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    v1.0.28
    OpenPayerBilling CodesQualitative or Semiquantitative ImmunoassaysCPT cpt-86663-ebv-early-antigen-ea-antibody-immunoassay
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    CPT 86663: EBV Early Antigen (EA) Antibody Immunoassay

    CPT code 86663 describes an immunoassay performed by a laboratory analyst to detect antibodies to the Epstein–Barr virus early antigen (EA) in patient serum; this is a serologic diagnostic test used to evaluate recent or reactivated EBV infection and is typically provided as a laboratory immunology service in clinical laboratory or hospital lab settings.

    For related coverage guidance, see recent payer policy updates: Diagnosis of Idiopathic Environmental Intolerance, Allergen Testing, Allergen Testing.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 19-year-old college student presents to an outpatient clinic with 2 weeks of fever, sore throat, generalized fatigue, and posterior cervical lymphadenopathy. The primary clinician suspects infectious mononucleosis and orders serologic testing for Epstein–Barr virus (EBV). A serum sample is collected via venipuncture and sent to the clinical laboratory. The laboratory performs an immunoassay to detect IgM and/or IgG antibodies directed against the EBV early antigen (EA) using CPT 86663. Results reporting includes the quantitative or qualitative EA antibody result, interpretation (consistent with acute, recent, or past infection), and a technician or lab analyst signature when required.

    Typical site of service: outpatient phlebotomy/ambulatory clinic or independent laboratory (clinical laboratory testing). Typical clinical workflow: clinician orders EBV serology → specimen collection and labeling → specimen transported to the laboratory → laboratory accessioning and performing immunoassay (CPT 86663) → result validation and reporting to ordering provider; reflex testing (e.g., heterophile antibody test, EBV viral capsid antigen IgM/IgG, EBV nuclear antigen IgG) may follow based on results.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    86762Heterophile antibodies (Monospot)Common initial point-of-care or laboratory screen for infectious mononucleosis; may be ordered before or alongside CPT 86663
    86664EBV viral capsid antigen (VCA) IgM and IgG immunoassayComplementary EBV serology used with EA antibody testing to distinguish acute versus past infection
    86789Viral antibody, not otherwise classified (e.g., EBV nuclear antigen IgG)Used for additional EBV-specific antibody testing such as EBV nuclear antigen to assess past infection
    36415Collection of venous blood by venipunctureSpecimen collection CPT commonly performed prior to laboratory testing like CPT 86663
    80053Comprehensive metabolic panelFrequently ordered concurrently to evaluate general health and organ function during acute illness

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    95Modifier 95 indicates that a service was provided via synchronous, real‑time audio‑video telehealth rather than in‑person. Per CMS, AAPC and professional associations, append modifier 95 to claim…- Use modifier 95 to indicate a service was furnished via synchronous, real‑time audiovisual telehealth (a live audio‑video conference between patient and provider) rather than in‑person. - Pair…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207Q00000XFamily Medicine PhysicianFamily Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
    207LP2900XPain Medicine (Anesthesiology) PhysicianAn anesthesiologist who provides a high level of care, either as a primary physician or consultant, for patients experiencing problems with acute, chr…
    208D00000XGeneral Practice PhysicianA physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    3336L0003XLong Term Care PharmacyA pharmacy that dispenses medicinal preparations delivered to patients residing within an intermediate or skilled nursing facility, including intermed…
    163WD0400XDiabetes Educator Registered NurseNursing Service Providers · Registered Nurse
    163WC0200XCritical Care Medicine Registered NurseNursing Service Providers · Registered Nurse
    2088F0040XUrogynecology and Reconstructive Pelvic Surgery (Urology) PhysicianA subspecialist in Urogynecology and Reconstructive Pelvic Surgery is a physician in Urology or Obstetrics and Gynecology who, by virtue of education …

    Related ICD-10-CM Codes

    22 rows

    ICD-10-CM CodeDescription
    B34.9Viral infection, unspecified
    B95.8Unspecified staphylococcus as the cause of diseases classified elsewhere
    D69.3Immune thrombocytopenic purpura
    F41.9Anxiety disorder, unspecified
    G44.1Vascular headache, not elsewhere classified
    J02.9Acute pharyngitis, unspecified
    J06.9Acute upper respiratory infection, unspecified
    K52.9Noninfective gastroenteritis and colitis, unspecified
    N39.0Urinary tract infection, site not specified
    R07.9Chest pain, unspecified

    Showing 1–10 of 22

    Related Payer Policy Updates

    Specialty: Allergy/Clinical Immunology1 / 3

    9 rows

    PolicyPayerEffective Date
    Diagnosis of Idiopathic Environmental IntoleranceOscar Health2026-10-01
    Allergen Testingblue cross blue shield - louisiana2026-09-15
    Allergen TestingBlue Cross Blue Shield - New Mexico2026-09-04
    Hereditary Angioedema - EkterlyCigna2026-08-15
    Omalizumab products (Xolair, Omlyclo) coveragePremera Bluecross2026-08-01
    Omalizumab Products (Xolair, Omlyclo) coveragePremera Bluecross2026-08-01
    Omalizumab ProductsPremera Bluecross2026-08-01
    Allergy Testinguniverahealthcare2026-07-16
    Omalizumab (Xolair) and related biologics coverageMass General Brigham Health Plan2026-07-01

    Related Codes

    86803-QUALITATIVE-OR-SEMIQUANTITATIVE-IMMUNOASSAYS-HEPATITIS-C

    CPT 86803: Hepatitis C Antibody Immunoassay in Serum

    CPT-86000-FEBRILE-AGGLUTININS-SEROLOGIC-TEST

    CPT 86000: Febrile Agglutinins (Serologic Agglutination) Test

    CPT-86001-ALLERGEN-SPECIFIC-IGG-LABORATORY-TEST

    CPT 86001: Allergen-Specific IgG Assay, Technical Component

    CPT-86003-ALLERGEN-SPECIFIC-IGE-ASSAY-TECHNICAL

    CPT 86003: Allergen‑Specific IgE Assay Using Crude Allergen Extract

    CPT-86005-MULTI-ALLERGEN-IGE-SCREENING-QUALITATIVE

    CPT 86005: Multi-Allergen Allergen-Specific IgE Screening

    CPT-86008-ALLERGEN-COMPONENT-SPECIFIC-IGE-ASSAY

    CPT 86008: Allergen Component–Specific IgE Assay

    CPT-86015-ANTI-ACTIN-SMOOTH-MUSCLE-ANTIBODY-ASMA

    CPT 86015: Actin (Smooth Muscle) Antibody (ASMA) Immunoassay

    CPT-86021-LEUKOCYTE-ANTIBODY-IDENTIFICATION-LAB-TECHNICAL

    CPT 86021: Leukocyte Antibody Identification Laboratory Test

    CPT-86022-PLATELET-ANTIBODY-IDENTIFICATION-TECHNICAL-TEST

    CPT 86022: Platelet Antibody Detection and Identification

    CPT-86023-PLATELET-ASSOCIATED-IMMUNOGLOBULIN-DETECTION

    CPT 86023: Platelet-Associated Immunoglobulin Assay

    Showing 1–10 of 199

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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