CPT code 87593 describes an amplified nucleic acid probe test performed on a specimen such as a skin‑lesion swab to detect orthopoxvirus nucleic acids (DNA or RNA), a molecular diagnostic service typically performed by a clinical laboratory or hospital laboratory using amplified nucleic acid probe techniques; typical sites of service include outpatient laboratories, hospital laboratories, and other clinical diagnostic laboratory settings.

For related coverage guidance, see recent payer policy updates: B-Hemolytic Streptococcus Testing, Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance Assays, Hepatitis Testing (A, B, C, D) Coverage Criteria.