Headline: CPT code 88275: Interphase FISH Analysis of 100–300 Cells, Clinical Diagnostic Cytogenetics

Lead: CPT code 88275 denotes a molecular cytogenetic assay using interphase in situ hybridization (FISH) in which an analyst examines 100 to 300 cells. The test identifies chromosomal abnormalities without requiring dividing cells and is used across oncology, prenatal, and genetic diagnostic workflows.

What this code represents and why it matters: CPT code 88275 captures an intermediate-intensity interphase FISH procedure that quantifies signals across a substantial cell count (100–300 cells). Nationally, this level of analysis supports diagnostic certainty for chromosome-level abnormalities, informs treatment planning in hematologic and solid-tumor settings, and underpins many hereditary and prenatal evaluations.

Key payers covered: The analysis considers major national payers including Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare.

What readers will learn: The publication explains the clinical context and laboratory service captured by CPT code 88275, typical sites of service, and the role of 100–300 cell interphase FISH in care pathways. It provides benchmarks and policy-relevant context where available, highlights payer coverage considerations, and summarizes implications for billing and documentation. Data not available in the input are noted where applicable.