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    v1.0.28
    OpenPayerBilling CodesChemistry ProceduresCPT cpt-82384-catecholamines-fractionation-epinephrine-norepinephrine-dopamine
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    CPT 82384: Catecholamine Fractionation (Epinephrine, Norepinephrine, Dopamine)

    CPT code 82384 reports measurement of catecholamines with fractionation for epinephrine, norepinephrine, and dopamine, typically performed on a 24‑hour urine or plasma sample; this is a clinical laboratory service used to evaluate suspected catecholamine-secreting tumors or autonomic disorders and is usually provided in an outpatient laboratory or hospital clinical lab setting.

    For related coverage guidance, see recent payer policy updates: Salivary Hormone Testing, Parathyroid Hormone, Phosphorus, Calcium, and Magnesium Testing, Bone Turnover Markers Testing.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a 45–60-year-old adult referred to endocrinology for evaluation of suspected catecholamine-secreting tumor (pheochromocytoma or paraganglioma) after presenting with episodic hypertension, palpitations, severe headaches, diaphoresis, or unexplained tachycardia. The clinical workflow begins with outpatient history, physical exam, and measurement of plasma free metanephrines or a 24-hour urine collection for fractionated catecholamines and metanephrines. For CPT 82384, a 24-hour urine sample or plasma specimen is collected per laboratory protocol, labeled with patient identifiers and collection period, and sent to a clinical chemistry laboratory. The analyst performs fractionation for epinephrine, norepinephrine, and dopamine to quantify catecholamine levels. Results are reviewed by the ordering clinician (often an endocrinologist or primary care physician); abnormal elevations prompt biochemical confirmation, repeat testing if needed, medication review (e.g., interfering drugs), and imaging (CT/MRI or functional scans) for tumor localization. Typical sites of service include outpatient clinics, hospital inpatient units, emergency departments for acute presentations, and independent clinical laboratories that process endocrine assays. Specimen handling and timing (resting state, off interfering medications when possible) are important for accurate interpretation.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    81025Urine pregnancy test, by visual color comparison methodsPerformed prior to sample collection in women of childbearing age when clinically indicated
    82043Assay of urine metanephrines (fractionated)Often ordered alongside catecholamine fractionation to improve detection of pheochromocytoma/paraganglioma
    80053Comprehensive metabolic panel (CMP)Common baseline laboratory panel ordered concurrently to assess metabolic status and renal function before testing or imaging
    81002Urinalysis, non-automated, without microscopyMay be performed on the same urine collection to document sample characteristics and rule out contamination
    84132Assay of urine creatinineOften used to normalize 24-hour urine catecholamine concentrations or verify completeness of collection

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207RC0000XCardiovascular Disease PhysicianAn internist who specializes in diseases of the heart and blood vessels and manages complex cardiac conditions such as heart attacks and life-threaten…
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    163W00000XRegistered Nurse(1) A registered nurse is a person qualified by graduation from an accredited nursing school (depending upon schooling, a registered nurse may receive…
    207R00000XInternal Medicine PhysicianA physician who provides long-term, comprehensive care in the office and the hospital, managing both common and complex illness of adolescents, adults…
    207K00000XAllergy & Immunology PhysicianAn allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
    2279G0305XGeriatric Care Registered Respiratory TherapistCare of older patients who have age and/or disease related decremental pulmonary changes. Diagnosis and treatment is very important for this group si…
    163WH1000XHospice Registered NurseNursing Service Providers · Registered Nurse
    343900000XNon-emergency Medical Transport (VAN)A land vehicle with a capacity to meet special height, clearance, access, and seating, for the conveyance of persons in non-emergency situations. The …

    Related ICD-10-CM Codes

    28 rows

    ICD-10-CM CodeDescription
    C74.90Malignant neoplasm of unspecified part of unspecified adrenal gland
    C74.91Malignant neoplasm of unspecified part of right adrenal gland
    E05.00Thyrotoxicosis with diffuse goiter without thyrotoxic crisis or storm
    E16.0Drug-induced hypoglycemia without coma
    E16.2Hypoglycemia, unspecified
    E21.0Primary hyperparathyroidism
    E21.2Other hyperparathyroidism
    E27.5Adrenomedullary hyperfunction
    E78.5Hyperlipidemia, unspecified
    F32.9Major depressive disorder, single episode, unspecified

    Showing 1–10 of 28

    Related Payer Policy Updates

    Specialty: Endocrinology1 / 3

    10 rows

    PolicyPayerEffective Date
    Salivary Hormone TestingOscar Health2026-10-01
    Parathyroid Hormone, Phosphorus, Calcium, and Magnesium TestingOscar Health2026-10-01
    Bone Turnover Markers TestingOscar Health2026-10-01
    Testosterone — Coverage Criteria for Measurement and MonitoringOscar Health2026-10-01
    Diabetes Mellitus Testing — Coverage CriteriaOscar Health2026-10-01
    Thyroid Disease TestingOscar Health2026-10-01
    Thyroid Disease Testingblue cross blue shield - louisiana2026-09-15
    Thyroid Disease TestingBlue Cross Blue Shield - New Mexico2026-09-04
    Parathyroid Hormone, Phosphorous, Calcium and Magnesium TestingBlue Cross Blue Shield - New Mexico2026-09-04
    Testosterone laboratory testing and managementPremera Bluecross2026-09-04

    Related Codes

    CPT-82009-KETONE-BODIES-QUALITATIVE-TEST

    CPT 82009: Qualitative Ketone Bodies Test

    CPT-82010-QUANTITATIVE-KETONE-BODIES-ASSAY-SERUM-PLASMA

    CPT 82010: Quantitative Ketone Bodies in Serum or Plasma

    CPT-82013-ACETYLCHOLINESTERASE-QUANTITATIVE-ASSAY

    CPT 82013: Quantitative Acetylcholinesterase (Acetylhydrolase) Assay

    CPT-82016-QUALITATIVE-ACYLCARNITINES-METABOLIC-SCREEN

    CPT 82016: Qualitative Acylcarnitines, Plasma/Serum/Urine

    CPT-82017-QUANTITATIVE-ACYLCARNITINE-ANALYSIS

    CPT 82017: Quantitative Acylcarnitine Analysis

    CPT-82024-QUANTITATIVE-CORTICOTROPIN-ACTH-ASSAY

    CPT 82024: Adrenocorticotropic Hormone (ACTH) Quantitative Assay

    CPT-82030-QUANTITATIVE-CAMP-PLASMA-URINE-ASSAY

    CPT 82030: Quantitative cyclic AMP assay on plasma or urine

    CPT-82040-QUANTITATIVE-ALBUMIN-MEASUREMENT

    CPT 82040: Quantitative Albumin Measurement

    CPT-82042-QUANTITATIVE-ALBUMIN-NONBLOOD-FLUID

    CPT 82042: Albumin Quantitation in Non-Blood Body Fluid

    CPT-82043-URINE-ALBUMIN-QUANTITATION-KIDNEY-DISEASE

    CPT 82043: Urine Albumin Quantitative Assay

    Showing 1–10 of 411

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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