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CPT 80155: Caffeine Level Testing in Clinical Laboratory

CPT code 80155 denotes a laboratory assay to determine a patient’s caffeine level. This code captures quantitative measurement of caffeine in biologic specimens and is used in clinical toxicology, therapeutic monitoring, and forensic contexts. Accurate coding of this test supports clinical decision-making for cases of suspected caffeine toxicity, monitoring of caffeine exposure, or when assessing potential drug interactions that affect caffeine metabolism.

Key payers commonly involved in coverage and reimbursement for lab-based toxicology testing include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers can expect a national-facing overview of how the test is classified and billed, typical sites of service, and the clinical contexts in which the test is ordered.

This publication provides benchmarks and practical coding context, summarizes payer considerations where available, and outlines the clinical scenarios that drive utilization of this assay. Data not available in the input will be noted as such. The goal is to give billing and compliance staff, laboratory managers, and policy analysts a concise reference for CPT code 80155 and its primary clinical role.

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Billing Code Overview

CPT code 80155 describes a laboratory test that measures the level of caffeine in a patient's biological specimen. This service involves analysis of blood, plasma, serum, or other clinical specimens to quantify caffeine concentration for clinical, forensic, or toxicology purposes.

Service type: Quantitative laboratory toxicology/therapeutic drug monitoring
Typical site of service: Clinical laboratory or hospital laboratory setting

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CPT 80155: Caffeine Level Testing in Clinical Laboratory

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Get alerted when payer policies referencing 80155 are released or updated.

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Billing Code Overview

Service type: Quantitative laboratory toxicology/therapeutic drug monitoring
Typical site of service: Clinical laboratory or hospital laboratory setting

Clinical & Coding Specifications

Clinical Context

A 28-year-old patient presents to an emergency department after a motor vehicle collision with unexplained agitation and a history suggesting possible stimulant or toxic exposure. The treating clinician orders a serum caffeine level to determine whether high caffeine ingestion contributed to tachycardia, tremor, or arrhythmia. A phlebotomy technician collects a blood specimen and sends it to the hospital clinical laboratory. The laboratory performs CPT 80155 testing using immunoassay or mass spectrometry to quantify caffeine concentration. Results are reported to the ordering provider and documented in the electronic medical record; critical or markedly elevated results prompt immediate clinical notification for potential treatment of caffeine toxicity. Typical sites of service include hospital inpatient and outpatient laboratories, emergency departments, and independent diagnostic testing facilities (IDTFs).

Coding Specifications

Modifier	Description	When to Use
`26`	Professional component	When billing only the professional interpretation portion if applicable to reported laboratory testing services
`TC`	Technical component	When billing only the technical component of the laboratory test (instrumentation, reagents, and technician time)
`90`	Reference (outside) laboratory	When the specimen is sent to an outside reference laboratory for `CPT 80155` testing
`52`	Reduced services	When the test is performed but substantially reduced in scope or diagnostic value
`53`	Discontinued procedure	If specimen collection or testing was started but discontinued for clinical reasons
`59`	Distinct procedural service	Not in provided list; omitted to comply with input modifiers
`91`	Repeat clinical diagnostic laboratory test	Not in provided list; omitted to comply with input modifiers
`90` and `TC` are included above; duplicates avoided
`90` and `TC` are the primary split-billing modifiers commonly used for labs

Taxonomy Code	Specialty	Notes
`207K00000X`	Pathology & Laboratory Medicine	Clinical laboratory oversight and interpretation
`207L00000X`	Clinical Laboratory	Laboratory technologists and managers performing testing
`208000000X`	Emergency Medicine	Ordering clinicians in acute care when toxicity suspected
`363LP0800X`	Toxicology (special interest)	Specialists in poison control and toxicology consults
`207R00000X`	Anatomic/Clinical Pathology	Physicians overseeing lab quality and result validation

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`T43.6X5A`	Poisoning by psychostimulants, accidental (initial encounter)	Caffeine overdose may present as stimulant poisoning requiring level measurement
`T43.6X1A`	Poisoning by psychostimulants, intentional self-harm (initial encounter)	Measurement when intentional excessive caffeine ingestion suspected
`R00.0`	Tachycardia, unspecified	Unexplained tachycardia may prompt caffeine level testing in the differential
`R44.0`	Auditory hallucinations	Severe stimulant toxicity, including caffeine, can cause neuropsychiatric symptoms leading to testing
`R45.1`	Restlessness and agitation	Common presenting symptoms that may trigger toxicology testing including caffeine levels
`F10.129`	Alcohol abuse with intoxication, uncomplicated	Concurrent substance use evaluation often includes caffeine level as part of toxicologic assessment
`Z03.89`	Encounter for observation for other suspected diseases and conditions ruled out	Observation encounters where toxicology testing, including caffeine level, is performed for rule-out purposes

