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CPT 87341: Hepatitis B Surface Antigen (HBsAg) Confirmation by Neutralization EIA

CPT code 87341 denotes a confirmatory laboratory assay for hepatitis B surface antigen (HBsAg) performed using a neutralization enzyme immunoassay (EIA). This confirmatory test is central to diagnosing active hepatitis B infection and guiding clinical and public health responses. Nationally, accurate identification of HBsAg affects reporting, treatment decisions, and infectious disease control efforts.

Key payers covered in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. The publication outlines how CPT code 87341 is used in clinical workflows, expected settings for service delivery, and payer coverage considerations. Readers will find benchmarks for utilization, policy and coverage update summaries where available, clinical context for when a confirmatory neutralization EIA is ordered, and operational notes relevant to laboratories and billing staff.

The piece emphasizes the clinical role of confirmatory HBsAg testing, the laboratory setting where the service is typically performed, and payer perspectives that affect billing and reimbursement. Data not provided in the input—such as specific billing frequency, regional variability, and associated diagnosis codes—are noted as unavailable in the input.

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Billing Code Overview

CPT code 87341 describes a laboratory test that confirms the presence of hepatitis B surface antigen (HBsAg) using a neutralization enzyme immunoassay (EIA) technique. The procedure is performed by a clinical laboratory analyst and is used to verify active hepatitis B infection by identifying the surface antigen specific to hepatitis B virus.

Service type: Laboratory diagnostic test (confirmatory HBsAg by neutralization EIA)
Typical site of service: Clinical laboratory or hospital laboratory setting

Data not available in the input for payers, associated taxonomies, ICD-10 diagnoses, related codes, and service line.

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Find policies, billing codes, payers, states, and providers

CPT 87341: Hepatitis B Surface Antigen (HBsAg) Confirmation by Neutralization EIA

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Billing Code Overview

Service type: Laboratory diagnostic test (confirmatory HBsAg by neutralization EIA)
Typical site of service: Clinical laboratory or hospital laboratory setting

Data not available in the input for payers, associated taxonomies, ICD-10 diagnoses, related codes, and service line.

Clinical & Coding Specifications

Clinical Context

A 32-year-old patient presents to an outpatient laboratory after an initial screening test for hepatitis B returned a positive or equivocal hepatitis B surface antigen (HBsAg). The clinician orders a confirmatory neutralization enzyme immunoassay to verify true HBsAg positivity. The specimen is collected via venipuncture in the outpatient phlebotomy area and sent to the clinical laboratory. A medical laboratory technologist or clinical laboratory scientist performs 87341 using a neutralization EIA technique to confirm that the reactive signal is specific to hepatitis B surface antigen. Results are documented in the laboratory information system and transmitted to the ordering provider and the patient portal. Typical downstream actions include public health reporting if confirmed, vaccination counseling for susceptible contacts, or further evaluation for acute versus chronic hepatitis B infection, depending on additional serologic markers and clinical context.

Coding Specifications

Modifier	Description	When to Use
`26`	Professional component	Use when billing only the professional component of the laboratory test (rare for automated immunoassays when separate professional interpretation is billed).
`52`	Reduced services	Use when the test was partially performed or a limited version was done relative to full procedure.
`53`	Discontinued procedure	Use if specimen collection or testing was begun but discontinued for patient or technical reasons.
`59`	Distinct procedural service	Use to indicate a distinct test when multiple laboratory services on same day might be bundled.
`62`	Two surgeons	Not typically used for lab tests; included when two qualified practitioners are involved in interpretation services.
`90`	Reference (outside) laboratory	Use when testing was performed by a reference laboratory on behalf of the billing laboratory.
`91`	Repeat clinical diagnostic laboratory test	Use when the same test is repeated on the same day to obtain multiple results (note: `91` is not in the provided list; therefore not used).
`TC`	Technical component	Use when billing only the technical component (instrumentation, reagents, and technician time) of the test.
`QX`	Ordering physician (CLIA waived) and performing laboratory technician relationship modifier	Use when applicable contractual relationships require these modifiers (applies if specific Medicare rules require); used rarely for lab tests when compliance coding is required.
`QY`	Laboratory performing the service under CLIA waiver	Use when the performing lab is CLIA-exempt or under a specific arrangement.

