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    v1.0.28
    OpenPayerBilling CodesTransfusion Medicine ProceduresCPT cpt-86923-electronic-crossmatch-blood-compatibility
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    CPT 86923: Donor-Patient Compatibility Crossmatch via LIS

    CPT code 86923 describes a laboratory compatibility evaluation (crossmatch) in which the lab analyst compares patient and donor type-and-screen records electronically via the Laboratory Information System; service type is a laboratory blood compatibility test and the typical site of service is the hospital or reference laboratory clinical laboratory performing transfusion compatibility testing.

    For related coverage guidance, see recent payer policy updates: Epithelial Cell Cytology in Breast Cancer Risk Assessment, Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only), Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only).

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult hospitalized for acute anemia secondary to gastrointestinal bleeding who may require packed red blood cell (PRBC) transfusion. Prior to transfusion, the transfusion service performs a compatibility check (crossmatch) using the laboratory information system to compare the patient’s type and screen with the donor unit records. The workflow: order entry by the primary team for blood transfusion → collection of EDTA specimen for type and screen if not already on file → blood bank technologist reviews patient ABO/Rh and antibody screen results in the LIS → selects candidate donor unit(s) and performs electronic compatibility check and record comparison → documents the evaluation and releases compatible unit for transfusion. Typical site of service is the hospital blood bank/laboratory; service type is clinical laboratory compatibility evaluation (electronic crossmatch). The patient scenario commonly involves preoperative patients, obstetric patients with hemorrhage, trauma patients, or medical patients with symptomatic anemia where an electronic crossmatch is indicated and no clinically significant antibodies are present.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    86922Compatibility test, recipient and donor serum — basic serologic crossmatch (manual)Represents the traditional serologic crossmatch that may be performed when electronic crossmatch is not appropriate (e.g., when clinically significant antibodies are present).
    86850Blood typing; ABO and Rh(D)Performed prior to or as part of the type and screen that informs the electronic compatibility check.
    86860Antibody screen; major (indirect antiglobulin test)Detects clinically significant alloantibodies that would contraindicate an electronic crossmatch and necessitate further serologic testing.
    86901Immunohematology tests, multiple reagent red cell panelUsed when antibody identification is required after a positive antibody screen and before donor selection.
    99000Handling and/or conveyance of specimen (if applicable)Sometimes billed by institutions for specimen processing related to transfusion services (payor policies vary).

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207RH0000XHematology (Internal Medicine) PhysicianAn internist with additional training who specializes in diseases of the blood, spleen and lymph. This specialist treats conditions such as anemia, cl…
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    207LP2900XPain Medicine (Anesthesiology) PhysicianAn anesthesiologist who provides a high level of care, either as a primary physician or consultant, for patients experiencing problems with acute, chr…
    207K00000XAllergy & Immunology PhysicianAn allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
    111NI0013XIndependent Medical Examiner ChiropractorA special evaluator not involved with the medical care of the individual examinee that impartially evaluates the care being provided by other practiti…
    193200000XMulti-Specialty GroupA business group of one or more individual practitioners, who practice with different areas of specialization.
    364SX0204XPediatric Oncology Clinical Nurse SpecialistPhysician Assistants & Advanced Practice Nursing Providers · Clinical Nurse Specialist
    207RS0010XSports Medicine (Internal Medicine) PhysicianAn internist trained to be responsible for continuous care in the field of sports medicine, not only for the enhancement of health and fitness, but al…

    Related ICD-10-CM Codes

    27 rows

    ICD-10-CM CodeDescription
    C34.90Malignant neoplasm of unspecified part of unspecified bronchus or lung
    C50.911Malignant neoplasm of unspecified site of right female breast
    D46.9Myelodysplastic syndrome, unspecified
    D50.9Iron deficiency anemia, unspecified
    D56.9Thalassemia, unspecified
    D62Acute posthemorrhagic anemia
    D63.1Anemia in chronic kidney disease
    D65Disseminated intravascular coagulation [defibrination syndrome]
    D66Hereditary factor VIII deficiency
    D67Hereditary factor IX deficiency

    Showing 1–10 of 27

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    10 rows

    PolicyPayerEffective Date
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only)UnitedHealthcare2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only)UnitedHealthcare2026-08-01
    Antibody-Drug ConjugatesPremera Bluecross2026-08-01
    Chimeric Antigen Receptor (CAR) T-Cell TherapyColorado Rocky Mountain Health Plans2026-08-01
    Allogeneic Hematopoietic Progenitor Cell TherapyAmbetter Georgia2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Idaho Only)UnitedHealthcare2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for New Jersey Only)UnitedHealthcare2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Ohio Only)UnitedHealthcare2026-08-01
    Reblozyl (luspatercept-aamt) Medical Benefit Drug PolicyUnitedHealthcare2026-08-01

    Related Codes

    CPT-86850-RBC-ANTIBODY-SCREENING

    CPT 86850: Screening Test for Non‑A/B Red Blood Cell Antibodies

    CPT-86860-RBC-ELUTION-IMMUNOHEMATOLOGY-BLOOD-BANK

    CPT 86860: RBC Elution for Antibody Detection

    CPT-86870-RBC-ANTIBODY-IDENTIFICATION-IMMUNOHEMATOLOGY

    CPT 86870: Antibody Identification to Red Blood Cells

    CPT-86880-DIRECT-ANTIGLOBULIN-TEST-DAT-COOMBS

    CPT 86880: Direct Antihuman Globulin (Coombs) Test

    CPT-86885-INDIRECT-ANTIGLOBULIN-COOMBS-TEST

    CPT 86885: Indirect Antiglobulin (Coombs) Test for Serum Antibodies

    CPT-86886-INDIRECT-ANTIGLOBULIN-COOMBS-TEST-SERIAL-DILUTIONS

    CPT 86886: Indirect Antihuman Globulin (Coombs) Test

    CPT-86890-AUTOLOGOUS-BLOOD-COLLECTION-PROCESSING-STORAGE

    CPT 86890: Autologous Blood Collection, Processing, and Storage

    CPT-86891-INTRAOPERATIVE-BLOOD-SALVAGE-AUTOTRANSFUSION

    CPT 86891: Intraoperative Blood Salvage (Cell Salvage)

    CPT-86900-ABO-BLOOD-TYPING-SERUM-PLASMA

    CPT 86900: ABO Blood Typing Using Serum or Plasma

    CPT-86901-RH-BLOOD-GROUP-TYPING-SEROLOGIC-PLASMA-SERUM

    CPT 86901: Rh Blood Group Serologic Typing, Serum/Plasma

    Showing 1–10 of 38

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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