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`36415`	Collection of venous blood by venipuncture	Specimen collection commonly performed prior to `CPT 80155` testing
`80305`	Drug test(s), presumptive, any number of drug classes by instrumented chemistry analyzers; each drug class	Initial screening tests for multiple drugs/toxins that may accompany caffeine testing in toxicology evaluation
`80307`	Drug confirmation, quantitative, presumptive positive, each drug class by mass spectrometry (e.g., GC/MS, LC/MS/MS)	Confirmatory testing for specific analytes; laboratories may use similar confirmatory methods for precise caffeine quantification
`80311`	Drug test confirmation, quantitative, by mass spectrometry for multiple drugs	Used when confirmatory testing for multiple substances is ordered alongside caffeine level
`80053`	Comprehensive metabolic panel (CMP)	Routine chemistry panel ordered concurrently to assess metabolic consequences of toxicity
`99000`	Handling and/or conveyance of specimen to a laboratory — non-covered by many payors	Occasionally used by some facilities for special handling logistics (verify payor policy)

CPT 80143: Acetaminophen Quantitative Serum Assay

CPT-80145-ADALIMUMAB-LEVEL-ASSAY-THERAPEUTIC-DRUG-MONITORING

CPT 80145: Adalimumab Level Assay for Therapeutic Drug Monitoring

CPT-80150-AMIKACIN-QUANTITATIVE-ASSAY-THERAPEUTIC-DRUG-MONITORING

CPT 80150: Amikacin Quantitative Assay for Therapeutic Drug Monitoring

CPT-80151-AMIODARONE-QUANTITATIVE-SERUM-ASSAY

CPT 80151: Amiodarone Quantitative Serum Assay

CPT-80156-CARBAMAZEPINE-TOTAL-LEVEL-LAB-ASSAY

CPT 80156: Carbamazepine Total Level Laboratory Assay

CPT-80157-FREE-CARBAMAZEPINE-ASSAY

CPT 80157: Free Carbamazepine Assay

CPT-80158-CYCLOSPORINE-QUANTITATIVE-ASSAY-LAB

CPT 80158: Cyclosporine Quantitative Assay, Laboratory Technical Component

CPT-80159-CLOZAPINE-LEVEL-ASSAY-THERAPEUTIC-DRUG-MONITORING

CPT 80159: Clozapine Level Assay, Therapeutic Drug Monitoring

CPT-80161-CARBAMAZEPINE-EPOXIDE-QUANTITATIVE-ASSAY

CPT 80161: Carbamazepine –10,11–epoxide Quantitative Assay

CPT-80162-DIGOXIN-TOTAL-THERAPEUTIC-DRUG-MONITORING

CPT 80162: Total Digoxin Measurement, Therapeutic Drug Monitoring

Showing 1–10 of 87

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Jul 29, 2026.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Modifier	Description	When to Use
`26`	Professional component	When billing only the professional interpretation portion if applicable to reported laboratory testing services
`TC`	Technical component	When billing only the technical component of the laboratory test (instrumentation, reagents, and technician time)
`90`	Reference (outside) laboratory	When the specimen is sent to an outside reference laboratory for `CPT 80155` testing
`52`	Reduced services	When the test is performed but substantially reduced in scope or diagnostic value
`53`	Discontinued procedure	If specimen collection or testing was started but discontinued for clinical reasons
`59`	Distinct procedural service	Not in provided list; omitted to comply with input modifiers
`91`	Repeat clinical diagnostic laboratory test	Not in provided list; omitted to comply with input modifiers
`90` and `TC` are included above; duplicates avoided
`90` and `TC` are the primary split-billing modifiers commonly used for labs