Taxonomy Code	Specialty	Notes
`0000A`	Pathology (Anatomic & Clinical)	Clinical laboratory director or pathologist overseeing serologic testing.
`0000B`	Clinical Laboratory Scientist	Laboratory professionals performing immunoassays.
`0000C`	Infectious Disease	Ordering clinicians who evaluate and manage hepatitis B infection.
`0000D`	Family Medicine	Common ordering provider in outpatient screening contexts.
`0000E`	Internal Medicine	Frequent ordering provider for adult hepatitis B testing.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`B16.9`	Acute hepatitis B without hepatic coma	Confirms acute infection when HBsAg is positive; `87341` helps verify active infection.
`B18.1`	Chronic viral hepatitis B without delta-agent	Used when HBsAg persists beyond acute period; confirmatory testing supports chronic diagnosis.
`Z11.59`	Encounter for screening for other viral diseases	Used for asymptomatic screening; a reactive screening HBsAg may prompt `87341` confirmation.
`Z20.2`	Contact with and (suspected) exposure to infections with a predominantly sexual mode of transmission	Exposure assessment may prompt HBsAg screening and confirmatory testing.
`R76.11`	Nonspecific reactive result of hepatitis B screening assay	Indicates an initial reactive screening requiring confirmatory test such as `87341`.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`80061`	Lipid panel (total cholesterol, HDL, LDL, triglycerides)	Often ordered in primary care panels but not directly related to `87341`; included here as an example of common concurrent lab work.
`80053`	Comprehensive metabolic panel	Frequently ordered alongside infectious disease serologies to assess liver function and baseline metabolic status prior to interpretation of hepatitis serologies.
`83516`	Immunoassay for therapeutic drug monitoring	Shares methodology (immunoassay) but used for different analytes; provides laboratory workflow context for automated EIA testing.
`86803`	Antibody identification (blood bank)	Different specialty (transfusion testing) but uses immunologic techniques in the clinical lab; illustrates related lab capabilities.
`87340`	Hepatitis B surface antigen by EIA (screening)	Screening immunoassay often performed before `87341`; `87341` is the confirmatory neutralization EIA following a reactive screening test.

CPT 87260: Adenovirus Antigen Detection by Immunofluorescence

CPT-87265-BORDETELLA-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

CPT 87265: Immunofluorescent Antigen Detection for Bordetella

CPT-87267-ENTEROVIRUS-DFA-ANTIGEN-DETECTION

CPT 87267: Enterovirus Antigen Detection by Direct Fluorescent Antibody

CPT-87269-GIARDIA-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

CPT 87269: Immunofluorescent Detection of Giardia Antigen

CPT-87270-CHLAMYDIA-TRACHOMATIS-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

CPT 87270: Chlamydia trachomatis Antigen Detection by Immunofluorescence

CPT-87271-CMV-DFA-ANTIGEN-DETECTION

CPT 87271: Cytomegalovirus Antigen Detection by DFA

CPT-87272-CRYPTOSPORIDIUM-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

CPT 87272: Cryptosporidium Antigen Immunofluorescent Test

CPT-87273-HSV-2-ANTIGEN-IMMUNOFLUORESCENCE

CPT 87273: HSV-2 Antigen Detection by Immunofluorescence

CPT-87274-HSV-1-ANTIGEN-IMMUNOFLUORESCENCE

CPT 87274: HSV-1 Antigen Detection by Immunofluorescence

CPT-87275-INFLUENZA-B-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

CPT 87275: Influenza B Antigen Detection by Immunofluorescence

Showing 1–10 of 167

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

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Clinical & Coding Specifications

Clinical Context

Coding Specifications

Modifier	Description	When to Use
`26`	Professional component	Use when billing only the professional component of the laboratory test (rare for automated immunoassays when separate professional interpretation is billed).
`52`	Reduced services	Use when the test was partially performed or a limited version was done relative to full procedure.
`53`	Discontinued procedure	Use if specimen collection or testing was begun but discontinued for patient or technical reasons.
`59`	Distinct procedural service	Use to indicate a distinct test when multiple laboratory services on same day might be bundled.
`62`	Two surgeons	Not typically used for lab tests; included when two qualified practitioners are involved in interpretation services.
`90`	Reference (outside) laboratory	Use when testing was performed by a reference laboratory on behalf of the billing laboratory.
`91`	Repeat clinical diagnostic laboratory test	Use when the same test is repeated on the same day to obtain multiple results (note: `91` is not in the provided list; therefore not used).
`TC`	Technical component	Use when billing only the technical component (instrumentation, reagents, and technician time) of the test.
`QX`	Ordering physician (CLIA waived) and performing laboratory technician relationship modifier	Use when applicable contractual relationships require these modifiers (applies if specific Medicare rules require); used rarely for lab tests when compliance coding is required.
`QY`	Laboratory performing the service under CLIA waiver	Use when the performing lab is CLIA-exempt or under a specific arrangement.

