System and Connective Tissue Diagnoses with CC
    566Other Musculoskeletal System and Connective Tissue Diagnoses without CC/MCC

    Related Codes

    D10-BENIGN-NEOPLASM-OF-MOUTH-AND-PHARYNX

    ICD-10-CM Code For Benign Neoplasm Of Mouth And Pharynx: Group Overview

    D11-BENIGN-NEOPLASM-MAJOR-SALIVARY-GLANDS

    ICD-10-CM Code For Benign Neoplasm Of Major Salivary Glands: Group Overview

    D12-BENIGN-NEOPLASM-COLON-RECTUM-ANUS

    ICD-10-CM Code For Benign Neoplasm Of Colon Rectum Anus And Anal Canal: Group Overview

    D13-BENIGN-NEOPLASM-OTHER-DIGESTIVE

    ICD-10-CM Code For Benign Neoplasm Of Other And Ill-Defined Parts Of Digestive System: Group Overview

    D14-BENIGN-MIDDLE-EAR-AND-RESPIRATORY-NEOPLASMS

    ICD-10-CM Code For Benign Neoplasm Of Middle Ear And Respiratory System: Group Overview

    D15-BENIGN-NEOPLASM-INTRATHORACIC-ORGANS

    ICD-10-CM Code For Benign Neoplasm Of Other And Unspecified Intrathoracic Organs: Group Overview

    D16-BENIGN-NEOPLASM-OF-BONE

    ICD-10-CM Code For Benign Neoplasm Of Bone And Articular Cartilage: Group Overview

    D17-BENIGN-LIPOMATOUS-NEOPLASM

    ICD-10-CM Code For Benign Lipomatous Neoplasm: Group Overview

    D18-HEMANGIOMA-AND-LYMPHANGIOMA

    ICD-10-CM Code For Hemangioma And Lymphangioma, Any Site: Group Overview

    D19-BENIGN-MESOTHELIAL-NEOPLASMS

    ICD-10-CM Code For Benign Neoplasm Of Mesothelial Tissue: Group Overview

    Showing 1–10 of 26

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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