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    v1.0.30
    OpenPayerBilling CodesQualitative or Semiquantitative ImmunoassaysCPT cpt-86631-chlamydia-antibody-serology-excluding-igm
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    CPT 86631: Chlamydia Antibody Test (Serum)

    CPT code 86631 describes a laboratory serologic antibody test for Chlamydia, performed by a lab analyst on serum to detect chlamydial antibodies (excluding IgM), used in evaluating past or ongoing chlamydial infection; service type: clinical laboratory test (serology); typical site of service: clinical laboratory or hospital laboratory (blood/serum testing).

    For related coverage guidance, see recent payer policy updates: Allergy Testing, Including Selected Blood, Serum and Cellular Testing and Toxicity Testing Corporate Medical Policy, Allergy Testing and Injections, Allergy Testing.

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    Clinical & Coding Specifications

    Clinical Context

    A 24-year-old sexually active female presents to a primary care clinic with symptoms of urethral discomfort and abnormal vaginal discharge. The clinician obtains a sexual history, performs a pelvic exam, and orders laboratory testing to evaluate for common sexually transmitted infections. A blood specimen is collected and sent to the clinical laboratory for serologic testing for chlamydia antibodies excluding IgM (86631) when the clinician suspects a prior or chronic Chlamydia trachomatis infection, when nucleic acid amplification testing (NAAT) is unavailable or inconclusive, or when serologic evaluation is needed for epidemiologic or confirmatory purposes. The laboratory analyst performs the technical assay on serum, documents analytic results in the laboratory information system, and reports results to the ordering provider. Typical site of service includes outpatient clinics, hospital outpatient labs, community health centers, and reference laboratories. Turnaround time varies by lab method; results support treatment decisions, partner notification, or further diagnostic workup such as NAAT from urine or genital swabs.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    86631Tests for Chlamydia trachomatis antibody, excludes IgM — technical lab test performed on serumPrimary code for serologic testing for chlamydial antibodies (technical component).
    87320Infectious agent antigen detection by immunoassay, multiple-step method; Chlamydia trachomatisCommon alternative or complementary test using specimen NAAT/antigen methods for active infection.
    87491Infectious agent detection by nucleic acid (DNA or RNA); Chlamydia trachomatis, amplified probe technique, direct probe or NAAT for single compoundFrequently used frontline diagnostic test for acute genital chlamydial infection — often ordered alongside or instead of serology.
    87070Culture, bacterial; any other source except urine, blood or stool, aerobic, with isolation and presumptive identificationMay be used when culture-based methods are required for non-genital sites such as conjunctival or respiratory specimens.
    86580Skin test; tuberculosis, intradermal (Mantoux)Not directly related to chlamydia testing; included only if broader STI or infectious disease panels are performed — otherwise Data not available in the input.

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207Q00000X
    207R00000X
    208D00000X
    3336C0002X
    207L00000X
    261QP2400X
    2255R0406X
    207RH0002X

    Related ICD-10-CM Codes

    26 rows

    ICD-10-CM CodeDescription
    A54.00Gonococcal infection of lower genitourinary tract, unspecified
    A54.01Gonococcal cystitis and urethritis, unspecified
    A54.02Gonococcal vulvovaginitis, unspecified
    A54.03Gonococcal cervicitis, unspecified
    A56.00Chlamydial infection of lower genitourinary tract, unspecified
    A56.01Chlamydial cystitis and urethritis
    A56.09Other chlamydial infection of lower genitourinary tract
    A64Unspecified sexually transmitted disease
    A74.0Chlamydial conjunctivitis
    A74.9Chlamydial infection, unspecified

    Showing 1–10 of 26

    Related Payer Policy Updates

    Specialty: Allergy/Clinical Immunology1 / 3

    10 rows

    PolicyPayerEffective Date
    Allergy Testing, Including Selected Blood, Serum and Cellular Testing and Toxicity Testing Corporate Medical Policybcbsvermont2026-11-01
    Allergy Testing and InjectionsUnitedHealthcare2026-10-01
    Allergy TestingProvidence Health Plan2026-10-01
    Diagnosis of Idiopathic Environmental IntoleranceOscar Health2026-10-01
    Allergen Testingblue cross blue shield - louisiana2026-09-15
    Allergen TestingBlue Cross Blue Shield - New Mexico2026-09-04
    ALLERGY TESTING / IMMUNOTHERAPYpriority_health_medicare2026-09-01
    Hereditary Angioedema - EkterlyCigna2026-08-15
    Omalizumab products (Xolair, Omlyclo) coveragePremera Bluecross2026-08-01
    Omalizumab Products (Xolair, Omlyclo) coveragePremera Bluecross2026-08-01

    Related Codes

    86803-QUALITATIVE-OR-SEMIQUANTITATIVE-IMMUNOASSAYS-HEPATITIS-C

    CPT 86803: Hepatitis C Antibody Immunoassay in Serum

    CPT-86000-FEBRILE-AGGLUTININS-SEROLOGIC-TEST

    CPT 86000: Febrile Agglutinins (Serologic Agglutination) Test

    CPT-86001-ALLERGEN-SPECIFIC-IGG-LABORATORY-TEST

    CPT 86001: Allergen-Specific IgG Assay, Technical Component

    CPT-86003-ALLERGEN-SPECIFIC-IGE-ASSAY-TECHNICAL

    CPT 86003: Allergen‑Specific IgE Assay Using Crude Allergen Extract

    CPT-86005-MULTI-ALLERGEN-IGE-SCREENING-QUALITATIVE

    CPT 86005: Multi-Allergen Allergen-Specific IgE Screening

    CPT-86008-ALLERGEN-COMPONENT-SPECIFIC-IGE-ASSAY

    CPT 86008: Allergen Component–Specific IgE Assay

    CPT-86015-ANTI-ACTIN-SMOOTH-MUSCLE-ANTIBODY-ASMA

    CPT 86015: Actin (Smooth Muscle) Antibody (ASMA) Immunoassay

    CPT-86021-LEUKOCYTE-ANTIBODY-IDENTIFICATION-LAB-TECHNICAL

    CPT 86021: Leukocyte Antibody Identification Laboratory Test

    CPT-86022-PLATELET-ANTIBODY-IDENTIFICATION-TECHNICAL-TEST

    CPT 86022: Platelet Antibody Detection and Identification

    CPT-86023-PLATELET-ASSOCIATED-IMMUNOGLOBULIN-DETECTION

    CPT 86023: Platelet-Associated Immunoglobulin Assay

    Showing 1–10 of 199

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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