CPT code 86063 denotes the technical laboratory test to analyze serum for the presence of antistreptolysin O (ASO), a serologic marker used in assessing recent or prior streptococcal infection. Nationally, ASO testing supports diagnostic evaluation for post-streptococcal complications and rheumatologic or infectious disease workups, making accurate lab coding and billing important for care documentation and claims processing. Key payers relevant to coverage and reimbursement considerations include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare.

This publication provides a concise review of CPT code 86063: its clinical role, typical sites of service, and operational context for laboratories and billing teams. Readers will find benchmark framing for payer coverage (where available), common billing modifiers and service-line context, and the clinical indications that typically prompt ASO testing. The report also notes areas where input data is not available and highlights where clinicians and billing staff should consult payer-specific policies or local laboratory protocols for authorization, bundling, or documentation requirements.

Intended for laboratory managers, medical coders, and policy analysts, the article organizes essential information for efficient claim submission and clinical communication around ASO serology testing using CPT code 86063.