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    v1.0.28
    OpenPayerBilling CodesChemistry ProceduresCPT cpt-82775-galt-activity-assay-galactosemia
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    CPT 82775: Galactose-1-Phosphate Uridyl Transferase Assay

    CPT code 82775 describes a laboratory assay measuring galactose-1-phosphate uridyl transferase (GALT) activity in a blood sample, typically performed after an abnormal newborn screen or to monitor adherence to a dietary therapy for galactosemia; the service is a quantitative enzymatic laboratory test and the typical site of service is an ambulatory clinical laboratory or hospital laboratory where blood specimens are processed and analyzed.

    For related coverage guidance, see recent payer policy updates: Salivary Hormone Testing, Parathyroid Hormone, Phosphorus, Calcium, and Magnesium Testing, Bone Turnover Markers Testing.

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    Clinical & Coding Specifications

    Clinical Context

    A newborn infant with an abnormal state newborn screen for galactosemia is referred to the hospital laboratory for confirmatory testing. The infant is 3 days old, has poor feeding and mild jaundice. The clinician orders measurement of galactose-1-phosphate uridyl transferase activity from a heel-stick or venous blood sample to confirm classic galactosemia. The specimen is collected into appropriate anticoagulant tube, labeled with patient identifiers and sent with a requisition noting the abnormal screen result and relevant clinical history. The laboratory performs the enzymatic assay, documents results in the laboratory information system, and releases a report to the ordering pediatrician and the newborn metabolic disorder specialist. If the diagnosis is confirmed, the care team initiates dietary galactose restriction and schedules serial monitoring tests to assess enzyme activity or compliance. This test may also be used in older infants or children on dietary therapy to monitor compliance or enzyme activity changes.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    82775Galactose-1-phosphate uridyltransferase (GALT) assayPrimary enzymatic assay to measure GALT activity for confirmation of galactosemia or monitoring therapy.
    81025Urinalysis, reagent strip; multi-test automatedPerformed to assess for reducing substances in urine in suspected galactosemia screening.
    82040Drug assay, qualitative; multiple drug classesNot directly related; omitted.
    82947Glucose; quantitative, blood (except reagent strip)Used to monitor hypoglycemia in newborns with metabolic disease during evaluation.
    81406Targeted genomic sequence analysis (e.g., GALT gene)Molecular confirmatory testing for mutations in the GALT gene performed after abnormal enzymatic assay.
    82962Glucose, blood, reagent stripPoint-of-care glucose testing commonly used during neonatal evaluation and monitoring.

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207K00000XAllergy & Immunology PhysicianAn allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    363A00000XPhysician AssistantA physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
    172P00000XNaprapathNaprapathy means a branch of medicine that focuses on the evaluation and treatment of neuron-muscular conditions. Doctors of naprapathy are connectiv…
    111NI0900XInternist ChiropractorThe chiropractic internist may serve as a primary care physician or may see patients referred from other providers for evaluation and co-management. E…
    224Y00000XClinical Exercise PhysiologistA Clinical Exercise Physiologist is a health care professional who is trained to work with patients with chronic disease where exercise training has b…
    207RM1200XMagnetic Resonance Imaging (MRI) Internal Medicine PhysicianThe NUCC recommends this code not be used. Choose a more appropriate code.<br/>
    163WX0200XOncology Registered NurseNursing Service Providers · Registered Nurse

    Related ICD-10-CM Codes

    21 rows

    ICD-10-CM CodeDescription
    E03.9Hypothyroidism, unspecified
    E16.2Hypoglycemia, unspecified
    E16.8Other specified disorders of pancreatic internal secretion
    E66.01Morbid (severe) obesity due to excess calories
    E66.9Obesity, unspecified
    E70.0Classical phenylketonuria
    E70.1Other hyperphenylalaninemias
    E74.01von Gierke disease
    E74.09Other glycogen storage disease
    E74.4Disorders of pyruvate metabolism and gluconeogenesis

    Showing 1–10 of 21

    Related Payer Policy Updates

    Specialty: Endocrinology1 / 3

    10 rows

    PolicyPayerEffective Date
    Salivary Hormone TestingOscar Health2026-10-01
    Parathyroid Hormone, Phosphorus, Calcium, and Magnesium TestingOscar Health2026-10-01
    Bone Turnover Markers TestingOscar Health2026-10-01
    Testosterone — Coverage Criteria for Measurement and MonitoringOscar Health2026-10-01
    Diabetes Mellitus Testing — Coverage CriteriaOscar Health2026-10-01
    Thyroid Disease TestingOscar Health2026-10-01
    Thyroid Disease Testingblue cross blue shield - louisiana2026-09-15
    Thyroid Disease TestingBlue Cross Blue Shield - New Mexico2026-09-04
    Parathyroid Hormone, Phosphorous, Calcium and Magnesium TestingBlue Cross Blue Shield - New Mexico2026-09-04
    Testosterone laboratory testing and managementPremera Bluecross2026-09-04

    Related Codes

    CPT-82009-KETONE-BODIES-QUALITATIVE-TEST

    CPT 82009: Qualitative Ketone Bodies Test

    CPT-82010-QUANTITATIVE-KETONE-BODIES-ASSAY-SERUM-PLASMA

    CPT 82010: Quantitative Ketone Bodies in Serum or Plasma

    CPT-82013-ACETYLCHOLINESTERASE-QUANTITATIVE-ASSAY

    CPT 82013: Quantitative Acetylcholinesterase (Acetylhydrolase) Assay

    CPT-82016-QUALITATIVE-ACYLCARNITINES-METABOLIC-SCREEN

    CPT 82016: Qualitative Acylcarnitines, Plasma/Serum/Urine

    CPT-82017-QUANTITATIVE-ACYLCARNITINE-ANALYSIS

    CPT 82017: Quantitative Acylcarnitine Analysis

    CPT-82024-QUANTITATIVE-CORTICOTROPIN-ACTH-ASSAY

    CPT 82024: Adrenocorticotropic Hormone (ACTH) Quantitative Assay

    CPT-82030-QUANTITATIVE-CAMP-PLASMA-URINE-ASSAY

    CPT 82030: Quantitative cyclic AMP assay on plasma or urine

    CPT-82040-QUANTITATIVE-ALBUMIN-MEASUREMENT

    CPT 82040: Quantitative Albumin Measurement

    CPT-82042-QUANTITATIVE-ALBUMIN-NONBLOOD-FLUID

    CPT 82042: Albumin Quantitation in Non-Blood Body Fluid

    CPT-82043-URINE-ALBUMIN-QUANTITATION-KIDNEY-DISEASE

    CPT 82043: Urine Albumin Quantitative Assay

    Showing 1–10 of 411

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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