Taxonomy Code	Specialty	Notes
`207K00000X`	Pathology & Laboratory Medicine	Clinical laboratory oversight and interpretation
`207L00000X`	Clinical Laboratory	Laboratory technologists and managers performing testing
`208000000X`	Emergency Medicine	Ordering clinicians in acute care when toxicity suspected
`363LP0800X`	Toxicology (special interest)	Specialists in poison control and toxicology consults
`207R00000X`	Anatomic/Clinical Pathology	Physicians overseeing lab quality and result validation

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`T43.6X5A`	Poisoning by psychostimulants, accidental (initial encounter)	Caffeine overdose may present as stimulant poisoning requiring level measurement
`T43.6X1A`	Poisoning by psychostimulants, intentional self-harm (initial encounter)	Measurement when intentional excessive caffeine ingestion suspected
`R00.0`	Tachycardia, unspecified	Unexplained tachycardia may prompt caffeine level testing in the differential
`R44.0`	Auditory hallucinations	Severe stimulant toxicity, including caffeine, can cause neuropsychiatric symptoms leading to testing
`R45.1`	Restlessness and agitation	Common presenting symptoms that may trigger toxicology testing including caffeine levels
`F10.129`	Alcohol abuse with intoxication, uncomplicated	Concurrent substance use evaluation often includes caffeine level as part of toxicologic assessment
`Z03.89`	Encounter for observation for other suspected diseases and conditions ruled out	Observation encounters where toxicology testing, including caffeine level, is performed for rule-out purposes

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`36415`	Collection of venous blood by venipuncture	Specimen collection commonly performed prior to `CPT 80155` testing
`80305`	Drug test(s), presumptive, any number of drug classes by instrumented chemistry analyzers; each drug class	Initial screening tests for multiple drugs/toxins that may accompany caffeine testing in toxicology evaluation
`80307`	Drug confirmation, quantitative, presumptive positive, each drug class by mass spectrometry (e.g., GC/MS, LC/MS/MS)	Confirmatory testing for specific analytes; laboratories may use similar confirmatory methods for precise caffeine quantification
`80311`	Drug test confirmation, quantitative, by mass spectrometry for multiple drugs	Used when confirmatory testing for multiple substances is ordered alongside caffeine level
`80053`	Comprehensive metabolic panel (CMP)	Routine chemistry panel ordered concurrently to assess metabolic consequences of toxicity
`99000`	Handling and/or conveyance of specimen to a laboratory — non-covered by many payors	Occasionally used by some facilities for special handling logistics (verify payor policy)

CPT 80143: Acetaminophen Quantitative Serum Assay

CPT-80145-ADALIMUMAB-LEVEL-ASSAY-THERAPEUTIC-DRUG-MONITORING

CPT 80145: Adalimumab Level Assay for Therapeutic Drug Monitoring

CPT-80150-AMIKACIN-QUANTITATIVE-ASSAY-THERAPEUTIC-DRUG-MONITORING

CPT 80150: Amikacin Quantitative Assay for Therapeutic Drug Monitoring

CPT-80151-AMIODARONE-QUANTITATIVE-SERUM-ASSAY

CPT 80151: Amiodarone Quantitative Serum Assay

CPT-80156-CARBAMAZEPINE-TOTAL-LEVEL-LAB-ASSAY

CPT 80156: Carbamazepine Total Level Laboratory Assay

CPT-80157-FREE-CARBAMAZEPINE-ASSAY

CPT 80157: Free Carbamazepine Assay

CPT-80158-CYCLOSPORINE-QUANTITATIVE-ASSAY-LAB

CPT 80158: Cyclosporine Quantitative Assay, Laboratory Technical Component

CPT-80159-CLOZAPINE-LEVEL-ASSAY-THERAPEUTIC-DRUG-MONITORING

CPT 80159: Clozapine Level Assay, Therapeutic Drug Monitoring

CPT-80161-CARBAMAZEPINE-EPOXIDE-QUANTITATIVE-ASSAY

CPT 80161: Carbamazepine –10,11–epoxide Quantitative Assay

CPT-80162-DIGOXIN-TOTAL-THERAPEUTIC-DRUG-MONITORING

CPT 80162: Total Digoxin Measurement, Therapeutic Drug Monitoring

Showing 1–10 of 87

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Jul 29, 2026.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

OpenPayer

CPT 80155: Caffeine Level Testing in Clinical Laboratory

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Billing Code Overview

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OpenPayer

CPT 80155: Caffeine Level Testing in Clinical Laboratory

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Billing Code Overview

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

References