CPT 80355: Gabapentin Detection in Nonblood Specimen

CPT code 80355 describes laboratory testing that measures the amount of or detects the presence of gabapentin in a patient specimen other than blood; the service type is toxicology/drug testing and the typical site of service is clinical laboratory or outpatient collection site where nonblood specimens (such as urine or oral fluid) are analyzed.

Customize your policy alerts

Sign up for cpt 80355 policy alerts

Get alerted when payer policies referencing 80355 are released or updated.

Monitor payer policy activity

Receive email alerts as soon as relevant payer policies are published or updated.

Explore openpayer tools

View all tools

CPT 80355: Gabapentin Detection in Nonblood Specimen

Customize your policy alerts

Sign up for cpt 80355 policy alerts

Get alerted when payer policies referencing 80355 are released or updated.

Monitor payer policy activity

Receive email alerts as soon as relevant payer policies are published or updated.

Clinical & Coding Specifications

Clinical Context

A typical patient scenario involves a clinician ordering a urine or other non-blood specimen drug test to confirm presence or concentration of gabapentin when there is clinical concern for adherence, diversion, overdose, or unexpected toxicity. Example: a 45-year-old patient with neuropathic pain on gabapentin presents with increased sedation and dizziness; the clinician obtains a urine specimen for targeted toxicology testing to detect gabapentin and assess recent use. The specimen is collected in the outpatient clinic or urgent care, labeled and sent to the laboratory. The laboratory analyst performs an assay (immunoassay screen with confirmatory testing such as chromatographic methods) on a non-blood matrix (commonly urine, saliva, or oral fluid) to detect and/or quantify gabapentin. Results are reported to the ordering provider and documented in the patient chart; positive or unexpected results may trigger follow-up such as medication reconciliation, patient counseling, or further confirmatory testing.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`80355`	Drug assay, gabapentin, other than blood; qualitative or quantitative	Primary code for detection/measurement of gabapentin in a non-blood specimen
`80307`	Drug confirmation assay, any number, each specimen (e.g., chromatography, mass spectrometry)	Used when a confirmatory chromatographic/mass spectrometry test is performed after initial screening
`81002`	Urinalysis, by dipstick or tablet reagent for bilirubin, glucose, hemoglobin, ketones, etc., non-automated, without microscopy	May be performed at point of care to assess specimen integrity or for concurrent clinical evaluation
`80320`	Drug screen, qualitative; multiple drug classes by any method	Often used for broader initial screening panels before or alongside targeted gabapentin testing
`G0480`	Drug testing: definitive drug test, definitive drug test (e.g., chromatography, mass spectrometry), any number of drug classes, each specimen	Used for definitive confirmatory testing in workflows requiring high-specificity confirmation

Related Modifiers

5 rows

Modifier	Description	When to Use
26	Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…	- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
90	Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…	- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
59	Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…	- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207K00000X	Allergy & Immunology Physician	An allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
208000000X	Pediatrics Physician	A pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
2084P0800X	Psychiatry Physician	A Psychiatrist specializes in the prevention, diagnosis, and treatment of mental disorders, emotional disorders, psychotic disorders, mood disorders, …
208M00000X	Hospitalist Physician	Hospitalists are physicians whose primary professional focus is the general medical care of hospitalized patients. Their activities include patient ca…
227900000X	Registered Respiratory Therapist	A Registered Respiratory Therapist (RRT) is an advanced therapist who has passed standardized written and clinical simulation examinations administere…
207XS0114X	Adult Reconstructive Orthopaedic Surgery Physician	Recognized by several state medical boards as a fellowship subspecialty program of orthopaedic surgery, adult reconstructive orthopaedic surgeons deal…
207LP4000X	Physician Nutrition Specialist (Anesthesiology)	A physician who specializes in the diagnosis and treatment of primary nutritional diseases (e.g., undernutrition, overnutrition, and genetic or acquir…
174M00000X	Veterinarian	A doctor of veterinary medicine, trained and authorized to practice veterinarian medicine and surgery.

CPT 80143: Acetaminophen Quantitative Assay

CPT-80145-ADALIMUMAB-LEVEL-ASSAY-THERAPEUTIC-DRUG-MONITORING

CPT 80145: Adalimumab Quantitative Drug Level Assay

CPT-80150-AMIKACIN-QUANTITATIVE-ASSAY-THERAPEUTIC-DRUG-MONITORING

CPT 80150: Amikacin Quantitative Serum Level

CPT-80151-AMIODARONE-QUANTITATIVE-SERUM-ASSAY

CPT 80151: Amiodarone Quantitative Drug Level Assay

CPT-80155-CAFFEINE-LEVEL-TESTING

CPT 80155: Caffeine Level Quantification

CPT-80156-CARBAMAZEPINE-TOTAL-LEVEL-LAB-ASSAY

CPT 80156: Carbamazepine Total Level (Serum)

