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    v1.0.30
    OpenPayerBilling CodesOther Pathology and Laboratory ProceduresCPT cpt-89230-sweat-collection-by-iontophoresis
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    CPT 89230: Sweat Collection by Iontophoresis

    Medicare pays $3 on average nationally for this procedure.

    CPT code 89230 describes sweat collection by iontophoresis, a diagnostic procedure in which an analyst uses a mild electric current to drive a saline solution and induce localized sweating for subsequent laboratory analysis; this is a diagnostic sweat collection procedure typically performed in ambulatory clinic or outpatient laboratory settings and is used when chloride or other sweat electrolyte testing is required.

    For related coverage guidance, see recent payer policy updates: Oral Cancer Screening and Testing, RTM Testing for Alpha-1 Antitrypsin Deficiency, Cytochrome P450 Genotype-Guided Treatment Strategy Corporate Medical Policy.

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    Clinical & Coding Specifications

    Clinical Context

    A 6-year-old child with recurrent lower respiratory tract infections and failure to thrive is referred to a pediatric pulmonology clinic for evaluation of possible cystic fibrosis. After history, physical exam, and genetic testing are inconclusive or pending, the clinician orders a sweat chloride test. In the outpatient clinic, a trained analyst performs sweat collection by iontophoresis using pilocarpine and a mild electric current to stimulate localized sweating. The procedure typically occurs in an ambulatory clinic or hospital outpatient laboratory and takes approximately 30–60 minutes including site preparation, iontophoresis application, timed sweat collection, and documentation. A laboratory technologist or certified respiratory therapist prepares the collection sites (usually forearm), applies the iontophoresis electrodes, runs the current for the prescribed time, collects the sweat onto gauze or collection devices, measures the volume, and sends the specimen to the laboratory for chloride assay. Results are reported to the ordering clinician and documented in the medical record. The service is commonly billed when diagnostic clarification for cystic fibrosis or evaluation of unexplained hyponatremia, chronic cough, or failure to thrive is needed; it may be repeated when prior tests are indeterminate or to confirm newborn screening abnormalities.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    89230Sweat collection by iontophoresis (in the context of cystic fibrosis testing)Primary procedure for stimulating and collecting sweat for chloride analysis
    83020Hemoglobin; glycated (A1c)Not directly related; listed here for laboratory workflow contrast (Data not available in input)
    84132Chloride; sweatLaboratory assay that quantifies chloride concentration in collected sweat; typically performed after 89230
    81000Urinalysis, by dip stick or tablet reagentCommonly ordered in metabolic or dehydration evaluation when sweat testing is performed (clinical adjunct)
    99213Office or other outpatient visit, established patientTypical evaluation visit for ordering and reviewing results of the sweat test

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207Q00000X
    207RA0000X
    3336C0003X
    261QM0801X
    2086S0122X
    2083A0300X
    364SX0106X
    163WH0500X

    Related ICD-10-CM Codes

    28 rows

    ICD-10-CM CodeDescription
    B34.9Viral infection, unspecified
    E03.9Hypothyroidism, unspecified
    E10.9Type 1 diabetes mellitus without complications
    E11.9Type 2 diabetes mellitus without complications
    E66.9Obesity, unspecified
    E78.5Hyperlipidemia, unspecified
    E84.0Cystic fibrosis with pulmonary manifestations
    E84.11Meconium ileus in cystic fibrosis
    E84.19Cystic fibrosis with other intestinal manifestations
    E84.8Cystic fibrosis with other manifestations

    Showing 1–10 of 28

    Related Payer Policy Updates

    Specialty: Genetic & Molecular Testing1 / 3

    10 rows

    PolicyPayerEffective Date
    Oral Cancer Screening and TestingOscar Health2027-01-01
    RTM Testing for Alpha-1 Antitrypsin DeficiencyOscar Health2027-01-01
    Cytochrome P450 Genotype-Guided Treatment Strategy Corporate Medical Policybcbsvermont2027-01-01
    Carrier Testing Panels for Genetic Diseases (for Kentucky Only)UnitedHealthcare2026-10-01
    Genetic Testing for Neurological Disorders (for Kansas Only)UnitedHealthcare2026-10-01
    Genetic and Molecular TestingProvidence Health Plan2026-10-01
    Cell-Free Fetal DNA Testing (for Idaho Only)UnitedHealthcare2026-10-01
    Next Generation Sequencing for Minimal Residual Disease DetectionProvidence Health Plan2026-10-01
    Pharmacogenetic Panel Testing (for Kansas Only)UnitedHealthcare2026-10-01
    Non-Covered Genetic Panel TestsProvidence Health Plan2026-10-01

    Related Codes

    CPT-89049-CAFFEINE-HALOTHANE-CONTRACTURE-TEST-MH-SUSCEPTIBILITY

    CPT 89049: Caffeine-Halothane Contracture Test for Malignant Hyperthermia Susceptibility

    CPT-89050-CSF-JOINT-FLUID-CELL-COUNT

    CPT 89050: Cell Count of Miscellaneous Body Fluids (CSF, Joint Fluid)

    CPT-89051-BODY-FLUID-CELL-COUNT-DIFFERENTIAL-NON-BLOOD

    CPT 89051: Body Fluid Cell Count with Differential

    CPT-89055-STOOL-LEUKOCYTE-ANALYSIS

    CPT 89055: Stool Leukocyte Test, Technical Component

    CPT-89060-MICROSCOPIC-CRYSTAL-ANALYSIS-TISSUE-BODY-FLUID

    CPT 89060: Crystal Analysis by Light Microscopy

    CPT-89125-FAT-STAIN-STOOL-URINE-RESPIRATORY-SPECIMEN

    CPT 89125: Fat Stain of Feces, Urine, or Respiratory Secretions

    CPT-89160-FECAL-MUSCLE-FIBER-MICROSCOPY

    CPT 89160: Fecal Microscopic Examination for Muscle Fibers

    CPT-89190-NASAL-SMEAR-EOSINOPHIL-ANALYSIS

    CPT 89190: Nasal Smear Examination for Eosinophils

    CPT-89220-ASSISTED-SPUTUM-INDUCTION-AEROSOL-MIST

    CPT 89220: Induced Sputum Collection by Aerosol Mist

    CPT-89240-UNLISTED-PATHOLOGY-PROCEDURE

    CPT 89240: Unlisted Pathology Procedure

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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