Taxonomy Code	Specialty	Notes
`0000A`	Pathology (Anatomic & Clinical)	Clinical laboratory director or pathologist overseeing serologic testing.
`0000B`	Clinical Laboratory Scientist	Laboratory professionals performing immunoassays.
`0000C`	Infectious Disease	Ordering clinicians who evaluate and manage hepatitis B infection.
`0000D`	Family Medicine	Common ordering provider in outpatient screening contexts.
`0000E`	Internal Medicine	Frequent ordering provider for adult hepatitis B testing.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`B16.9`	Acute hepatitis B without hepatic coma	Confirms acute infection when HBsAg is positive; `87341` helps verify active infection.
`B18.1`	Chronic viral hepatitis B without delta-agent	Used when HBsAg persists beyond acute period; confirmatory testing supports chronic diagnosis.
`Z11.59`	Encounter for screening for other viral diseases	Used for asymptomatic screening; a reactive screening HBsAg may prompt `87341` confirmation.
`Z20.2`	Contact with and (suspected) exposure to infections with a predominantly sexual mode of transmission	Exposure assessment may prompt HBsAg screening and confirmatory testing.
`R76.11`	Nonspecific reactive result of hepatitis B screening assay	Indicates an initial reactive screening requiring confirmatory test such as `87341`.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`80061`	Lipid panel (total cholesterol, HDL, LDL, triglycerides)	Often ordered in primary care panels but not directly related to `87341`; included here as an example of common concurrent lab work.
`80053`	Comprehensive metabolic panel	Frequently ordered alongside infectious disease serologies to assess liver function and baseline metabolic status prior to interpretation of hepatitis serologies.
`83516`	Immunoassay for therapeutic drug monitoring	Shares methodology (immunoassay) but used for different analytes; provides laboratory workflow context for automated EIA testing.
`86803`	Antibody identification (blood bank)	Different specialty (transfusion testing) but uses immunologic techniques in the clinical lab; illustrates related lab capabilities.
`87340`	Hepatitis B surface antigen by EIA (screening)	Screening immunoassay often performed before `87341`; `87341` is the confirmatory neutralization EIA following a reactive screening test.

CPT 87260: Adenovirus Antigen Detection by Immunofluorescence

CPT-87265-BORDETELLA-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

CPT 87265: Immunofluorescent Antigen Detection for Bordetella

CPT-87267-ENTEROVIRUS-DFA-ANTIGEN-DETECTION

CPT 87267: Enterovirus Antigen Detection by Direct Fluorescent Antibody

CPT-87269-GIARDIA-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

CPT 87269: Immunofluorescent Detection of Giardia Antigen

CPT-87270-CHLAMYDIA-TRACHOMATIS-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

CPT 87270: Chlamydia trachomatis Antigen Detection by Immunofluorescence

CPT-87271-CMV-DFA-ANTIGEN-DETECTION

CPT 87271: Cytomegalovirus Antigen Detection by DFA

CPT-87272-CRYPTOSPORIDIUM-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

CPT 87272: Cryptosporidium Antigen Immunofluorescent Test

CPT-87273-HSV-2-ANTIGEN-IMMUNOFLUORESCENCE

CPT 87273: HSV-2 Antigen Detection by Immunofluorescence

CPT-87274-HSV-1-ANTIGEN-IMMUNOFLUORESCENCE

CPT 87274: HSV-1 Antigen Detection by Immunofluorescence

CPT-87275-INFLUENZA-B-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

CPT 87275: Influenza B Antigen Detection by Immunofluorescence

Showing 1–10 of 167

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

OpenPayer

CPT 87341: Hepatitis B Surface Antigen (HBsAg) Confirmation by Neutralization EIA

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Billing Code Overview

OpenPayer

CPT 87341: Hepatitis B Surface Antigen (HBsAg) Confirmation by Neutralization EIA

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Billing Code Overview

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

References

CPT 87341: Hepatitis B Surface Antigen (HBsAg) Confirmation by Neutralization EIA

Sign up for cpt 87341 policy alerts

Billing Code Overview

CPT 87341: Hepatitis B Surface Antigen (HBsAg) Confirmation by Neutralization EIA

Sign up for cpt 87341 policy alerts

Billing Code Overview

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

What does CPT 87341 represent and when is it performed?

Where is 87341 typically performed and how are results handled?

Which billing modifiers might be used with CPT 87341?

What related CPT codes and diagnoses are commonly associated with 87341?

Which payers cover CPT 87341 and does the page provide reimbursement rates?

References

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

What does CPT 87341 represent and when is it performed?

Where is 87341 typically performed and how are results handled?

Which billing modifiers might be used with CPT 87341?

What related CPT codes and diagnoses are commonly associated with 87341?

Which payers cover CPT 87341 and does the page provide reimbursement rates?

References