CPT code 88245 represents a cytogenetic laboratory procedure: chromosome analysis for Sister Chromatid Exchange (SCE) using cultured lymphocyte cells from blood or bone marrow, evaluating 20–25 cells for chromosomal breakage characteristics. This specialized test supports diagnosis and characterization of chromosomal instability and certain genetic or exposure-related conditions. Nationally, accurate coding and coverage of cytogenetic assays like 88245 influence access to diagnostic testing and laboratory service billing consistency.

Key payers in the coverage landscape include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of clinical context for SCE testing, typical sites where the service is performed, and the payer mix most often involved with this type of laboratory billing.

This publication provides benchmarks and policy-relevant details useful for laboratory billing specialists, medical coders, and policy analysts: clinical indications and the laboratory process implied by the code, payer coverage considerations and common modifiers used with laboratory services, and practical guidance on documentation elements aligned with the procedure description. Data not available in the input is noted where applicable.