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    v1.0.28
    OpenPayerBilling CodesChemistry ProceduresCPT cpt-82103-alpha-1-antitrypsin-quantitative
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    CPT 82103: Alpha-1-Antitrypsin Quantitative, Serum/Plasma

    CPT code 82103 reports a quantitative measurement of total alpha‑1‑antitrypsin in serum or plasma, used to detect hereditary deficiency and as an indicator in assessing chronic obstructive lung disease; the service is a clinical laboratory test typically performed in hospital or outpatient laboratory settings (phlebotomy specimen collection and lab analysis).

    For related coverage guidance, see recent payer policy updates: Diabetic Supplies, Radiofrequency Ablation for Thyroid Nodules, Continuous Glucose Monitoring and Insulin Delivery for Managing Diabetes (for Idaho Only).

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 52-year-old patient with a history of early-onset emphysema and persistent dyspnea is seen in a pulmonary clinic. The pulmonologist orders a quantitative serum alpha-1-antitrypsin assay to evaluate for alpha-1-antitrypsin deficiency as a genetic contributor to chronic obstructive pulmonary disease. A phlebotomy technician collects a serum or plasma specimen during the outpatient visit or at an affiliated laboratory site; the specimen is labeled and sent to the clinical laboratory. The laboratory analyst performs the 82103 test to measure the total alpha-1-antitrypsin concentration, documents the result in the laboratory information system, and the result is routed to the ordering provider. Results are used alongside pulmonary function testing, imaging, and family history to inform diagnosis, genetic counseling, and management planning. Typical sites of service include outpatient clinics, hospital outpatient laboratories, and independent clinical reference laboratories.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    80053Comprehensive metabolic panelCommon baseline laboratory panel performed in the same encounter to assess systemic health before or alongside specific testing.
    82785Alpha1-antitrypsin phenotyping, if performedUsed when phenotyping is done after quantitative measurement to identify specific variants.
    83036Hemoglobin; glycosylated (A1c)Example of another quantitative serum test commonly ordered in outpatient workups for chronic disease management.
    94060Bronchospasm evaluation (methacholine challenge)Pulmonary function test that may be part of the diagnostic workup for obstructive lung disease in conjunction with alpha-1-antitrypsin level.
    99397Periodic comprehensive preventive medicine reevaluation, established patientTypical outpatient visit code during which the test may be ordered and results reviewed.

    Related Modifiers

    5 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    207Q00000XFamily Medicine PhysicianFamily Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
    207K00000XAllergy & Immunology PhysicianAn allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
    363L00000XNurse Practitioner(1) A registered nurse provider with a graduate degree in nursing prepared for advanced practice involving independent and interdependent decision mak…
    2471R0002XRadiation Therapy Radiologic TechnologistA radiologic technologist who specializes in radiation therapy and is appropriately educated and trained, consistent with nationally recognized standa…
    163WR0006XRegistered Nurse First AssistantA perioperative registered nurse who works in collaboration with the surgeon and other health care team members to achieve optimal outcomes. The RNFA…
    225X00000XOccupational TherapistAn occupational therapist is a person who has graduated from an entry-level occupational therapy program accredited by the Accreditation Council for O…
    175F00000XNaturopathDiagnoses, treats, and cares for patients, using system of practice that bases treatment of physiological functions and abnormal conditions on natural…

    Related ICD-10-CM Codes

    29 rows

    ICD-10-CM CodeDescription
    E03.9Hypothyroidism, unspecified
    E66.01Morbid (severe) obesity due to excess calories
    E66.9Obesity, unspecified
    E78.5Hyperlipidemia, unspecified
    E88.01Alpha-1-antitrypsin deficiency
    E88.09Other disorders of plasma-protein metabolism, not elsewhere classified
    F17.210Nicotine dependence, cigarettes, uncomplicated
    I10Essential (primary) hypertension
    J42Unspecified chronic bronchitis
    J43.9Emphysema, unspecified

    Showing 1–10 of 29

    Related Payer Policy Updates

    Specialty: Endocrinology1 / 3

    10 rows

    PolicyPayerEffective Date
    Diabetic SuppliesCigna2026-10-15
    Radiofrequency Ablation for Thyroid NodulesCigna2026-10-15
    Continuous Glucose Monitoring and Insulin Delivery for Managing Diabetes (for Idaho Only)UnitedHealthcare2026-10-01
    Tzield (teplizumab-mzwv) CoverageUnitedHealthcare2026-10-01
    Continuous Glucose Monitoring and Insulin Delivery for Managing Diabetes (for Indiana Only)UnitedHealthcare2026-10-01
    Medical Necessity Guidelines Insulin PumpsMass General Brigham Health Plan2026-10-01
    Medical Necessity Guidelines: Continuous Glucose MonitorsMass General Brigham Health Plan2026-10-01
    Continuous Glucose MonitoringAmbetter Nevada2026-10-01
    Salivary Hormone TestingOscar Health2026-10-01
    Parathyroid Hormone, Phosphorus, Calcium, and Magnesium TestingOscar Health2026-10-01

    Related Codes

    CPT-82009-KETONE-BODIES-QUALITATIVE-TEST

    CPT 82009: Qualitative Ketone Bodies Test

    CPT-82010-QUANTITATIVE-KETONE-BODIES-ASSAY-SERUM-PLASMA

    CPT 82010: Quantitative Ketone Bodies in Serum or Plasma

    CPT-82013-ACETYLCHOLINESTERASE-QUANTITATIVE-ASSAY

    CPT 82013: Quantitative Acetylcholinesterase (Acetylhydrolase) Assay

    CPT-82016-QUALITATIVE-ACYLCARNITINES-METABOLIC-SCREEN

    CPT 82016: Qualitative Acylcarnitines, Plasma/Serum/Urine

    CPT-82017-QUANTITATIVE-ACYLCARNITINE-ANALYSIS

    CPT 82017: Quantitative Acylcarnitine Analysis

    CPT-82024-QUANTITATIVE-CORTICOTROPIN-ACTH-ASSAY

    CPT 82024: Adrenocorticotropic Hormone (ACTH) Quantitative Assay

    CPT-82030-QUANTITATIVE-CAMP-PLASMA-URINE-ASSAY

    CPT 82030: Quantitative cyclic AMP assay on plasma or urine

    CPT-82040-QUANTITATIVE-ALBUMIN-MEASUREMENT

    CPT 82040: Quantitative Albumin Measurement

    CPT-82042-QUANTITATIVE-ALBUMIN-NONBLOOD-FLUID

    CPT 82042: Albumin Quantitation in Non-Blood Body Fluid

    CPT-82043-URINE-ALBUMIN-QUANTITATION-KIDNEY-DISEASE

    CPT 82043: Urine Albumin Quantitative Assay

    Showing 1–10 of 411

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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