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CPT 86364: Tissue Transglutaminase Antibody (TTG) Serology
CPT code 86364 represents a laboratory serologic test for tissue transglutaminase (TTG) antibodies, such as TTG IgG or TTG IgA, commonly performed by immunoassay methods like ELISA. This test is clinically important because detection of TTG antibodies supports the diagnosis of celiac disease and can assist in monitoring response to a gluten-free diet. Nationally, TTG antibody testing is a widely used first-line serologic screen in patients with suspected celiac disease and in follow-up care.
Key payers covered in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of what CPT code 86364 represents, the clinical context for its use, and typical service settings. The publication outlines common modifiers associated with laboratory services and provides benchmarks and policy-relevant updates where available. The content also summarizes clinical indications and how results are used in diagnostic pathways and patient monitoring. Data not available in the input is clearly noted where applicable.
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Billing Code Overview
CPT code 86364 describes a laboratory test that detects tissue transglutaminase (TTG) antibodies in a specimen such as serum, for example TTG IgG or TTG IgA. Common methods for performing this assay include immunoassays such as enzyme–linked immunosorbent assay (ELISA). The presence of TTG antibodies supports the diagnosis of celiac disease, an autoimmune disorder that causes inflammation of the small intestine in response to dietary gluten. Test results may also help clinicians monitor patient adherence to treatment.
Service type: Laboratory serologic immunoassay for TTG antibodies
Typical site of service: Clinical laboratory or hospital laboratory; outpatient specimen collection sites