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    v1.0.30
    OpenPayerBilling CodesDiagnostic Nuclear Medicine Procedures on the Respiratory SystemCPT cpt-78598-pulmonary-ventilation-perfusion-quantitative-scan
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    CPT 78598: Quantitative Pulmonary Ventilation and Perfusion Scan

    Medicare pays $184 on average nationally for this procedure.

    CPT code 78598 describes a combined pulmonary ventilation and perfusion nuclear medicine scan performed to quantitatively assess differential ventilation and perfusion within the lungs; this diagnostic imaging service is a quantitative V/Q study typically provided in an outpatient imaging center or hospital nuclear medicine department and involves radiotracer administration with imaging to evaluate regional air flow and blood flow for clinical assessment of pulmonary function and suspected embolic or obstructive processes.

    For related coverage guidance, see recent payer policy updates: Vafseo (vadadustat) for anemia in CKD on dialysis, Metabolic Disorders - Cysteamine (Oral) Products for Individual and Family Plans, Kerendia (finerenone) — Coverage Criteria.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 67-year-old patient with a history of chronic obstructive pulmonary disease and new-onset unilateral pleuritic chest pain presents with unexplained dyspnea and an elevated clinical suspicion for pulmonary embolism. The referring pulmonologist or emergency physician orders a quantitative ventilation–perfusion nuclear medicine study to evaluate regional ventilation and perfusion and to identify or exclude perfusion defects consistent with pulmonary embolism. The patient arrives at an outpatient nuclear medicine or hospital radiology department. The nuclear medicine technologist obtains informed consent, reviews allergies and pregnancy status, and performs a ventilation scan (commonly using inhaled radiotracer such as Technegas or aerosolized radioaerosol) followed by a perfusion scan (intravenous injection of macroaggregated albumin labeled with technetium-99m). Images are acquired in multiple projections and processed for quantitative analysis of differential pulmonary ventilation and perfusion. A radiologist or nuclear medicine physician interprets the combined study, documents quantitative findings (including percentage perfusion by lung or lobe), and issues a report that guides clinical management such as anticoagulation decisions or further imaging like CT pulmonary angiography. Typical sites of service include hospital outpatient departments, hospital inpatient wards, and freestanding or hospital-based nuclear medicine suites. Service type: diagnostic nuclear medicine ventilation–perfusion (V/Q) study involving both ventilation and perfusion components.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    71020Radiologic examination, chest, 2 viewsOften used before or after V/Q studies to assess chest anatomy or alternative causes of symptoms.
    71260Computed tomography, thorax; with contrast material(s)CT pulmonary angiography is a common adjunct or alternative when V/Q results are nondiagnostic or when anatomic detail is required.
    78800Radiopharmaceutical therapy/diagnostic; administration (intravenous)Covers intravenous administration of radiopharmaceuticals such as Tc-99m MAA used in the perfusion component (note: billing conventions vary by facility).
    88361Pathology consultation/quantitative immunohistochemistry — note: not typically used for imagingData not applicable; included only if ancillary quantitative tissue analysis is performed, which is uncommon.
    71010Chest radiograph, single viewMay be ordered as an initial imaging screen in the workflow prior to V/Q scanning.

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208000000X
    207K00000X
    207L00000X
    208D00000X
    367A00000X
    207XP3100X
    152W00000X
    246X00000X

    Related ICD-10-CM Codes

    27 rows

    ICD-10-CM CodeDescription
    A41.9Sepsis, unspecified organism
    B97.89Other viral agents as the cause of diseases classified elsewhere
    C34.90Malignant neoplasm of unspecified part of unspecified bronchus or lung
    D68.9Coagulation defect, unspecified
    E66.9Obesity, unspecified
    I26.90Septic pulmonary embolism without acute cor pulmonale
    I26.92Saddle embolus of pulmonary artery without acute cor pulmonale
    I26.99Other pulmonary embolism without acute cor pulmonale
    I27.0Primary pulmonary hypertension
    I27.89Other specified pulmonary heart diseases

    Showing 1–10 of 27

    Related Payer Policy Updates

    Specialty: Nephrology1 / 3

    10 rows

    PolicyPayerEffective Date
    Vafseo (vadadustat) for anemia in CKD on dialysisCigna2026-08-15
    Metabolic Disorders - Cysteamine (Oral) Products for Individual and Family PlansCigna2026-08-15
    Kerendia (finerenone) — Coverage CriteriaBlue Cross Blue Shield - Iowa2026-08-05
    Voyxact (sibeprenlimab-szsl) — Prior authorization / medical necessity for primary IgA nephropathyColorado Rocky Mountain Health Plans2026-08-01
    Oxlumo (lumasiran) and Rivfloza (nedosiran) — Coverage Criteria (Ohio)Colorado Rocky Mountain Health Plans2026-08-01
    Korsuva (difelikefalin) — Medical Benefit Drug Coverage Criteria (Ohio)Colorado Rocky Mountain Health Plans2026-08-01
    Complement Inhibitors - EmpaveliCigna2026-08-01
    Tolvaptan (Jynarque)Cigna2026-08-01
    Nephrology - Filspari (sparsentan) coverageCigna2026-08-01
    Rivfloza (nedosiran) prior authorization for PH1UnitedHealthcare2026-08-01

    Related Codes

    CPT-78579-PULMONARY-VENTILATION-IMAGING-NUCLEAR-SCAN

    CPT 78579: Pulmonary Ventilation Imaging

    CPT-78580-PULMONARY-PERFUSION-NUCLEAR-IMAGING

    CPT 78580: Lung Perfusion Nuclear Imaging for Pulmonary Embolism

    CPT-78582-PULMONARY-VENTILATION-AND-PERFUSION-NUCLEAR-SCAN

    CPT 78582: Pulmonary Ventilation and Perfusion Nuclear Scan

    CPT-78597-PULMONARY-PERFUSION-QUANTITATIVE-NUCLEAR-SCAN

    CPT 78597: Pulmonary Perfusion Quantitative Blood Flow

    CPT-78599-UNLISTED-RESPIRATORY-NUCLEAR-MEDICINE-PROCEDURE

    CPT 78599: Respiratory Diagnostic Nuclear Medicine, Unlisted Procedure

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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