CPT code 87338 represents a stool antigen immunoassay for detection of Helicobacter pylori, a noninvasive diagnostic laboratory test used to identify H. pylori infection. Nationally, this assay is an important tool in diagnosing H. pylori–related gastritis and peptic ulcer disease, guiding treatment decisions and test-of-cure strategies. The code captures laboratory work performed on stool specimens using immunoassay methods such as enzyme immunoassay (EIA).

Key payers covered in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise clinical context for the test, the typical sites where the service is delivered, and the billing context for laboratory administrators and coders. The publication also outlines common modifiers and related billing considerations where available.

This summary provides actionable reference material for stakeholders who manage laboratory billing, utilization review, and clinical decision support. It highlights the clinical role of the stool antigen test for H. pylori, notes typical laboratory settings, and flags where input data was not provided. Readers will gain clear, nationally relevant context to support coding and administrative workflows for CPT code 87338.