Summary & Overview
CPT 82154: Androstanediol Glucuronide Quantitative Assay
CPT code 82154 represents a quantitative laboratory assay for androstanediol glucuronide, a metabolite used to assess androgen activity. This test is clinically relevant for evaluating hirsutism in females and androgen disorders in males, informing diagnostic workups for endocrine and reproductive health issues. Nationally, accurate laboratory measurement of androgen metabolites supports appropriate clinical decision-making and can affect downstream diagnostic and treatment pathways.
Key payers discussed include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. The publication provides readers with an operational and policy-focused overview: clinical context for use of the assay, typical sites of service, payer coverage considerations, and benchmarking where available. It also summarizes common billing and coding factors relevant to claims processing for this laboratory service.
Readers will learn the clinical indications tied to the assay, how the service is classified for billing purposes, and what to expect in payer interactions and claim adjudication at a national level. Data not available in the input will be explicitly marked where applicable.
Billing Code Overview
CPT code 82154 measures the quantitative level of androstanediol glucuronide, a steroid metabolite used in clinical evaluation of androgen status. The test is typically ordered when assessing excessive hair growth (hirsutism) in females or evaluating androgen-related disorders in males.
Service Type: Laboratory test — quantitative steroid assay
Typical Site of Service: Clinical laboratory or hospital outpatient laboratory
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Clinical & Coding Specifications
Clinical Context
A 28-year-old woman presents to an endocrinology clinic with progressive facial and body hair growth, irregular menses, and difficulty conceiving. The clinician suspects hyperandrogenism and orders a laboratory panel that includes measurement of androstanediol glucuronide to assess peripheral androgen metabolism and tissue-level androgen activity. A blood or serum sample is collected in the outpatient phlebotomy area and sent to the reference laboratory. The laboratory analyst performs quantitative measurement of 82154 (androstanediol glucuronide). Results are returned to the ordering provider and integrated with serum testosterone, DHEA-S, LH/FSH, and clinical findings to support diagnosis and management of conditions such as polycystic ovary syndrome, nonclassical congenital adrenal hyperplasia, or androgen-secreting tumors. Typical sites of service include outpatient clinic, hospital outpatient laboratory, and reference commercial laboratories. The typical workflow involves: order entry by the clinician, specimen collection by phlebotomy, specimen processing and analysis in the lab, result reporting to the electronic health record, and clinician interpretation in follow-up visit or telehealth encounter.
Coding Specifications
| Modifier | Description | When to Use |
|---|---|---|
26 | Professional component | When billing only the professional interpretation/reporting component if the lab separates technical and professional charges |