CPT code 86308 describes a serologic immunoassay used to screen serum or plasma for heterophile antibodies indicative of infectious mononucleosis. This widely used laboratory screening test supports initial diagnostic evaluation of patients with clinical signs consistent with mono and can influence subsequent confirmatory testing and clinical management. Nationally, accurate coding and consistent coverage policies for 86308 affect laboratory billing, claims processing, and epidemiologic tracking of mono diagnoses.

Key payers discussed include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a compact overview of clinical context for the test, typical sites of service where it is performed, and the types of reimbursement and billing considerations commonly encountered across major payers. The report summarizes coverage patterns, allowed service settings, and common billing modifiers used with laboratory immunoassays where available. It also outlines how 86308 fits into diagnostic pathways for suspected infectious mononucleosis and what benchmarks and policy updates are most relevant for laboratory administrators and billing teams.

Data not available in the input for specific payer rates, ICD-10 pairings, and associated taxonomies.