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    v1.0.28
    OpenPayerBilling CodesChemistry ProceduresCPT cpt-82154-androstanediol-glucuronide-quantitative-assay
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    CPT 82154: Quantitative Androstanediol Glucuronide Assay

    CPT code 82154 is a laboratory test that measures the quantitative level of androstanediol glucuronide, used in the clinical evaluation of hyperandrogenism in females (excessive hair growth) and androgen disorders in males; the service is a serum or urine endocrine laboratory assay typically performed in clinical laboratories or hospital lab settings for diagnostic workup and endocrine evaluation.

    For related coverage guidance, see recent payer policy updates: Salivary Hormone Testing, Parathyroid Hormone, Phosphorus, Calcium, and Magnesium Testing, Bone Turnover Markers Testing.

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    Clinical & Coding Specifications

    Clinical Context

    A 28-year-old woman presents to an endocrinology clinic with progressive facial and body hair growth, irregular menses, and difficulty conceiving. The clinician suspects hyperandrogenism and orders a laboratory panel that includes measurement of androstanediol glucuronide to assess peripheral androgen metabolism and tissue-level androgen activity. A blood or serum sample is collected in the outpatient phlebotomy area and sent to the reference laboratory. The laboratory analyst performs quantitative measurement of 82154 (androstanediol glucuronide). Results are returned to the ordering provider and integrated with serum testosterone, DHEA-S, LH/FSH, and clinical findings to support diagnosis and management of conditions such as polycystic ovary syndrome, nonclassical congenital adrenal hyperplasia, or androgen-secreting tumors. Typical sites of service include outpatient clinic, hospital outpatient laboratory, and reference commercial laboratories. The typical workflow involves: order entry by the clinician, specimen collection by phlebotomy, specimen processing and analysis in the lab, result reporting to the electronic health record, and clinician interpretation in follow-up visit or telehealth encounter.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    80053Comprehensive metabolic panelBaseline metabolic testing often ordered concurrently to evaluate overall health and medication effects
    84403Thyroid stimulating hormone (TSH)Thyroid dysfunction can mimic or exacerbate menstrual irregularities and hair changes; often ordered in the endocrine workup
    84402Thyroxine; total T4Additional thyroid assessment commonly paired with TSH in endocrine evaluation
    82607Testosterone; freeMeasurement of serum testosterone complements 82154 to assess androgen status
    84436EstradiolOften ordered in reproductive endocrine evaluation to interpret menstrual irregularities and androgen effects

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207RH0000XHematology (Internal Medicine) PhysicianAn internist with additional training who specializes in diseases of the blood, spleen and lymph. This specialist treats conditions such as anemia, cl…
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    208000000XPediatrics PhysicianA pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
    207K00000XAllergy & Immunology PhysicianAn allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
    275N00000XMedicare Defined Swing Bed Hospital UnitA unit of a hospital that has a Medicare provider agreement and has been granted approval from HCFA to provide post-hospital extended care services an…
    207QA0401XAddiction Medicine (Family Medicine) PhysicianA family medicine physician who specializes in the diagnosis and treatment of addictions.
    385HR2060XChild Intellectual and/or Developmental Disabilities Respite CareA facility or distinct part of a facility that provides short term, residential care to children diagnosed with intellectual and/or developmental disa…
    207PS0010XSports Medicine (Emergency Medicine) PhysicianAn emergency physician with special knowledge in sports medicine is responsible for continuous care in the field of sports medicine, not only for the …

    Related ICD-10-CM Codes

    25 rows

    ICD-10-CM CodeDescription
    E03.9Hypothyroidism, unspecified
    E16.1Other hypoglycemia
    E16.4Increased secretion of gastrin
    E22.0Acromegaly and pituitary gigantism
    E23.0Hypopituitarism
    E24.9Cushing's syndrome, unspecified
    E28.1Androgen excess
    E28.2Polycystic ovarian syndrome
    E28.8Other ovarian dysfunction
    E28.9Ovarian dysfunction, unspecified

    Showing 1–10 of 25

    Related Payer Policy Updates

    Specialty: Endocrinology1 / 3

    10 rows

    PolicyPayerEffective Date
    Salivary Hormone TestingOscar Health2026-10-01
    Parathyroid Hormone, Phosphorus, Calcium, and Magnesium TestingOscar Health2026-10-01
    Bone Turnover Markers TestingOscar Health2026-10-01
    Testosterone — Coverage Criteria for Measurement and MonitoringOscar Health2026-10-01
    Diabetes Mellitus Testing — Coverage CriteriaOscar Health2026-10-01
    Thyroid Disease TestingOscar Health2026-10-01
    Thyroid Disease Testingblue cross blue shield - louisiana2026-09-15
    Thyroid Disease TestingBlue Cross Blue Shield - New Mexico2026-09-04
    Parathyroid Hormone, Phosphorous, Calcium and Magnesium TestingBlue Cross Blue Shield - New Mexico2026-09-04
    Testosterone laboratory testing and managementPremera Bluecross2026-09-04

    Related Codes

    CPT-82009-KETONE-BODIES-QUALITATIVE-TEST

    CPT 82009: Qualitative Ketone Bodies Test

    CPT-82010-QUANTITATIVE-KETONE-BODIES-ASSAY-SERUM-PLASMA

    CPT 82010: Quantitative Ketone Bodies in Serum or Plasma

    CPT-82013-ACETYLCHOLINESTERASE-QUANTITATIVE-ASSAY

    CPT 82013: Quantitative Acetylcholinesterase (Acetylhydrolase) Assay

    CPT-82016-QUALITATIVE-ACYLCARNITINES-METABOLIC-SCREEN

    CPT 82016: Qualitative Acylcarnitines, Plasma/Serum/Urine

    CPT-82017-QUANTITATIVE-ACYLCARNITINE-ANALYSIS

    CPT 82017: Quantitative Acylcarnitine Analysis

    CPT-82024-QUANTITATIVE-CORTICOTROPIN-ACTH-ASSAY

    CPT 82024: Adrenocorticotropic Hormone (ACTH) Quantitative Assay

    CPT-82030-QUANTITATIVE-CAMP-PLASMA-URINE-ASSAY

    CPT 82030: Quantitative cyclic AMP assay on plasma or urine

    CPT-82040-QUANTITATIVE-ALBUMIN-MEASUREMENT

    CPT 82040: Quantitative Albumin Measurement

    CPT-82042-QUANTITATIVE-ALBUMIN-NONBLOOD-FLUID

    CPT 82042: Albumin Quantitation in Non-Blood Body Fluid

    CPT-82043-URINE-ALBUMIN-QUANTITATION-KIDNEY-DISEASE

    CPT 82043: Urine Albumin Quantitative Assay

    Showing 1–10 of 411

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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