CPT 81458: Tumor Genomic Sequencing Panel with MSI and Copy Number Analysis
Commercial payers pay $882 on average nationally for this procedure.
CPT code 81458 describes a genomic sequence analysis panel performed on a tumor specimen to detect DNA sequence variants and copy number variants relevant to diagnosis and treatment of solid organ cancers and to assess microsatellite instability (MSI); service type: tumor genomic sequencing panel, typical site of service: clinical molecular diagnostics laboratory or hospital pathology lab.
For related coverage guidance, see recent payer policy updates: RTM Testing of Homocysteine Metabolism-Related Conditions, Multimarker Serum Testing Related to Ovarian Cancer, Genomic Profiling for Selecting Targeted Cancer Therapies.
Customize your policy alerts
Sign up for cpt 81458 policy alerts
Get alerted when payer policies referencing 81458 are released or updated.
Monitor payer policy activity
National Reimbursement Benchmarks
National commercial pricing for CPT 81458 centers around BUCA’s average commercial rate of $881.50, which functions as a market midpoint. Among named payers, Blue Cross Blue Shield has the highest mean at $959.00 while Aetna and UnitedHealth Group have lower means of $687.00 and $832.50 respectively; Cigna’s mean sits near $892.70. Dispersion around the interquartile range varies materially: Blue Cross Blue Shield’s IQR is $484.00 ($1,185.90 − $690.10), and Cigna’s IQR is $725.10 ($1,214.70 − $528.90), indicating wider variability for those contracts compared with Aetna’s tighter IQR of $306.00 ($858.00 − $525.00). UnitedHealth Group’s IQR of $607.50 ($1,046.40 − $439.50) falls in between.
Looking at extremes, Blue Cross Blue Shield and Cigna exhibit the widest interquartile spreads, suggesting greater regional or product-level variation in allowed amounts, while Aetna demonstrates the narrowest spread and therefore more concentrated commercial pricing. BUCA’s mean provides a practical benchmark for market positioning at $881.50, and payer-specific IQR comparisons highlight where negotiated rates are most and least dispersed across commercial contracts.