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    v1.0.28
    OpenPayerBilling CodesTransfusion Medicine ProceduresCPT cpt-86922-pretransfusion-crossmatch-antiglobulin-technique
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    CPT 86922: Antiglobulin Crossmatch for Donor-Recipient Compatibility

    CPT code 86922 describes an antiglobulin crossmatch performed by a laboratory analyst to assess compatibility between a donor blood unit and a patient’s serum using an antiglobulin technique; the service is a blood bank compatibility test typically performed in a hospital laboratory or transfusion service prior to transfusion to detect clinically significant antibodies and help ensure safe blood component selection.

    For related coverage guidance, see recent payer policy updates: Epithelial Cell Cytology in Breast Cancer Risk Assessment, Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only), Antibody-Drug Conjugates.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient scenario involves a hospitalized adult who requires transfusion of packed red blood cells for anemia or acute blood loss. A pretransfusion compatibility test (antiglobulin crossmatch) is ordered by the clinical team when a compatible donor unit is needed. The blood bank receives a current patient serum sample and the selected donor unit sample. A laboratory technologist performs antibody screening and an antiglobulin (indirect Coombs) crossmatch to detect clinically significant alloantibodies and confirm compatibility prior to issuing the unit. Results are documented in the blood bank record, and a compatible unit is released to the nursing staff for transfusion. Common clinical workflows include emergent type-and-screen with immediate spin for urgent transfusion followed by an antiglobulin crossmatch when time allows, routine preoperative crossmatch for scheduled surgery, or repeat crossmatching when the patient has had recent transfusions, pregnancy, or positive antibody screens.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    86922Antiglobulin (AHG) crossmatch testPrimary crossmatch test to confirm donor red blood cell compatibility with patient serum.
    86900Blood compatibility test; major and minor crossmatchingAlternative crossmatch code used in some workflows; may be used for different methods or combined services.
    86901Blood grouping and antibody screen (includes Rh typing)Performed before or alongside crossmatch to determine ABO/Rh and detect antibodies that affect crossmatch.
    86592Antibody identification procedureUsed when a positive antibody screen requires panel testing to identify specific alloantibodies that impact compatibility and crossmatching.
    36430Transfusion; infusion of blood or blood componentsThe clinical transfusion event that follows a compatible crossmatch and release of blood products.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207Q00000XFamily Medicine PhysicianFamily Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
    207RA0000XAdolescent Medicine (Internal Medicine) PhysicianAn internist who specializes in adolescent medicine is a multi-disciplinary healthcare specialist trained in the unique physical, psychological and so…
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    227800000XCertified Respiratory TherapistA Certified Respiratory Therapist (CRT) is a an entry level therapist who has passed a standardized written examination administered by the National B…
    335G00000XMedical Foods SupplierA supplier of special replacement foods for clients with errors of metabolism that prohibit them from eating a regular diet. Medical foods are lacki…
    282NW0100XWomen's HospitalHospitals · General Acute Care Hospital
    331L00000XBlood BankAn institution (organization or distinct part thereof) that performs, or is responsible for the performance of, the collection, processing, storage an…
    225XE1200XErgonomics Occupational TherapistRespiratory, Developmental, Rehabilitative and Restorative Service Providers · Occupational Therapist

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    4 rows

    PolicyPayerEffective Date
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only)UnitedHealthcare2026-08-01
    Antibody-Drug ConjugatesPremera Bluecross2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only)UnitedHealthcare2026-08-01

    Related Codes

    CPT-86850-RBC-ANTIBODY-SCREENING

    CPT 86850: Screening Test for Non‑A/B Red Blood Cell Antibodies

    CPT-86860-RBC-ELUTION-IMMUNOHEMATOLOGY-BLOOD-BANK

    CPT 86860: RBC Elution for Antibody Detection

    CPT-86870-RBC-ANTIBODY-IDENTIFICATION-IMMUNOHEMATOLOGY

    CPT 86870: Antibody Identification to Red Blood Cells

    CPT-86880-DIRECT-ANTIGLOBULIN-TEST-DAT-COOMBS

    CPT 86880: Direct Antihuman Globulin (Coombs) Test

    CPT-86885-INDIRECT-ANTIGLOBULIN-COOMBS-TEST

    CPT 86885: Indirect Antiglobulin (Coombs) Test for Serum Antibodies

    CPT-86886-INDIRECT-ANTIGLOBULIN-COOMBS-TEST-SERIAL-DILUTIONS

    CPT 86886: Indirect Antihuman Globulin (Coombs) Test

    CPT-86890-AUTOLOGOUS-BLOOD-COLLECTION-PROCESSING-STORAGE

    CPT 86890: Autologous Blood Collection, Processing, and Storage

    CPT-86891-INTRAOPERATIVE-BLOOD-SALVAGE-AUTOTRANSFUSION

    CPT 86891: Intraoperative Blood Salvage (Cell Salvage)

    CPT-86900-ABO-BLOOD-TYPING-SERUM-PLASMA

    CPT 86900: ABO Blood Typing Using Serum or Plasma

    CPT-86901-RH-BLOOD-GROUP-TYPING-SEROLOGIC-PLASMA-SERUM

    CPT 86901: Rh Blood Group Serologic Typing, Serum/Plasma

    Showing 1–10 of 38

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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