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    v1.0.30
    OpenPayerBilling CodesOther Diagnostic Nuclear Medicine ProceduresCPT cpt-78808-radiotracer-injection-gamma-probe-localization
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    CPT 78808: Radioguided Localization with Intravenous Radiotracer

    Medicare pays $43 on average nationally for this procedure.

    CPT code 78808 describes intravenous injection of a gamma‑emitting radioactive tracer with intraoperative localization of a structure using a handheld gamma probe; service type: radioguided localization; typical site of service: imaging suite or operating room where nuclear medicine–guided localization is performed.

    For related coverage guidance, see recent payer policy updates: Vafseo (vadadustat) for anemia in CKD on dialysis, Metabolic Disorders - Cysteamine (Oral) Products for Individual and Family Plans, Kerendia (finerenone) — Coverage Criteria.

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    Table of contents

    Progress1 / 7

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a 55-year-old woman with early-stage breast cancer scheduled for lumpectomy with sentinel lymph node mapping. On the morning of surgery, the nuclear medicine team injects a gamma–emitting radiotracer intravenously, and the surgeon uses a handheld gamma probe intraoperatively to localize sentinel lymph nodes for removal. The clinical workflow begins with preoperative planning and informed consent, radiotracer preparation and administration by nuclear medicine or radiology staff, and timing coordinated so tracer uptake is optimal at the time of surgery. In the operating room, the surgeon uses the gamma probe to identify radioactive hotspots corresponding to sentinel nodes; the nodes are excised and sent to pathology. Post-procedure documentation includes the injected radiotracer, dose, injection site, time of injection, probe findings, nodes removed, and any immediate complications. Typical sites of service are hospital operating rooms and ambulatory surgery centers.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    78808Radiopharmaceutical localization of a structure using a gamma probe (intravenous tracer)Primary procedure describing IV injection of gamma–emitting tracer and intraoperative localization with a handheld gamma probe
    38525Biopsy or excision of lymph node(s); open, deep axillary node(s)Often performed when sentinel lymph nodes localized with the gamma probe are surgically excised
    38900Intraoperative identification (e.g., intraoperative lymphatic mapping)Related intraoperative mapping procedures; may be reported when additional mapping techniques are used
    78800Radiopharmaceutical localization of a lesion or tumor, single day imaging (planar)Preoperative localization imaging that may be performed by nuclear medicine to complement intraoperative probe localization
    77370Special medical radiation physics consultation, implementation, and quality assuranceMay be performed when specialized radiotracer handling, dose calibration, or equipment QA is required

    Related Modifiers

    11 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    54Modifier ‑54 (“Surgical care only”) is appended to a CPT surgical procedure when the reporting surgeon performs the intraoperative (surgical) component but does not furnish the preoperative and/or…- Use modifier -54 when the reporting surgeon provided only the intraoperative (surgical) component of a procedure and preoperative and/or postoperative management has been or will be provided by…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Showing 1–10 of 11

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    2084P0800X
    207R00000X
    163WX0106X
    226300000X
    364SX0204X
    2085D0003X
    251K00000X
    261QR0400X

    Related ICD-10-CM Codes

    22 rows

    ICD-10-CM CodeDescription
    C34.90Malignant neoplasm of unspecified part of unspecified bronchus or lung
    C34.91Malignant neoplasm of unspecified part of right bronchus or lung
    C34.92Malignant neoplasm of unspecified part of left bronchus or lung
    C44.91Basal cell carcinoma of skin, unspecified
    C44.92Squamous cell carcinoma of skin, unspecified
    C49.9Malignant neoplasm of connective and soft tissue, unspecified
    C50.911Malignant neoplasm of unspecified site of right female breast
    C50.912Malignant neoplasm of unspecified site of left female breast
    C50.919Malignant neoplasm of unspecified site of unspecified female breast
    C77.0Secondary and unspecified malignant neoplasm of lymph nodes of head, face and neck

    Showing 1–10 of 22

    Related Payer Policy Updates

    Specialty: Nephrology1 / 3

    10 rows

    PolicyPayerEffective Date
    Vafseo (vadadustat) for anemia in CKD on dialysisCigna2026-08-15
    Metabolic Disorders - Cysteamine (Oral) Products for Individual and Family PlansCigna2026-08-15
    Kerendia (finerenone) — Coverage CriteriaBlue Cross Blue Shield - Iowa2026-08-05
    Voyxact (sibeprenlimab-szsl) — Prior authorization / medical necessity for primary IgA nephropathyColorado Rocky Mountain Health Plans2026-08-01
    Oxlumo (lumasiran) and Rivfloza (nedosiran) — Coverage Criteria (Ohio)Colorado Rocky Mountain Health Plans2026-08-01
    Korsuva (difelikefalin) — Medical Benefit Drug Coverage Criteria (Ohio)Colorado Rocky Mountain Health Plans2026-08-01
    Complement Inhibitors - EmpaveliCigna2026-08-01
    Tolvaptan (Jynarque)Cigna2026-08-01
    Nephrology - Filspari (sparsentan) coverageCigna2026-08-01
    Rivfloza (nedosiran) prior authorization for PH1UnitedHealthcare2026-08-01

    Related Codes

    CPT-78800-PLANAR-NUCLEAR-MEDICINE-SINGLE-AREA-TUMOR-LOCALIZATION

    CPT 78800: Planar Nuclear Medicine Imaging, Single Area

    CPT-78801-MULTI-DAY-MULTI-AREA-NUCLEAR-MEDICINE-IMAGING

    CPT 78801: Multi-Day/Multi-Area Nuclear Medicine Tumor Localization

    CPT-78802-WHOLE-BODY-NUCLEAR-MEDICINE-IMAGING

    CPT 78802: Whole-Body Nuclear Medicine Imaging for Tumor/Inflammation Localization

    CPT-78803-SPECT-SINGLE-AREA-LOCALIZATION

    CPT 78803: Single-Day SPECT Tumor/Tracer Localization

    CPT-78804-MULTIDAY-WHOLE-BODY-NUCLEAR-IMAGING-GAMMA-TRACER

    CPT 78804: Whole-Body Nuclear Medicine Imaging, Multi-Day

    CPT-78811-TARGETED-PET-LOCALIZED-BODY-REGION

    CPT 78811: PET, limited area imaging

    CPT-78812-FDG-PET-BODY-IMAGING-FOR-ONCOLOGIC-EVALUATION

    CPT 78812: FDG PET Imaging for Detection of Malignant Tumors

    CPT-78813-WHOLE-BODY-PET

    CPT 78813: PET Whole Body Scan

    CPT-78814-PET-CT-TUMOR-LOCALIZATION-METABOLIC-EVALUATION

    CPT 78814: PET/CT Tumor Localization and Metabolic Imaging

    CPT-78815-PET-CT-TUMOR-IMAGING-ANATOMICAL-LOCALIZATION

    CPT 78815: PET/CT Tumor Imaging with Anatomical Localization

    Showing 1–10 of 16

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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