CPT code 84163 describes a laboratory assay to quantitate pregnancy-associated plasma protein A (PAPP-A), a first-trimester maternal serum test used in prenatal screening to assess risk for Down syndrome (trisomy 21) and other pregnancy complications; service type: clinical laboratory testing, typical site of service: outpatient laboratory or hospital laboratory draw associated with prenatal care.

For related coverage guidance, see recent payer policy updates: Salivary Hormone Testing, Parathyroid Hormone, Phosphorus, Calcium, and Magnesium Testing, Bone Turnover Markers Testing.