Find policies, billing codes, payers, states, and providers

CPT 78580: Pulmonary Perfusion Nuclear Imaging

CPT code 78580 denotes a combined technical and professional nuclear perfusion imaging study of the lungs used to assess pulmonary blood flow and identify perfusion defects such as pulmonary embolism. This diagnostic imaging code is significant nationally because it supports acute evaluation of suspected pulmonary embolism, informs clinical decision-making in emergency and inpatient settings, and impacts utilization patterns for advanced imaging services across payers. Key payers covered in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will gain a concise clinical and billing overview of CPT code 78580, including its role in diagnostic pathways for suspected pulmonary embolism, typical sites of service, and common billing contexts. The publication also summarizes benchmark considerations and recent payer policy themes relevant to nuclear pulmonary perfusion imaging. Data not available in the input is noted where present-day specifics (such as associated taxonomies or typical ICD-10 pairings) are not provided.

Customize your policy alerts

Sign up for cpt 78580 policy alerts

Get alerted when payer policies referencing 78580 are released or updated.

Monitor payer policy activity

Receive email alerts as soon as relevant payer policies are published or updated.

Billing Code Overview

CPT code 78580 describes a nuclear perfusion imaging study of the lungs performed to evaluate pulmonary blood flow and detect perfusion defects, such as those caused by pulmonary embolism. The procedure includes both image acquisition with radiopharmaceuticals and interpretation by the provider when billed for the combined technical and professional components.

Service type: Diagnostic nuclear medicine study — pulmonary perfusion imaging

Typical site of service: Hospital outpatient imaging department, hospital inpatient imaging, or outpatient radiology/nuclear medicine facility

Data not available in the input for associated taxonomies, ICD-10 diagnoses, and related codes.

Find policies, billing codes, payers, states, and providers

CPT 78580: Pulmonary Perfusion Nuclear Imaging

Customize your policy alerts

Sign up for cpt 78580 policy alerts

Get alerted when payer policies referencing 78580 are released or updated.

Monitor payer policy activity

Receive email alerts as soon as relevant payer policies are published or updated.

Billing Code Overview

Service type: Diagnostic nuclear medicine study — pulmonary perfusion imaging

Typical site of service: Hospital outpatient imaging department, hospital inpatient imaging, or outpatient radiology/nuclear medicine facility

Data not available in the input for associated taxonomies, ICD-10 diagnoses, and related codes.

Clinical & Coding Specifications

Clinical Context

A 58-year-old patient presents to the emergency department with acute onset dyspnea, pleuritic chest pain, tachycardia, and an oxygen saturation of 90% on room air. D-dimer is elevated and clinical assessment raises concern for pulmonary embolism. The clinician orders a nuclear medicine lung perfusion scan to evaluate regional pulmonary blood flow and identify potential perfusion defects consistent with emboli. The patient is transported to the nuclear medicine department where a technologist administers the radiopharmaceutical, acquires perfusion images in multiple projections, and the interpreting nuclear medicine physician reviews the images, generates a report, and documents findings in the medical record. The procedure is performed in a hospital outpatient radiology/nuclear medicine suite; it may also occur in an inpatient imaging department. The billed service includes both technical (radiopharmaceutical, technologist time, image acquisition) and professional (interpretation, report) components under 78580.

Coding Specifications

Modifier	Description	When to Use
`26`	Professional component	Use when billing only the physician interpretation portion; technical component billed by facility separately.
`TC`	Technical component	Use when billing only the facility/technical portion; physician bills separately for `26`.
`59`	Distinct procedural service	Use when a separate, unrelated procedure is performed on the same day that is not normally bundled with the perfusion study.
`52`	Reduced services	Use when the study is partially performed or limited (e.g., incomplete acquisition due to patient intolerance).
`53`	Discontinued procedure	Use when the procedure is started but discontinued due to emergency or patient condition.
`76`	Repeat procedure by same physician	Use when the same physician repeats the perfusion scan same day for a documented reason.
`77`	Repeat procedure by another physician	Use when another physician repeats the study on same day.
`90`	Reference (Outside) laboratory	Use when an outside imaging facility performed the technical component and results are sent for billing (if applicable in local payer rules).
`62`	Two surgeons (co-surgeons)	Rare for this nuclear study but available when two physicians of different specialties share responsibility for the interpretation under specific payer policies.
`50`	Bilateral procedure	Not typically applicable but included when a payer requires notation for bilateral-related studies (use per payer guidance).

