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    v1.0.30
    OpenPayerBilling CodesTherapeutic Drug AssaysCPT cpt-80341-multiple-antiepileptic-drug-panel-7-plus
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    CPT 80341: Multi-Drug Antiepileptic Assay (7+ Drugs)

    CPT code 80341 describes a laboratory test that measures or detects the presence of seven or more antiepileptic (anticonvulsant/antiseizure) medications in a patient specimen; the service is a multi-drug antiepileptic assay typically performed by a clinical laboratory using specialized analytical methods and is usually provided in an outpatient or reference laboratory setting.

    For related coverage guidance, see recent payer policy updates: Hematology - Adzynma, Tumor Treating Fields for Pancreatic Cancer, Axicabtagene ciloleucel (Yescarta®) coverage.

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    Clinical & Coding Specifications

    Clinical Context

    A 28-year-old patient with refractory generalized epilepsy presents for therapeutic drug monitoring and medication compliance assessment after recent seizure clusters. The neurology provider orders a comprehensive antiepileptic drug panel to detect and quantify multiple anticonvulsant agents because the patient is taking several older and newer antiseizure medications and the specific drugs are not covered by single-drug assays. The specimen (serum or plasma) is collected in an outpatient phlebotomy clinic or hospital laboratory; the sample is transported to a reference laboratory with mass spectrometry capability. The laboratory analyst performs a multi-analyte qualitative/quantitative assay that measures the presence and amounts of seven or more antiepileptic medications to guide medication adjustments, identify drug interactions, confirm adherence, and investigate toxicity. Typical workflow steps include order entry by the neurologist, specimen collection by nursing or phlebotomy staff at an ambulatory clinic or inpatient unit, courier transport to the clinical lab, analytical testing by the laboratory using validated instrumentation (for example, LC-MS/MS), result verification by a lab director, and reporting to the ordering clinician for clinical interpretation and medication management decisions.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    80341Drug assay, qualitative or quantitative, antiepileptic drugs, seven or more drugsPrimary code for a multi-analyte antiepileptic panel measuring seven or more anticonvulsant medications in a patient specimen.
    80307Drug assay, qualitative or quantitative, single or multiple drug class analyte(s); second through third drug(s)May be used when fewer analytes are tested (single or limited drug class assays) before escalating to a comprehensive panel.
    80305Drug assay, qualitative or quantitative, presumptive, any number of drug classes; 1-4 drug classesCommonly used for initial screening panels when only limited classes are required prior to confirmatory testing with a targeted panel.
    82310Assay of drug or metabolite, therapeutic drug monitoring (example: carbamazepine)Individual therapeutic drug assays may be ordered alongside multi-panel testing for precise quantitation of a specific antiepileptic.
    80350Confirmation of drug presence by a definitive method (e.g., GC/MS or LC-MS/MS)Used when definitive identification/confirmation and quantitation of specific antiepileptics are required following initial screening or panel results.

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RH0000X
    2080P0207X
    311ZA0620X
    207ZC0008X
    207PS0010X
    332900000X
    247ZC0005X
    246ZB0500X

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 2

    10 rows

    PolicyPayerEffective Date
    Hematology - AdzynmaCigna2026-10-15
    Tumor Treating Fields for Pancreatic Cancerselect_health2026-10-01
    Axicabtagene ciloleucel (Yescarta®) coverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Kentucky Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Kansas Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Idaho Only)UnitedHealthcare2026-10-01
    Brexucabtagene autoleucel (Tecartus) CoverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Pennsylvania Only)UnitedHealthcare2026-10-01
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Factor VIII ProductsCigna2026-09-15

    Related Codes

    CPT-80143-ACETAMINOPHEN-QUANTITATIVE-SERUM-ASSAY

    CPT 80143: Acetaminophen Quantitative Assay

    CPT-80145-ADALIMUMAB-LEVEL-ASSAY-THERAPEUTIC-DRUG-MONITORING

    CPT 80145: Adalimumab Quantitative Drug Level Assay

    CPT-80150-AMIKACIN-QUANTITATIVE-ASSAY-THERAPEUTIC-DRUG-MONITORING

    CPT 80150: Amikacin Quantitative Serum Level

    CPT-80151-AMIODARONE-QUANTITATIVE-SERUM-ASSAY

    CPT 80151: Amiodarone Quantitative Drug Level Assay

    CPT-80155-CAFFEINE-LEVEL-TESTING

    CPT 80155: Caffeine Level Quantification

    CPT-80156-CARBAMAZEPINE-TOTAL-LEVEL-LAB-ASSAY

    CPT 80156: Carbamazepine Total Level (Serum)

    CPT-80157-FREE-CARBAMAZEPINE-ASSAY

    CPT 80157: Free Carbamazepine Quantitative Assay

    CPT-80158-CYCLOSPORINE-QUANTITATIVE-ASSAY-LAB

    CPT 80158: Cyclosporine Quantitation, Laboratory

    CPT-80159-CLOZAPINE-LEVEL-ASSAY-THERAPEUTIC-DRUG-MONITORING

    CPT 80159: Clozapine Level Measurement

    CPT-80161-CARBAMAZEPINE-EPOXIDE-QUANTITATIVE-ASSAY

    CPT 80161: Carbamazepine 10,11-Epoxide Level, Quantitative

    Showing 1–10 of 87

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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