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CPT 88272: FISH Molecular Cytogenetic Test, 3–5 Cells
CPT code 88272 covers a targeted molecular cytogenetic assay using chromosomal in situ hybridization, most often fluorescence in situ hybridization (FISH), to evaluate three to five cells for chromosomal derivatives and marker chromosomes. This test is clinically important for prenatal and hematologic genetic evaluation, enabling detection of specific rearrangements and additional genetic material that influence diagnosis, prognosis, and care planning. Nationally, such assays are integral to genetic diagnostics in obstetrics and clinical pathology laboratories.
Key payers addressed in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. The publication provides an overview of coverage and reimbursement benchmarks, clinical context for when the assay is used (for example, amniotic fluid and blood specimens), and policy considerations influencing laboratory billing and documentation. Readers will find concise benchmarks of coverage practice, common site-of-service considerations, and a clear clinical description of the assay's role. Data not available in the input is noted where applicable.
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Billing Code Overview
CPT code 88272 describes a molecular cytogenetic test performed using chromosomal in situ hybridization methods, typically fluorescence in situ hybridization (FISH), to analyze three to five cells for chromosomal abnormalities such as derivatives and marker chromosomes. The procedure is commonly applied to specimens like amniotic fluid or blood to detect specific genetic rearrangements and additions of genetic material.
Service Type: Molecular cytogenetic testing (chromosomal in situ hybridization / FISH)
Typical Site of Service: Clinical laboratory or hospital laboratory