Summary & Overview
CPT 82671: Estrogen Fractionation (Estradiol, Estrone)
CPT code 82671 represents quantitative measurement of estrogen fractions, primarily estradiol and estrone, with estriol as a minor component. This laboratory assay is used to assess serum estrogen levels for clinical evaluation of hormonal status in females, with particular relevance in reproductive health, endocrine disorders, and select diagnostic evaluations. Nationally, estrogen assays inform clinical decision-making across outpatient clinics, specialty practices, and hospital laboratories.
Key payers covered in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find an overview of the clinical context for CPT code 82671, common places of service, and the role of the assay in care pathways. The publication provides benchmark information, coding considerations, and a summary of payer coverage patterns where available. It also outlines typical service settings and clinical scenarios in which estrogen fractionation is requested.
Data not available in the input: specific payer policy details, associated taxonomies, ICD-10 diagnosis mappings, related CPT or HCPCS codes, and service-line level billing details.
Billing Code Overview
CPT code 82671 measures the fractions of circulating estrogens, primarily estradiol and estrone, with a smaller fraction of estriol that is significant during pregnancy. The assay quantifies the major serum estrogen fractions to evaluate hormonal status in patients, most commonly in women.
Service type: Laboratory testing — quantitative estrogen fractionation.
Typical site of service: Clinical laboratory or hospital laboratory performing serum hormone analysis.
Clinical & Coding Specifications
Clinical Context
A 34-year-old female presents to an outpatient women's health clinic with irregular menses and symptoms of androgen excess and low libido. Her gynecologist orders serum estrogen fractionation to assess circulating levels of estradiol and estrone to help distinguish ovarian versus peripheral sources of estrogen and to guide endocrine management. Blood is drawn in the outpatient phlebotomy area; the specimen is sent to the clinical laboratory where a medical technologist performs quantitative measurement of estradiol and estrone using an immunoassay or mass spectrometry platform. Results are reported in nanograms per milliliter or picograms per milliliter and routed to the ordering provider for interpretation and treatment planning. Typical sites of service include outpatient physician offices, ambulatory surgery centers (if perioperative assessment is needed), hospital outpatient laboratories, and reference clinical laboratories. The workflow includes order entry, patient preparation, specimen collection, laboratory processing and analysis, verification by clinical laboratory personnel, and transmission of results to the ordering clinician for management decisions.
Coding Specifications
| Modifier | Description | When to Use |
|---|---|---|
26 | Professional component | Use when billing only the professional interpretation/consultative component of the laboratory testing service when applicable under split billing arrangements. |