Summary & Overview
CPT 83570: Isocitric Dehydrogenase (IDH) Enzyme Assay for Liver Function
CPT code 83570 identifies a laboratory assay that measures isocitric dehydrogenase (IDH), an enzyme assessed in the context of liver function testing and research. Nationally, this code captures specialized biochemical testing typically performed in research or clinical laboratory environments and can be relevant for clinical studies, advanced diagnostic workups, and translational research programs.
Key payers covered in the analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of the clinical purpose of the test, common payer coverage considerations, and the service context for claims processing. The publication outlines benchmarks and coding practice context where available, summarizes payer coverage patterns, and highlights how the test is positioned within laboratory service lines.
The report provides clinical context for when an IDH assay may be ordered, typical site-of-service expectations, and the administrative coding considerations that affect billing and claims adjudication. Data not available in the input is noted where payer-specific policies, reimbursement rates, or ICD-10 linkage information were not provided.
Billing Code Overview
CPT code 83570 describes a laboratory measurement of the enzyme isocitric dehydrogenase (IDH), performed primarily in a research laboratory setting as a test related to liver function. The service type is laboratory enzymology / biochemical assay, and the typical site of service is a research or clinical laboratory rather than a point-of-care or clinician office setting.
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Clinical & Coding Specifications
Clinical Context
A 56-year-old patient with chronic liver disease and elevated liver enzymes is referred for laboratory assessment of hepatic metabolic function. The laboratory performs an enzymatic assay measuring isocitrate dehydrogenase (IDH) activity to help characterize hepatocellular injury and metabolic disturbances. The specimen is a venous blood draw collected in the outpatient clinic or hospital phlebotomy unit, transported to a central clinical chemistry or research laboratory, and processed by a clinical laboratory scientist or lab analyst. Results are reported in the electronic health record and used by the treating hepatologist or internist to support diagnosis, monitor progression, or guide additional testing (for example, metabolic panels, imaging, or molecular testing). Typical site of service is an outpatient laboratory or hospital clinical laboratory. Typical patient scenario includes evaluation of unexplained transaminitis, monitoring of patients with known metabolic liver disease, or investigational/research contexts assessing IDH isoenzyme activity.
Coding Specifications
| Modifier | Description | When to Use |
|---|---|---|
26 | Professional component | Use when reporting only the professional interpretation component if split billing applies and the lab provides interpretation separate from technical testing. |
52 |