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    v1.0.28
    OpenPayerBilling CodesTherapeutic Drug AssaysCPT cpt-80343-antipsychotics-panel-4-to-6-drugs
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    CPT 80343: Antipsychotic Panel, Detection/Quantification of 4–6 Drugs

    CPT code 80343 describes a laboratory test that detects or measures the presence of four to six antipsychotic medications in a patient specimen; the service is a toxicology/mass spectrometry antipsychotic panel typically performed as a clinical laboratory test in an outpatient laboratory or hospital clinical lab to support monitoring of psychiatric medication use and adherence.

    For related coverage guidance, see recent payer policy updates: Epithelial Cell Cytology in Breast Cancer Risk Assessment, Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only), Antibody-Drug Conjugates.

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    Clinical & Coding Specifications

    Clinical Context

    A 34-year-old patient with a history of schizophrenia presents to an outpatient psychiatric clinic for medication monitoring after a recent dose adjustment. The clinician orders laboratory testing to detect and quantify multiple antipsychotic agents and potential metabolites in the patient’s blood or urine to confirm adherence, evaluate polypharmacy, or assess for toxic levels after symptom changes. The specimen is collected in the clinic or at an outpatient laboratory, labeled, and sent to a clinical toxicology laboratory. A laboratory analyst performs a multi-analyte immunoassay or chromatographic-mass spectrometry panel that measures or detects four to six antipsychotic drugs not otherwise specified by single-analyte CPT codes. Results are reported to the ordering psychiatrist, who integrates findings into medication management and documents the test order, specimen source, and clinical indication (e.g., medication adherence, therapeutic monitoring, suspected overdose) in the medical record.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    80307Drug test, presumptive, any number of drug classes by instrumented chemistry analyzers, qualitativeOften used as an initial screening test prior to or alongside quantitative antipsychotic panels to detect classes of drugs.
    80305Drug test, presumptive, e.g., immunoassay, any number of drug classes, qualitative; each procedureUsed for point-of-care screening that may precede confirmatory multi-analyte antipsychotic testing.
    80336Drug confirmation, any number of drug classes by GC-MS or LC-MS/MS, qualitative or quantitative, each specimenPerformed to confirm and precisely identify antipsychotic drugs and metabolites detected on a preliminary panel; may follow 80343 for definitive confirmation.
    82542Drug assay, ethyl alcohol; quantitativeRelevant when alcohol levels are assessed concurrently in cases of suspected intoxication.
    81002Urinalysis, non-automated, without microscopy; non-automated, without reagent stripCollected specimen source documentation; basic urinalysis may be performed along with drug testing for clinical context.
    80343Drug detection/measurement, 4–6 antipsychotics, not specified elsewhereThe primary procedure described; used when a panel targets multiple antipsychotic agents for detection or quantification.

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    2084P0800XPsychiatry PhysicianA Psychiatrist specializes in the prevention, diagnosis, and treatment of mental disorders, emotional disorders, psychotic disorders, mood disorders, …
    207RC0000XCardiovascular Disease PhysicianAn internist who specializes in diseases of the heart and blood vessels and manages complex cardiac conditions such as heart attacks and life-threaten…
    363L00000XNurse Practitioner(1) A registered nurse provider with a graduate degree in nursing prepared for advanced practice involving independent and interdependent decision mak…
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    208M00000XHospitalist PhysicianHospitalists are physicians whose primary professional focus is the general medical care of hospitalized patients. Their activities include patient ca…
    225CA2400XAssistive Technology Practitioner Rehabilitation CounselorRespiratory, Developmental, Rehabilitative and Restorative Service Providers · Rehabilitation Counselor
    1744G0900XGraphics DesignerOther Service Providers · Specialist
    111NR0400XRehabilitation ChiropractorRehabilitation is the discipline focused on restoring a patient's functional abilities to pre-injury or pre-disease status. Functional abilities are d…

    Related ICD-10-CM Codes

    30 rows

    ICD-10-CM CodeDescription
    F10.20Alcohol dependence, uncomplicated
    F11.20Opioid dependence, uncomplicated
    F12.20Cannabis dependence, uncomplicated
    F19.20Other psychoactive substance dependence, uncomplicated
    F20.0Paranoid schizophrenia
    F20.9Schizophrenia, unspecified
    F25.0Schizoaffective disorder, bipolar type
    F25.1Schizoaffective disorder, depressive type
    F29Unspecified psychosis not due to a substance or known physiological condition
    F31.4Bipolar disorder, current episode depressed, severe, without psychotic features

    Showing 1–10 of 30

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 2

    4 rows

    PolicyPayerEffective Date
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only)UnitedHealthcare2026-08-01
    Antibody-Drug ConjugatesPremera Bluecross2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only)UnitedHealthcare2026-08-01

    Related Codes

    CPT-80143-ACETAMINOPHEN-QUANTITATIVE-SERUM-ASSAY

    CPT 80143: Acetaminophen Quantitative Assay

    CPT-80145-ADALIMUMAB-LEVEL-ASSAY-THERAPEUTIC-DRUG-MONITORING

    CPT 80145: Adalimumab Quantitative Drug Level Assay

    CPT-80150-AMIKACIN-QUANTITATIVE-ASSAY-THERAPEUTIC-DRUG-MONITORING

    CPT 80150: Amikacin Quantitative Serum Level

    CPT-80151-AMIODARONE-QUANTITATIVE-SERUM-ASSAY

    CPT 80151: Amiodarone Quantitative Drug Level Assay

    CPT-80155-CAFFEINE-LEVEL-TESTING

    CPT 80155: Caffeine Level Quantification

    CPT-80156-CARBAMAZEPINE-TOTAL-LEVEL-LAB-ASSAY

    CPT 80156: Carbamazepine Total Level (Serum)

    CPT-80157-FREE-CARBAMAZEPINE-ASSAY

    CPT 80157: Free Carbamazepine Quantitative Assay

    CPT-80158-CYCLOSPORINE-QUANTITATIVE-ASSAY-LAB

    CPT 80158: Cyclosporine Quantitation, Laboratory

    CPT-80159-CLOZAPINE-LEVEL-ASSAY-THERAPEUTIC-DRUG-MONITORING

    CPT 80159: Clozapine Level Measurement

    CPT-80161-CARBAMAZEPINE-EPOXIDE-QUANTITATIVE-ASSAY

    CPT 80161: Carbamazepine 10,11-Epoxide Level, Quantitative

    Showing 1–10 of 87

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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