CPT-80157-FREE-CARBAMAZEPINE-ASSAY

CPT 80157: Free Carbamazepine Quantitative Assay

CPT-80158-CYCLOSPORINE-QUANTITATIVE-ASSAY-LAB

CPT 80158: Cyclosporine Quantitation, Laboratory

CPT-80159-CLOZAPINE-LEVEL-ASSAY-THERAPEUTIC-DRUG-MONITORING

CPT 80159: Clozapine Level Measurement

CPT-80161-CARBAMAZEPINE-EPOXIDE-QUANTITATIVE-ASSAY

CPT 80161: Carbamazepine 10,11-Epoxide Level, Quantitative

Showing 1–10 of 87

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

Explore openpayer tools

View all tools

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`80355`	Drug assay, gabapentin, other than blood; qualitative or quantitative	Primary code for detection/measurement of gabapentin in a non-blood specimen
`80307`	Drug confirmation assay, any number, each specimen (e.g., chromatography, mass spectrometry)	Used when a confirmatory chromatographic/mass spectrometry test is performed after initial screening
`81002`	Urinalysis, by dipstick or tablet reagent for bilirubin, glucose, hemoglobin, ketones, etc., non-automated, without microscopy	May be performed at point of care to assess specimen integrity or for concurrent clinical evaluation
`80320`	Drug screen, qualitative; multiple drug classes by any method	Often used for broader initial screening panels before or alongside targeted gabapentin testing
`G0480`	Drug testing: definitive drug test, definitive drug test (e.g., chromatography, mass spectrometry), any number of drug classes, each specimen	Used for definitive confirmatory testing in workflows requiring high-specificity confirmation

Related Modifiers

5 rows

Modifier	Description	When to Use
26	Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…	- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
90	Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…	- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
59	Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…	- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207K00000X	Allergy & Immunology Physician	An allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
208000000X	Pediatrics Physician	A pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
2084P0800X	Psychiatry Physician	A Psychiatrist specializes in the prevention, diagnosis, and treatment of mental disorders, emotional disorders, psychotic disorders, mood disorders, …
208M00000X	Hospitalist Physician	Hospitalists are physicians whose primary professional focus is the general medical care of hospitalized patients. Their activities include patient ca…
227900000X	Registered Respiratory Therapist	A Registered Respiratory Therapist (RRT) is an advanced therapist who has passed standardized written and clinical simulation examinations administere…
207XS0114X	Adult Reconstructive Orthopaedic Surgery Physician	Recognized by several state medical boards as a fellowship subspecialty program of orthopaedic surgery, adult reconstructive orthopaedic surgeons deal…
207LP4000X	Physician Nutrition Specialist (Anesthesiology)	A physician who specializes in the diagnosis and treatment of primary nutritional diseases (e.g., undernutrition, overnutrition, and genetic or acquir…
174M00000X	Veterinarian	A doctor of veterinary medicine, trained and authorized to practice veterinarian medicine and surgery.

CPT 80143: Acetaminophen Quantitative Assay

CPT-80145-ADALIMUMAB-LEVEL-ASSAY-THERAPEUTIC-DRUG-MONITORING

CPT 80145: Adalimumab Quantitative Drug Level Assay

CPT-80150-AMIKACIN-QUANTITATIVE-ASSAY-THERAPEUTIC-DRUG-MONITORING

CPT 80150: Amikacin Quantitative Serum Level

CPT-80151-AMIODARONE-QUANTITATIVE-SERUM-ASSAY

CPT 80151: Amiodarone Quantitative Drug Level Assay

CPT-80155-CAFFEINE-LEVEL-TESTING

CPT 80155: Caffeine Level Quantification

CPT-80156-CARBAMAZEPINE-TOTAL-LEVEL-LAB-ASSAY

CPT 80156: Carbamazepine Total Level (Serum)

CPT-80157-FREE-CARBAMAZEPINE-ASSAY

CPT 80157: Free Carbamazepine Quantitative Assay

CPT-80158-CYCLOSPORINE-QUANTITATIVE-ASSAY-LAB

CPT 80158: Cyclosporine Quantitation, Laboratory

CPT-80159-CLOZAPINE-LEVEL-ASSAY-THERAPEUTIC-DRUG-MONITORING

CPT 80159: Clozapine Level Measurement

CPT-80161-CARBAMAZEPINE-EPOXIDE-QUANTITATIVE-ASSAY

CPT 80161: Carbamazepine 10,11-Epoxide Level, Quantitative

Showing 1–10 of 87

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

OpenPayer

CPT 80355: Gabapentin Detection in Nonblood Specimen

Sign up for cpt 80355 policy alerts

OpenPayer

CPT 80355: Gabapentin Detection in Nonblood Specimen

Sign up for cpt 80355 policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

References

CPT 80355: Gabapentin Detection in Nonblood Specimen

Sign up for cpt 80355 policy alerts

CPT 80355: Gabapentin Detection in Nonblood Specimen

Sign up for cpt 80355 policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

What does CPT 80355 represent and when is it typically used?

Which billing modifiers are associated with 80355 and when should they be applied?

What other CPT codes are commonly billed with or related to 80355?

In what clinical scenarios is non-blood gabapentin testing (80355) ordered?

Which payers are referenced for coverage of 80355 and where can I find reimbursement details?

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

What does CPT 80355 represent and when is it typically used?

Which billing modifiers are associated with 80355 and when should they be applied?

What other CPT codes are commonly billed with or related to 80355?

In what clinical scenarios is non-blood gabapentin testing (80355) ordered?

Which payers are referenced for coverage of 80355 and where can I find reimbursement details?

References