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    v1.0.30
    OpenPayerBilling CodesOther Pathology and Laboratory ProceduresCPT cpt-89220-assisted-sputum-induction-aerosol-mist
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    CPT 89220: Induced Sputum Collection by Aerosol Mist

    Medicare pays $22 on average nationally for this procedure.

    CPT code 89220 describes an analyst-performed induced sputum collection using an aerosol mist to assist a patient in producing a sputum sample; the service is a specimen collection procedure typically performed in outpatient clinics, pulmonary function labs, or other ambulatory care settings where respiratory diagnostic samples are obtained.

    For related coverage guidance, see recent payer policy updates: Oral Cancer Screening and Testing, RTM Testing for Alpha-1 Antitrypsin Deficiency, Cytochrome P450 Genotype-Guided Treatment Strategy Corporate Medical Policy.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 68-year-old male with a history of chronic obstructive pulmonary disease (COPD) and a recent productive cough presents to an outpatient pulmonary function laboratory for microbiologic evaluation of suspected bacterial lower respiratory tract infection. Sputum expectoration is limited by a weak cough, so a trained laboratory analyst performs an aerosolized hypertonic saline induction to stimulate deep sputum production. The analyst administers the aerosol mist, coaches the patient through inhalation and coughing, collects the specimen into a sterile container, labels it, and documents the procedure as a separate service. The sample is sent to the microbiology lab for Gram stain, culture and sensitivity, and possibly mycobacterial testing if clinically indicated. Typical sites of service include hospital outpatient departments, ambulatory surgery centers, pulmonary function laboratories, and outpatient clinics. The service is billed only when the analyst performs aerosol induction as a distinct procedure separate from clinician evaluation or specimen testing.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    89220Sputum induction by aerosol mist performed by an analyst (separate procedure)The primary code describing aerosol-assisted sputum collection when performed as a distinct service.
    87070Culture, bacterial; any other source except urine, blood or stool, aerobic, bacterial isolateCommonly used for bacterial culture of induced sputum to identify pathogens and guide therapy.
    87205Smear, primary source with interpretation; Gram or Giemsa stain for bacteria, fungi, or parasitesUsed for Gram staining of the induced sputum to provide rapid preliminary identification of organisms.
    87077Culture, bacterial; with isolation and presumptive identification of each organismMay be reported when induced sputum yields isolates requiring identification and preliminary reporting.
    87520Infectious agent detection by nucleic acid (DNA or RNA), multiple organisms or method; respiratory viral panelOften performed on induced sputum to detect viral pathogens as part of a respiratory infection workup.
    87116Fungal culture, sputum (for mycobacteria refer to mycobacterial cultures)Performed when fungal infection is suspected; induced sputum can be sent for fungal culture in appropriate cases.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207Q00000X
    207R00000X
    363L00000X
    2084P0800X
    207L00000X
    226300000X
    374J00000X
    363LC0200X

    Related ICD-10-CM Codes

    26 rows

    ICD-10-CM CodeDescription
    A41.9Sepsis, unspecified organism
    B34.9Viral infection, unspecified
    J12.9Viral pneumonia, unspecified
    J13Pneumonia due to Streptococcus pneumoniae
    J15.9Unspecified bacterial pneumonia
    J16.8Pneumonia due to other specified infectious organisms
    J18.9Pneumonia, unspecified organism
    J20.9Acute bronchitis, unspecified
    J22Unspecified acute lower respiratory infection
    J43.9Emphysema, unspecified

    Showing 1–10 of 26

    Related Payer Policy Updates

    Specialty: Genetic & Molecular Testing1 / 3

    10 rows

    PolicyPayerEffective Date
    Oral Cancer Screening and TestingOscar Health2027-01-01
    RTM Testing for Alpha-1 Antitrypsin DeficiencyOscar Health2027-01-01
    Cytochrome P450 Genotype-Guided Treatment Strategy Corporate Medical Policybcbsvermont2027-01-01
    Carrier Testing Panels for Genetic Diseases (for Kentucky Only)UnitedHealthcare2026-10-01
    Genetic Testing for Neurological Disorders (for Kansas Only)UnitedHealthcare2026-10-01
    Genetic and Molecular TestingProvidence Health Plan2026-10-01
    Cell-Free Fetal DNA Testing (for Idaho Only)UnitedHealthcare2026-10-01
    Next Generation Sequencing for Minimal Residual Disease DetectionProvidence Health Plan2026-10-01
    Pharmacogenetic Panel Testing (for Kansas Only)UnitedHealthcare2026-10-01
    Non-Covered Genetic Panel TestsProvidence Health Plan2026-10-01

    Related Codes

    CPT-89049-CAFFEINE-HALOTHANE-CONTRACTURE-TEST-MH-SUSCEPTIBILITY

    CPT 89049: Caffeine-Halothane Contracture Test for Malignant Hyperthermia Susceptibility

    CPT-89050-CSF-JOINT-FLUID-CELL-COUNT

    CPT 89050: Cell Count of Miscellaneous Body Fluids (CSF, Joint Fluid)

    CPT-89051-BODY-FLUID-CELL-COUNT-DIFFERENTIAL-NON-BLOOD

    CPT 89051: Body Fluid Cell Count with Differential

    CPT-89055-STOOL-LEUKOCYTE-ANALYSIS

    CPT 89055: Stool Leukocyte Test, Technical Component

    CPT-89060-MICROSCOPIC-CRYSTAL-ANALYSIS-TISSUE-BODY-FLUID

    CPT 89060: Crystal Analysis by Light Microscopy

    CPT-89125-FAT-STAIN-STOOL-URINE-RESPIRATORY-SPECIMEN

    CPT 89125: Fat Stain of Feces, Urine, or Respiratory Secretions

    CPT-89160-FECAL-MUSCLE-FIBER-MICROSCOPY

    CPT 89160: Fecal Microscopic Examination for Muscle Fibers

    CPT-89190-NASAL-SMEAR-EOSINOPHIL-ANALYSIS

    CPT 89190: Nasal Smear Examination for Eosinophils

    CPT-89230-SWEAT-COLLECTION-BY-IONTOPHORESIS

    CPT 89230: Sweat Collection by Iontophoresis

    CPT-89240-UNLISTED-PATHOLOGY-PROCEDURE

    CPT 89240: Unlisted Pathology Procedure

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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