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    v1.0.30
    OpenPayerBilling CodesTransfusion Medicine ProceduresCPT cpt-86880-direct-antiglobulin-test-dat-coombs
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    CPT 86880: Direct Antihuman Globulin (Coombs) Test

    CPT code 86880 describes a direct antiglobulin (antihuman globulin) test, commonly called a direct Coombs test or DAT, performed by a laboratory analyst to detect antibodies or complement bound to a patient’s red blood cells; this is a clinical laboratory immunohematology service typically performed in a hospital clinical laboratory, outpatient laboratory, or blood bank setting to evaluate hemolytic anemia, transfusion reactions, or immune-mediated red cell destruction.

    For related coverage guidance, see recent payer policy updates: Hematology - Adzynma, Tumor Treating Fields for Pancreatic Cancer, Axicabtagene ciloleucel (Yescarta®) coverage.

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    Clinical & Coding Specifications

    Clinical Context

    A 32-year-old pregnant woman presents to the obstetric clinic with a prior history of blood transfusion and a positive antibody screen. Her prenatal laboratory panel demonstrates unexplained anemia and a positive indirect antiglobulin test (IAT). The obstetrician orders a direct antiglobulin test (86880) on the patient’s red blood cells to determine whether maternal or autoantibodies are coating the patient’s erythrocytes, which could indicate immune hemolysis or alloimmunization relevant to fetal risk.

    Specimen collection occurs in the outpatient clinic or hospital phlebotomy area; a whole blood tube is sent to the clinical immunohematology laboratory. The lab technologist performs 86880 (direct antiglobulin test/DAT) using polyspecific and monospecific anti-IgG and anti-complement reagents. Results are reported to the ordering clinician and documented in the medical record. Typical sites of service include outpatient laboratories, hospital clinical laboratories, transfusion services, and inpatient hospital wards when hemolysis is suspected.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    80053Comprehensive metabolic panelOrdered concurrently to assess hemolysis effects (bilirubin, LDH, creatinine)
    85025Blood count; automated differential WBC countUsed to evaluate anemia severity and reticulocyte response alongside DAT
    87040Culture, bacterial; blood, aerobic and anaerobic bottlePerformed if concern for sepsis contributing to hemolysis in inpatient settings
    86900Antibody identification; serumFollow-up when DAT positive to identify specific allo- or autoantibodies responsible for RBC coating
    87880Antibody detection (indirect antiglobulin test)Indirect antiglobulin test (IAT) complements DAT for antibody screening and compatibility testing

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207Q00000X
    207K00000X
    207L00000X
    208000000X
    246X00000X
    320900000X
    225XF0002X
    261QM0850X

    Related ICD-10-CM Codes

    19 rows

    ICD-10-CM CodeDescription
    D50.9Iron deficiency anemia, unspecified
    D56.1Beta thalassemia
    D57.1Sickle-cell disease without crisis
    D57.819Other sickle-cell disorders with crisis, unspecified
    D59.0Drug-induced autoimmune hemolytic anemia
    D59.2Drug-induced nonautoimmune hemolytic anemia
    D59.8Other acquired hemolytic anemias
    D59.9Acquired hemolytic anemia, unspecified
    D62Acute posthemorrhagic anemia
    D64.9Anemia, unspecified

    Showing 1–10 of 19

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    10 rows

    PolicyPayerEffective Date
    Hematology - AdzynmaCigna2026-10-15
    Tumor Treating Fields for Pancreatic Cancerselect_health2026-10-01
    Axicabtagene ciloleucel (Yescarta®) coverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Kentucky Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Kansas Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Idaho Only)UnitedHealthcare2026-10-01
    Brexucabtagene autoleucel (Tecartus) CoverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Pennsylvania Only)UnitedHealthcare2026-10-01
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Factor VIII ProductsCigna2026-09-15

    Related Codes

    CPT-86850-RBC-ANTIBODY-SCREENING

    CPT 86850: Screening Test for Non‑A/B Red Blood Cell Antibodies

    CPT-86860-RBC-ELUTION-IMMUNOHEMATOLOGY-BLOOD-BANK

    CPT 86860: RBC Elution for Antibody Detection

    CPT-86870-RBC-ANTIBODY-IDENTIFICATION-IMMUNOHEMATOLOGY

    CPT 86870: Antibody Identification to Red Blood Cells

    CPT-86885-INDIRECT-ANTIGLOBULIN-COOMBS-TEST

    CPT 86885: Indirect Antiglobulin (Coombs) Test for Serum Antibodies

    CPT-86886-INDIRECT-ANTIGLOBULIN-COOMBS-TEST-SERIAL-DILUTIONS

    CPT 86886: Indirect Antihuman Globulin (Coombs) Test

    CPT-86890-AUTOLOGOUS-BLOOD-COLLECTION-PROCESSING-STORAGE

    CPT 86890: Autologous Blood Collection, Processing, and Storage

    CPT-86891-INTRAOPERATIVE-BLOOD-SALVAGE-AUTOTRANSFUSION

    CPT 86891: Intraoperative Blood Salvage (Cell Salvage)

    CPT-86900-ABO-BLOOD-TYPING-SERUM-PLASMA

    CPT 86900: ABO Blood Typing Using Serum or Plasma

    CPT-86901-RH-BLOOD-GROUP-TYPING-SEROLOGIC-PLASMA-SERUM

    CPT 86901: Rh Blood Group Serologic Typing, Serum/Plasma

    CPT-86902-ANTIGEN-SCREENING-DONOR-BLOOD-UNIT

    CPT 86902: Antigen Screen of Donor Blood Unit

    Showing 1–10 of 38

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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