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    v1.0.30
    OpenPayerBilling CodesTherapeutic Drug AssaysCPT cpt-80150-amikacin-quantitative-assay-therapeutic-drug-monitoring
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    CPT 80150: Amikacin Quantitative Serum Level

    CPT code 80150 describes a laboratory therapeutic drug monitoring procedure in which a lab analyst performs the technical test to quantitate the amount of amikacin in a patient specimen; the service type is quantitative drug assay/therapeutic drug monitoring, and the typical site of service is a clinical laboratory or hospital laboratory where specimens (usually serum) are analyzed for drug concentration to guide clinical management.

    For related coverage guidance, see recent payer policy updates: Long-Acting Injectable Antiretroviral Agents for HIV, B-Hemolytic Streptococcus Testing, Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance Assays.

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    Clinical & Coding Specifications

    Clinical Context

    A 58-year-old hospitalized patient with a history of severe gram-negative sepsis is receiving intravenous amikacin for multi-drug resistant infection. The patient is critically ill with fluctuating renal function; the infectious disease team orders therapeutic drug monitoring (TDM) to quantitate serum amikacin levels to ensure efficacy and minimize nephrotoxicity and ototoxicity. A nursing phlebotomist draws timed trough and/or peak serum specimens and sends them to the hospital central laboratory. The lab analyst performs the technical assay corresponding to 80150 to measure the concentration of amikacin in the specimen and generates a quantitative result reported to the ordering clinician. Results are used by the clinician to adjust dosing and schedule repeat levels as needed. Typical site of service is an inpatient hospital laboratory or an outpatient hospital-based clinic/lab with the technical component performed by trained clinical laboratory scientists.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    36415Collection of venous blood by venipunctureSpecimen collection for amikacin level measurement; typically performed immediately prior to dosing (trough) or at specified timepoints (peak).
    81025Urinalysis, non-automated, without microscopySupportive monitoring for renal function; often ordered alongside amikacin levels to assess nephrotoxicity risk.
    80053Comprehensive metabolic panel (CMP)Provides serum creatinine and electrolyte data used to interpret amikacin pharmacokinetics and adjust dosing.
    84156Creatinine; urine or serum, quantitative, includes calculation of creatinine clearance when performedRenal function assessment used to determine dosing and interval adjustments for amikacin.
    80399Unlisted chemistry procedureUsed when a lab performs a bespoke or novel quantitative assay platform for amikacin not represented by a standard code.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207K00000X
    207L00000X
    2080P0006X
    207RH0000X
    208000000X
    222Q00000X
    246Q00000X
    261QR0405X

    Related ICD-10-CM Codes

    29 rows

    ICD-10-CM CodeDescription
    A20.2Pneumonic plague
    A32.7Listerial sepsis
    A41.51Sepsis due to Escherichia coli [E. coli]
    A41.52Sepsis due to Pseudomonas
    A41.9Sepsis, unspecified organism
    A49.1Streptococcal infection, unspecified site
    A54.81Gonococcal meningitis
    A56.01Chlamydial cystitis and urethritis
    B96.5Pseudomonas (aeruginosa) (mallei) (pseudomallei) as the cause of diseases classified elsewhere
    G00.9Bacterial meningitis, unspecified

    Showing 1–10 of 29

    Related Payer Policy Updates

    Specialty: Infectious Disease1 / 3

    10 rows

    PolicyPayerEffective Date
    Long-Acting Injectable Antiretroviral Agents for HIVColorado Rocky Mountain Health Plans2026-10-01
    B-Hemolytic Streptococcus TestingOscar Health2026-10-01
    Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance AssaysOscar Health2026-10-01
    Hepatitis Testing (A, B, C, D) Coverage CriteriaOscar Health2026-10-01
    Lyme Disease Testing Coverage CriteriaOscar Health2026-10-01
    Pathogen Panel TestingOscar Health2026-10-01
    Diagnostic Testing of Common Sexually Transmitted InfectionsOscar Health2026-10-01
    Coronavirus Testing in the Outpatient SettingOscar Health2026-10-01
    Testing for Vector-Borne InfectionsOscar Health2026-10-01
    Testing for Diagnosis of Active or Latent TuberculosisOscar Health2026-10-01

    Related Codes

    CPT-80143-ACETAMINOPHEN-QUANTITATIVE-SERUM-ASSAY

    CPT 80143: Acetaminophen Quantitative Assay

    CPT-80145-ADALIMUMAB-LEVEL-ASSAY-THERAPEUTIC-DRUG-MONITORING

    CPT 80145: Adalimumab Quantitative Drug Level Assay

    CPT-80151-AMIODARONE-QUANTITATIVE-SERUM-ASSAY

    CPT 80151: Amiodarone Quantitative Drug Level Assay

    CPT-80155-CAFFEINE-LEVEL-TESTING

    CPT 80155: Caffeine Level Quantification

    CPT-80156-CARBAMAZEPINE-TOTAL-LEVEL-LAB-ASSAY

    CPT 80156: Carbamazepine Total Level (Serum)

    CPT-80157-FREE-CARBAMAZEPINE-ASSAY

    CPT 80157: Free Carbamazepine Quantitative Assay

    CPT-80158-CYCLOSPORINE-QUANTITATIVE-ASSAY-LAB

    CPT 80158: Cyclosporine Quantitation, Laboratory

    CPT-80159-CLOZAPINE-LEVEL-ASSAY-THERAPEUTIC-DRUG-MONITORING

    CPT 80159: Clozapine Level Measurement

    CPT-80161-CARBAMAZEPINE-EPOXIDE-QUANTITATIVE-ASSAY

    CPT 80161: Carbamazepine 10,11-Epoxide Level, Quantitative

    CPT-80162-DIGOXIN-TOTAL-THERAPEUTIC-DRUG-MONITORING

    CPT 80162: Total Digoxin Level in Serum

    Showing 1–10 of 87

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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