CPT code 88271 describes a molecular cytogenetic test performed by an analyst using a DNA probe method such as fluorescence in situ hybridization (FISH) to detect genetic abnormalities in cells; this service is a molecular cytogenetic diagnostic assay typically performed in a clinical laboratory or pathology laboratory setting on patient tissue or cell specimens.

For related coverage guidance, see recent payer policy updates: RTM Testing of Homocysteine Metabolism-Related Conditions, Multimarker Serum Testing Related to Ovarian Cancer, Genomic Profiling for Selecting Targeted Cancer Therapies.