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    v1.0.30
    OpenPayerBilling CodesTherapeutic Drug AssaysCPT cpt-80342-antipsychotic-drug-testing-1-to-3-drugs
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    CPT 80342: Antipsychotic Drug Detection or Measurement (1–3 Drugs)

    CPT code 80342 describes a laboratory test that measures the amount of or detects the presence of one to three antipsychotic medications in a patient specimen; this is a qualitative or quantitative antipsychotic drug test typically performed as a clinical toxicology service in hospital, outpatient laboratory, or clinical diagnostic settings to support therapeutic monitoring, adherence assessment, or evaluation of suspected toxicity or overdose.

    For related coverage guidance, see recent payer policy updates: Hematology - Adzynma, Tumor Treating Fields for Pancreatic Cancer, Axicabtagene ciloleucel (Yescarta®) coverage.

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    Clinical & Coding Specifications

    Clinical Context

    A 34-year-old adult male with a history of schizophrenia presents to an outpatient behavioral health clinic for routine monitoring after a medication change. The treating psychiatrist orders a urine or serum drug test to measure one to three antipsychotic agents to confirm adherence, assess for polypharmacy, and evaluate therapeutic exposure. The specimen is collected in the clinic or sent to a reference laboratory. The laboratory analyst performs targeted qualitative and/or quantitative analysis for antipsychotic medications not otherwise specified by other CPT codes, documents results in the laboratory information system, and returns results to the ordering provider. Typical sites of service include outpatient behavioral health clinics, hospital outpatient laboratories, emergency departments when antipsychotic exposure is clinically relevant, and independent clinical laboratories. The clinical workflow includes specimen collection, chain-of-custody if required, specimen accessioning, analytic testing (e.g., immunoassay screening followed by confirmatory mass spectrometry when indicated), result verification by a qualified laboratory professional, and reporting to the ordering psychiatrist or treating team for medication management decisions.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    80343Antipsychotics, confirmation and quantification, each specimen — confirmatory testing for antipsychotics when a screening test is positive or when quantitative levels are required.Often performed after an initial 80342 screening to provide confirmatory qualitative/quantitative results or to measure additional analytes.
    80361Amphetamines; confirmation and quantificationCommonly ordered concurrently in substance use evaluation panels when broader toxicology screening is needed.
    80307Drug test(s), presumptive, any number of drug classes; any number of devicesMay be used as an initial point-of-care screen before sending a specimen for the more specific antipsychotic panel represented by 80342.
    80104Drug confirmation, presumptive positive, confirmation by chromatography (e.g., GC/MS, LC/MS/MS), each drug classUsed when mass spectrometry confirmation of antipsychotic or other drug levels is required following 80342 screening.
    81025Urinalysis, automated with microscopyPerformed as part of specimen integrity and to evaluate urine characteristics prior to toxicology testing.

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    2084P0800X
    208000000X
    246R00000X
    1835E0208X
    207ZP0101X
    3336C0003X
    207Q00000X
    315P00000X

    Related ICD-10-CM Codes

    26 rows

    ICD-10-CM CodeDescription
    F06.8Other specified mental disorders due to known physiological condition
    F07.0Personality change due to known physiological condition
    F20.9Schizophrenia, unspecified
    F21Schizotypal disorder
    F25.0Schizoaffective disorder, bipolar type
    F29Unspecified psychosis not due to a substance or known physiological condition
    F30.2Manic episode, severe with psychotic symptoms
    F32.9Major depressive disorder, single episode, unspecified
    F33.1Major depressive disorder, recurrent, moderate
    F41.1Generalized anxiety disorder

    Showing 1–10 of 26

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 2

    10 rows

    PolicyPayerEffective Date
    Hematology - AdzynmaCigna2026-10-15
    Tumor Treating Fields for Pancreatic Cancerselect_health2026-10-01
    Axicabtagene ciloleucel (Yescarta®) coverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Kentucky Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Kansas Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Idaho Only)UnitedHealthcare2026-10-01
    Brexucabtagene autoleucel (Tecartus) CoverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Pennsylvania Only)UnitedHealthcare2026-10-01
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Factor VIII ProductsCigna2026-09-15

    Related Codes

    CPT-80143-ACETAMINOPHEN-QUANTITATIVE-SERUM-ASSAY

    CPT 80143: Acetaminophen Quantitative Assay

    CPT-80145-ADALIMUMAB-LEVEL-ASSAY-THERAPEUTIC-DRUG-MONITORING

    CPT 80145: Adalimumab Quantitative Drug Level Assay

    CPT-80150-AMIKACIN-QUANTITATIVE-ASSAY-THERAPEUTIC-DRUG-MONITORING

    CPT 80150: Amikacin Quantitative Serum Level

    CPT-80151-AMIODARONE-QUANTITATIVE-SERUM-ASSAY

    CPT 80151: Amiodarone Quantitative Drug Level Assay

    CPT-80155-CAFFEINE-LEVEL-TESTING

    CPT 80155: Caffeine Level Quantification

    CPT-80156-CARBAMAZEPINE-TOTAL-LEVEL-LAB-ASSAY

    CPT 80156: Carbamazepine Total Level (Serum)

    CPT-80157-FREE-CARBAMAZEPINE-ASSAY

    CPT 80157: Free Carbamazepine Quantitative Assay

    CPT-80158-CYCLOSPORINE-QUANTITATIVE-ASSAY-LAB

    CPT 80158: Cyclosporine Quantitation, Laboratory

    CPT-80159-CLOZAPINE-LEVEL-ASSAY-THERAPEUTIC-DRUG-MONITORING

    CPT 80159: Clozapine Level Measurement

    CPT-80161-CARBAMAZEPINE-EPOXIDE-QUANTITATIVE-ASSAY

    CPT 80161: Carbamazepine 10,11-Epoxide Level, Quantitative

    Showing 1–10 of 87

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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