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    v1.0.30
    OpenPayerBilling CodesUrinalysis ProceduresCPT cpt-81099-unlisted-urine-procedure
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    CPT 81099: Unlisted Urine Procedure

    CPT code 81099 is an unlisted urine procedure code used to report laboratory procedures performed on urine specimens that do not have a specific CPT code; it covers miscellaneous urine analysis or testing services typically performed in a clinical laboratory or point-of-care setting and billed as a distinct laboratory service for documentation and claim submission purposes.

    For related coverage guidance, see recent payer policy updates: Vafseo (vadadustat) for anemia in CKD on dialysis, Metabolic Disorders - Cysteamine (Oral) Products for Individual and Family Plans, Kerendia (finerenone) — Coverage Criteria.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a 45-year-old adult who presents to an outpatient clinical laboratory or physician office with complaints of dysuria, frequency, or routine monitoring of a known urologic condition. A clean-catch urine specimen is collected and forwarded to the clinical laboratory. The laboratory analyst performs a specialized, non-routine urine test or assay that does not have a specific CPT code, such as a novel qualitative urine biomarker assay, a research-use-only urine analytic procedure adapted for clinical interpretation, or an uncommon urine sediment preparation/interpretation technique. The workflow includes specimen accessioning, preparation (centrifugation, concentration, or special staining), performance of the analytic method, documentation of results, and reporting to the ordering provider. Billing uses 81099 to report the specific urine procedure when no specific CPT code exists; global billing may include the technical component (TC) or be split with a professional component modifier (26) if the laboratory interpretation is separately billed. Common clinical settings are hospital outpatient laboratories, independent clinical laboratories, specialty urology clinics, and ambulatory surgical centers when urine testing accompanies other procedures.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    81002Urinalysis, by dipstick or tablet reagent; non-automated, with microscopyCommon preliminary test performed before or alongside specialized urine procedures; may lead to ordering of a non-routine urine assay billed with 81099.
    81020Urinalysis, by dipstick or tablet reagent; without microscopyOften performed in point-of-care settings as an initial screen prior to specialized urine testing.
    81025Urine pregnancy test, by visual color comparison methodsMay be performed concurrently to rule out pregnancy before certain urine-based diagnostic evaluations.
    81015Urinalysis; microscopic onlyMicroscopic examination of urine sediment frequently complements specialized testing billed with 81099.
    83986Osmolality, urineQuantitative urine assays such as osmolality are commonly ordered alongside specialized urine tests to assess renal concentrating ability; different specific CPT code, but often part of the same diagnostic workup.

    Related Modifiers

    5 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    122300000X
    2086S0102X
    207K00000X
    363L00000X
    193200000X
    207SC0300X
    246ZX2200X
    246ZI1000X

    Related ICD-10-CM Codes

    25 rows

    ICD-10-CM CodeDescription
    E86.0Dehydration
    N10Acute pyelonephritis
    N11.0Nonobstructive reflux-associated chronic pyelonephritis
    N12Tubulo-interstitial nephritis, not specified as acute or chronic
    N13.30Unspecified hydronephrosis
    N13.6Pyonephrosis
    N20.0Calculus of kidney
    N20.1Calculus of ureter
    N30.00Acute cystitis without hematuria
    N30.01Acute cystitis with hematuria

    Showing 1–10 of 25

    Related Payer Policy Updates

    Specialty: Nephrology1 / 3

    10 rows

    PolicyPayerEffective Date
    Vafseo (vadadustat) for anemia in CKD on dialysisCigna2026-08-15
    Metabolic Disorders - Cysteamine (Oral) Products for Individual and Family PlansCigna2026-08-15
    Kerendia (finerenone) — Coverage CriteriaBlue Cross Blue Shield - Iowa2026-08-05
    Voyxact (sibeprenlimab-szsl) — Prior authorization / medical necessity for primary IgA nephropathyColorado Rocky Mountain Health Plans2026-08-01
    Oxlumo (lumasiran) and Rivfloza (nedosiran) — Coverage Criteria (Ohio)Colorado Rocky Mountain Health Plans2026-08-01
    Korsuva (difelikefalin) — Medical Benefit Drug Coverage Criteria (Ohio)Colorado Rocky Mountain Health Plans2026-08-01
    Complement Inhibitors - EmpaveliCigna2026-08-01
    Tolvaptan (Jynarque)Cigna2026-08-01
    Nephrology - Filspari (sparsentan) coverageCigna2026-08-01
    Rivfloza (nedosiran) prior authorization for PH1UnitedHealthcare2026-08-01

    Related Codes

    CPT-81000-URINALYSIS-DIP-STICK-AND-MICROSCOPIC-EXAM

    CPT 81000: Manual Urinalysis with Microscopy

    CPT-81001-URINALYSIS-DIPSTICK-OR-TABLET-REAGENT

    CPT 81001: Urinalysis by Dipstick or Tablet Reagent

    CPT-81002-MANUAL-URINALYSIS-REAGENT-STRIP-TABLET

    CPT 81002: Manual Urine Dipstick Chemical Analysis

    CPT-81003-AUTOMATED-URINE-DIPSTICK-ANALYSIS

    CPT 81003: Automated Urinalysis Dipstick with Instrumented Reader

    CPT-81005-URINE-ANALYTE-QUALITATIVE-SEMIQUANTITATIVE

    CPT 81005: Urine Qualitative or Semiquantitative Analyte Test

    CPT-81007-URINE-BACTERIURIA-NONCULTURE-NONDIPSTICK-TEST

    CPT 81007: Nonculture, Nondipstick Urinalysis for Bacteriuria

    CPT-81015-MICROSCOPIC-URINALYSIS-LABORATORY-EXAMINATION

    CPT 81015: Microscopic Urinalysis, Sediment Examination

    CPT-81020-MICROSCOPIC-URINALYSIS-MULTIPLE-GLASS-COLLECTIONS

    CPT 81020: Microscopic Urine Examination of Multiple Specimens

    CPT-81025-URINE-PREGNANCY-TEST-VISUAL-READ

    CPT 81025: Urine Pregnancy Test, Analyst-Read Visual

    CPT-81050-TIMED-URINE-COLLECTION-VOLUME-MEASUREMENT

    CPT 81050: Timed Urine Volume Measurement

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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