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    v1.0.30
    OpenPayerBilling CodesInfectious Agent Antigen DetectionCPT cpt-87492-chlamydia-trachomatis-nucleic-acid-probe-quantitative
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    CPT 87492: Quantitative Chlamydia trachomatis Nucleic Acid Probe Test

    CPT code 87492 describes a laboratory procedure in which a lab analyst performs a quantitative nucleic acid probe test to measure infection with Chlamydia trachomatis, a pathogen responsible for common sexually transmitted infections and certain ocular infections; the service is a quantitative molecular diagnostic test typically performed in a clinical laboratory or hospital laboratory setting on patient specimens collected for STI or ocular infection evaluation.

    For related coverage guidance, see recent payer policy updates: Truvada (Emtricitabine and Tenofovir Disoproxil Fumarate) for HIV Prevention and Treatment, HIV/AIDS Pharmacologic Prevention and Treatment, Long-Acting Injectable Antiretroviral Agents for HIV.

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    Clinical & Coding Specifications

    Clinical Context

    A sexually active adult female presents to a primary care clinic with dysuria, vaginal discharge, and pelvic pain. The clinician performs a focused sexual health history and pelvic exam, collects a cervical or vaginal swab (or first-catch urine for nucleic acid testing), and sends the specimen to the laboratory for nucleic acid probe testing to detect and quantify infection with Chlamydia trachomatis. The laboratory analyst processes the specimen using a nucleic acid probe technique and reports a quantitative result to the ordering clinician. Typical workflow steps include specimen collection at the outpatient clinic or STI clinic, specimen labeling and transport to the clinical laboratory, performance of the 87492 nucleic acid probe assay by laboratory personnel, quality control and verification, and result reporting into the electronic health record for clinical follow-up and treatment decisions. Typical site of service is an outpatient clinic, sexual health/STI clinic, or hospital outpatient laboratory. Common clinical scenarios also include screening of asymptomatic patients during routine sexual health visits, testing of symptomatic patients with cervicitis or urethritis, and testing of neonates or infants with conjunctivitis when ocular Chlamydia infection is suspected.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    87491Infectious agent detection by nucleic acid (e.g., Chlamydia trachomatis), amplified probe technique; direct probe technique, qualitative or presuming qualitative resultOften used as an alternative method for Chlamydia testing; may be ordered instead of or in addition to 87492 depending on laboratory methodology
    87591Infectious agent detection by nucleic acid (e.g., Neisseria gonorrhoeae), amplified probe technique; direct probe technique, qualitative or presuming qualitative resultFrequently ordered alongside 87492 for co-testing of gonorrhea and chlamydia from the same specimen
    36415Collection of venous blood by venipunctureMay be performed at the same visit when additional serologic testing (HIV, syphilis) is ordered with 87492
    87880Infectious agent antigen detection by immunoassay technique, multiple-step method; chlamydia trachomatisAlternative lab method for Chlamydia detection; may be used in different lab workflows
    G0003Physician certification or recertification for Medicare home health/homebound status (example not directly related)Data not available in the input.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    77Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207Q00000X
    208D00000X
    207L00000X
    163W00000X
    229N00000X
    207WX0120X
    125J00000X
    2355A2700X

    Related ICD-10-CM Codes

    25 rows

    ICD-10-CM CodeDescription
    A56.00Chlamydial infection of lower genitourinary tract, unspecified
    A56.01Chlamydial cystitis and urethritis
    A56.11Chlamydial female pelvic inflammatory disease
    A56.19Other chlamydial genitourinary infection
    A74.0Chlamydial conjunctivitis
    A74.89Other chlamydial diseases
    A74.9Chlamydial infection, unspecified
    N34.1Nonspecific urethritis
    N39.0Urinary tract infection, site not specified
    N76.0Acute vaginitis

    Showing 1–10 of 25

    Related Payer Policy Updates

    Specialty: Infectious Disease1 / 3

    10 rows

    PolicyPayerEffective Date
    Truvada (Emtricitabine and Tenofovir Disoproxil Fumarate) for HIV Prevention and Treatmentpremerabluecrossofwashington2026-10-01
    HIV/AIDS Pharmacologic Prevention and Treatmentpremerabluecrossofwashington2026-10-01
    Long-Acting Injectable Antiretroviral Agents for HIVColorado Rocky Mountain Health Plans2026-10-01
    B-Hemolytic Streptococcus TestingOscar Health2026-10-01
    Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance AssaysOscar Health2026-10-01
    Hepatitis Testing (A, B, C, D) Coverage CriteriaOscar Health2026-10-01
    Pathogen Panel TestingOscar Health2026-10-01
    Lyme Disease Testing Coverage CriteriaOscar Health2026-10-01
    Diagnostic Testing of Common Sexually Transmitted InfectionsOscar Health2026-10-01
    Testing for Vector-Borne InfectionsOscar Health2026-10-01

    Related Codes

    CPT-87260-ADENOVIRUS-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

    CPT 87260: Adenovirus Antigen Detection by Immunofluorescence

    CPT-87265-BORDETELLA-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

    CPT 87265: Bordetella Antigen Detection by Immunofluorescence

    CPT-87267-ENTEROVIRUS-DFA-ANTIGEN-DETECTION

    CPT 87267: Enterovirus Antigen Detection by DFA

    CPT-87269-GIARDIA-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

    CPT 87269: Giardia Antigen Detection by Immunofluorescence

    CPT-87270-CHLAMYDIA-TRACHOMATIS-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

    CPT 87270: Chlamydia trachomatis Antigen Detection by Immunofluorescence

    CPT-87271-CMV-DFA-ANTIGEN-DETECTION

    CPT 87271: CMV Antigen Detection by Direct Fluorescent Antibody

    CPT-87272-CRYPTOSPORIDIUM-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

    CPT 87272: Cryptosporidium Antigen Immunofluorescent Test

    CPT-87273-HSV-2-ANTIGEN-IMMUNOFLUORESCENCE

    CPT 87273: HSV-2 Antigen Detection by Immunofluorescence

    CPT-87274-HSV-1-ANTIGEN-IMMUNOFLUORESCENCE

    CPT 87274: HSV-1 Antigen Detection by Immunofluorescence

    CPT-87275-INFLUENZA-B-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

    CPT 87275: Influenza B Antigen Detection by Immunofluorescence

    Showing 1–10 of 167

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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