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    v1.0.28
    OpenPayerBilling CodesTherapeutic Drug AssaysCPT cpt-80336-tricyclic-and-cyclic-antidepressant-testing
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    CPT 80336: Tricyclic and Other Cyclic Antidepressant Panel

    CPT code 80336 describes a laboratory test that measures or detects the presence of three to five tricyclic and other cyclic antidepressant medications in a patient specimen, classified as a toxicology/drug assay panel; the service is clinical laboratory testing for therapeutic drug monitoring or toxicology screening and the typical site of service is a clinical laboratory or hospital laboratory performing specimen analysis.

    For related coverage guidance, see recent payer policy updates: Epithelial Cell Cytology in Breast Cancer Risk Assessment, Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only), Antibody-Drug Conjugates.

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    Clinical & Coding Specifications

    Clinical Context

    A 35-year-old outpatient with a history of major depressive disorder presents for therapeutic drug monitoring after a recent change in antidepressant regimen. The clinician suspects either subtherapeutic dosing, nonadherence, or potential polypharmacy with older tricyclic or cyclic antidepressants. A blood specimen is collected in the clinic or outpatient laboratory and sent to the reference lab. The laboratory analyst performs a qualitative and/or quantitative panel to detect and measure three to five tricyclic and other cyclic antidepressants using validated methods (e.g., immunoassay, GC-MS, or LC-MS/MS). Results are reported to the ordering clinician, who uses concentrations to assess adherence, toxicity risk, drug interactions, or to guide dose adjustments. Typical sites of service include hospital outpatient laboratories, independent clinical reference laboratories, and ambulatory clinics with specimen collection and reporting workflows.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    80336Tricyclic and other cyclic antidepressant panel, 3–5 analytes; qualitative or quantitativeThis is the primary code for detecting/measuring three to five tricyclic and cyclic antidepressants in a patient specimen.
    80307Drug assay, presumptive, any number of drug classes; e.g., immunoassay(s)Often performed as an initial presumptive screen before confirmatory testing with 80336.
    80305Drug assay, quantitative, multiple drugs, presumptive or confirmatory methodsMay be used for quantitative measurement of individual antidepressant levels when a broader or different panel is required.
    80311Drug confirmation, definitive; e.g., GC-MS, LC-MS; single or multiple analytesUsed to confirm positive or ambiguous 80336 results with definitive methods and specific analyte quantitation.
    G0480Toxicology testing (clinical laboratory) — not specific to antidepressantsMay be used for specialized or bundled toxicology services depending on payer policy and lab reporting arrangements.

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207RH0000XHematology (Internal Medicine) PhysicianAn internist with additional training who specializes in diseases of the blood, spleen and lymph. This specialist treats conditions such as anemia, cl…
    207K00000XAllergy & Immunology PhysicianAn allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
    2084P0800XPsychiatry PhysicianA Psychiatrist specializes in the prevention, diagnosis, and treatment of mental disorders, emotional disorders, psychotic disorders, mood disorders, …
    363L00000XNurse Practitioner(1) A registered nurse provider with a graduate degree in nursing prepared for advanced practice involving independent and interdependent decision mak…
    103TB0200XCognitive & Behavioral PsychologistA psychologist who reflects an experimental-clinical approach distinguished by use of principles of human learning and development and theories of cog…
    261QM1000XMigrant Health Clinic/CenterAmbulatory Health Care Facilities · Clinic/Center
    282E00000XLong Term Care HospitalLong-term care hospitals (LTCHs) furnish extended medical and rehabilitative care to individuals who are clinically complex and have multiple acute or…
    152WX0102XOccupational Vision OptometristOptometrists who work in Occupational Vision, the branch of environmental optometry, consider all aspects of the relationship between work and vision,…

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 2

    4 rows

    PolicyPayerEffective Date
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only)UnitedHealthcare2026-08-01
    Antibody-Drug ConjugatesPremera Bluecross2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only)UnitedHealthcare2026-08-01

    Related Codes

    CPT-80143-ACETAMINOPHEN-QUANTITATIVE-SERUM-ASSAY

    CPT 80143: Acetaminophen Quantitative Assay

    CPT-80145-ADALIMUMAB-LEVEL-ASSAY-THERAPEUTIC-DRUG-MONITORING

    CPT 80145: Adalimumab Quantitative Drug Level Assay

    CPT-80150-AMIKACIN-QUANTITATIVE-ASSAY-THERAPEUTIC-DRUG-MONITORING

    CPT 80150: Amikacin Quantitative Serum Level

    CPT-80151-AMIODARONE-QUANTITATIVE-SERUM-ASSAY

    CPT 80151: Amiodarone Quantitative Drug Level Assay

    CPT-80155-CAFFEINE-LEVEL-TESTING

    CPT 80155: Caffeine Level Quantification

    CPT-80156-CARBAMAZEPINE-TOTAL-LEVEL-LAB-ASSAY

    CPT 80156: Carbamazepine Total Level (Serum)

    CPT-80157-FREE-CARBAMAZEPINE-ASSAY

    CPT 80157: Free Carbamazepine Quantitative Assay

    CPT-80158-CYCLOSPORINE-QUANTITATIVE-ASSAY-LAB

    CPT 80158: Cyclosporine Quantitation, Laboratory

    CPT-80159-CLOZAPINE-LEVEL-ASSAY-THERAPEUTIC-DRUG-MONITORING

    CPT 80159: Clozapine Level Measurement

    CPT-80161-CARBAMAZEPINE-EPOXIDE-QUANTITATIVE-ASSAY

    CPT 80161: Carbamazepine 10,11-Epoxide Level, Quantitative

    Showing 1–10 of 87

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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