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    v1.0.30
    OpenPayerBilling CodesTherapeutic Drug AssaysCPT cpt-80155-caffeine-level-testing
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    CPT 80155: Caffeine Level Quantification

    CPT code 80155 describes a laboratory test that measures the level of caffeine in a patient’s specimen; the service is a toxicology/drug assay typically performed in a clinical laboratory or hospital laboratory on serum, plasma, or urine specimens to quantify caffeine concentration for diagnostic, toxicologic, or monitoring purposes.

    For related coverage guidance, see recent payer policy updates: Long-Acting Injectable Antiretroviral Agents for HIV, B-Hemolytic Streptococcus Testing, Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance Assays.

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    Clinical & Coding Specifications

    Clinical Context

    A 28-year-old patient presents to an emergency department after a motor vehicle collision with unexplained agitation and a history suggesting possible stimulant or toxic exposure. The treating clinician orders a serum caffeine level to determine whether high caffeine ingestion contributed to tachycardia, tremor, or arrhythmia. A phlebotomy technician collects a blood specimen and sends it to the hospital clinical laboratory. The laboratory performs CPT 80155 testing using immunoassay or mass spectrometry to quantify caffeine concentration. Results are reported to the ordering provider and documented in the electronic medical record; critical or markedly elevated results prompt immediate clinical notification for potential treatment of caffeine toxicity. Typical sites of service include hospital inpatient and outpatient laboratories, emergency departments, and independent diagnostic testing facilities (IDTFs).

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    36415Collection of venous blood by venipunctureSpecimen collection commonly performed prior to CPT 80155 testing
    80305Drug test(s), presumptive, any number of drug classes by instrumented chemistry analyzers; each drug classInitial screening tests for multiple drugs/toxins that may accompany caffeine testing in toxicology evaluation
    80307Drug confirmation, quantitative, presumptive positive, each drug class by mass spectrometry (e.g., GC/MS, LC/MS/MS)Confirmatory testing for specific analytes; laboratories may use similar confirmatory methods for precise caffeine quantification
    80311Drug test confirmation, quantitative, by mass spectrometry for multiple drugsUsed when confirmatory testing for multiple substances is ordered alongside caffeine level
    80053Comprehensive metabolic panel (CMP)Routine chemistry panel ordered concurrently to assess metabolic consequences of toxicity
    99000Handling and/or conveyance of specimen to a laboratory — non-covered by many payorsOccasionally used by some facilities for special handling logistics (verify payor policy)

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207K00000X
    207L00000X
    208000000X
    207R00000X
    2083P0901X
    2084B0040X
    261QB0400X
    332BP3500X

    Related ICD-10-CM Codes

    27 rows

    ICD-10-CM CodeDescription
    F10.129Alcohol abuse with intoxication, unspecified
    F15.10Other stimulant abuse, uncomplicated
    F15.20Other stimulant dependence, uncomplicated
    F15.21Other stimulant dependence, in remission
    F32.9Major depressive disorder, single episode, unspecified
    F41.0Panic disorder [episodic paroxysmal anxiety]
    F41.9Anxiety disorder, unspecified
    F90.9Attention-deficit hyperactivity disorder, unspecified type
    G43.909Migraine, unspecified, not intractable, without status migrainosus
    G47.00Insomnia, unspecified

    Showing 1–10 of 27

    Related Payer Policy Updates

    Specialty: Infectious Disease1 / 3

    10 rows

    PolicyPayerEffective Date
    Long-Acting Injectable Antiretroviral Agents for HIVColorado Rocky Mountain Health Plans2026-10-01
    B-Hemolytic Streptococcus TestingOscar Health2026-10-01
    Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance AssaysOscar Health2026-10-01
    Hepatitis Testing (A, B, C, D) Coverage CriteriaOscar Health2026-10-01
    Lyme Disease Testing Coverage CriteriaOscar Health2026-10-01
    Pathogen Panel TestingOscar Health2026-10-01
    Diagnostic Testing of Common Sexually Transmitted InfectionsOscar Health2026-10-01
    Coronavirus Testing in the Outpatient SettingOscar Health2026-10-01
    Testing for Vector-Borne InfectionsOscar Health2026-10-01
    Testing for Diagnosis of Active or Latent TuberculosisOscar Health2026-10-01

    Related Codes

    CPT-80143-ACETAMINOPHEN-QUANTITATIVE-SERUM-ASSAY

    CPT 80143: Acetaminophen Quantitative Assay

    CPT-80145-ADALIMUMAB-LEVEL-ASSAY-THERAPEUTIC-DRUG-MONITORING

    CPT 80145: Adalimumab Quantitative Drug Level Assay

    CPT-80150-AMIKACIN-QUANTITATIVE-ASSAY-THERAPEUTIC-DRUG-MONITORING

    CPT 80150: Amikacin Quantitative Serum Level

    CPT-80151-AMIODARONE-QUANTITATIVE-SERUM-ASSAY

    CPT 80151: Amiodarone Quantitative Drug Level Assay

    CPT-80156-CARBAMAZEPINE-TOTAL-LEVEL-LAB-ASSAY

    CPT 80156: Carbamazepine Total Level (Serum)

    CPT-80157-FREE-CARBAMAZEPINE-ASSAY

    CPT 80157: Free Carbamazepine Quantitative Assay

    CPT-80158-CYCLOSPORINE-QUANTITATIVE-ASSAY-LAB

    CPT 80158: Cyclosporine Quantitation, Laboratory

    CPT-80159-CLOZAPINE-LEVEL-ASSAY-THERAPEUTIC-DRUG-MONITORING

    CPT 80159: Clozapine Level Measurement

    CPT-80161-CARBAMAZEPINE-EPOXIDE-QUANTITATIVE-ASSAY

    CPT 80161: Carbamazepine 10,11-Epoxide Level, Quantitative

    CPT-80162-DIGOXIN-TOTAL-THERAPEUTIC-DRUG-MONITORING

    CPT 80162: Total Digoxin Level in Serum

    Showing 1–10 of 87

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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