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CPT 86880: Direct Antiglobulin (Coombs) Test for RBC-Bound Antibodies
CPT code 86880 represents the direct antiglobulin (Coombs) test, a laboratory immunohematology assay that identifies antibodies or complement bound to patient red blood cells. This test is nationally significant for diagnosing immune-mediated hemolysis, guiding transfusion decisions, and informing neonatal and hematology care. Hospitals, inpatient services, and outpatient clinical laboratories routinely order this assay in emergency, inpatient, and ambulatory settings.
Key payers considered in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of clinical context, common sites of service, and the role of 86880 in diagnostic workflows. The publication also summarizes commonly observed billing modifiers and payment considerations where available. Practical takeaways include benchmarked utilization patterns, payer coverage notes where provided, and policy or coding clarifications that affect billing and clinical documentation. Data not available in the input is noted explicitly where applicable.
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Billing Code Overview
CPT code 86880 describes a direct antiglobulin test (DAT), commonly called a direct Coombs test, performed by a laboratory analyst to determine whether antibodies are bound to the surface of a patient’s red blood cells (RBCs). The procedure detects immune-mediated hemolysis and helps guide diagnosis of conditions such as autoimmune hemolytic anemia, hemolytic transfusion reactions, and certain hemolytic disease of the newborn scenarios.
Service type: Laboratory diagnostic immunohematology test
Typical site of service: Clinical laboratory or hospital laboratory