Taxonomy Code	Specialty	Notes
2085P0800X	Nuclear Medicine Physician	Interprets and reports perfusion imaging; primary specialty for `78580`.
207RC0000X	Radiology	Radiologists with nuclear medicine training commonly perform and interpret lung perfusion studies.
2084N0400X	Cardiology	Cardiology imaging specialists may order and interpret scans when assessing thromboembolic disease in cardiopulmonary context.
340600000X	Emergency Medicine	Emergency physicians commonly initiate the diagnostic pathway and order the study for acute presentations.
363L00000X	Pulmonary Disease	Pulmonologists frequently order and co-manage patients undergoing lung perfusion imaging.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`I26.99`	Other pulmonary embolism without acute cor pulmonale	Primary indication for lung perfusion imaging to detect pulmonary emboli.
`I26.90`	Pulmonary embolism without acute cor pulmonale, unspecified	Common diagnostic code used when perfusion imaging is performed to evaluate suspected PE.
`R06.02`	Shortness of breath	Symptom prompting imaging to assess for causes including pulmonary embolism.
`R07.9`	Chest pain, unspecified	Pleuritic or non-specific chest pain may lead to ordering a perfusion scan.
`R79.1`	Abnormal coagulation profile	Coagulopathy or elevated D-dimer may trigger further imaging evaluation for embolic disease.
`J98.4`	Other disorders of lung, not elsewhere classified	Used when perfusion defects suggest non-thromboembolic causes requiring further evaluation.
`Z03.818`	Encounter for observation for other suspected diseases and conditions ruled out	Used when patient is observed while awaiting imaging results such as a perfusion study.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`71260`	Computed tomography, chest; without contrast material	Often performed as an alternate or complementary study when CT pulmonary angiography is used to evaluate for pulmonary embolism.
`71045`	Radiologic examination, chest; single view, frontal	Initial chest radiograph frequently obtained before or alongside perfusion imaging to assess alternate causes of dyspnea.
`78466`	Myocardial imaging, planar or SPECT, single study, rest or stress; first study of a two-day protocol	In patients with cardiopulmonary symptoms, myocardial perfusion studies may be performed in the same workflow to assess cardiac ischemia (separate service).
`G0237`	Diagnostic imaging service, radiopharmaceutical localization of pulmonary perfusion	Medicare-specific HCPCS sometimes used for reporting certain perfusion imaging; relates as alternative coding in some payer systems.
`93740`	Phlebotomy and immediate interpretation (pulmonary embolism workup)	Laboratory and diagnostic tests, such as D-dimer and other imaging, are part of the clinical pathway surrounding `78580`.

CPT 78579: Pulmonary Ventilation Imaging (Nuclear Scan)

CPT-78582-PULMONARY-VENTILATION-AND-PERFUSION-NUCLEAR-SCAN

CPT 78582: Pulmonary Ventilation and Perfusion Nuclear Scan

CPT-78597-PULMONARY-PERFUSION-QUANTITATIVE-NUCLEAR-SCAN

CPT 78597: Pulmonary Perfusion Quantitative Nuclear Scan

CPT-78598-PULMONARY-VENTILATION-PERFUSION-QUANTITATIVE-SCAN

CPT 78598: Pulmonary Ventilation and Perfusion Quantitative Scan

CPT-78599-UNLISTED-RESPIRATORY-NUCLEAR-MEDICINE-PROCEDURE

CPT 78599: Unlisted Respiratory Diagnostic Nuclear Medicine Procedure

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Jul 29, 2026.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Modifier	Description	When to Use
`26`	Professional component	Use when billing only the physician interpretation portion; technical component billed by facility separately.
`TC`	Technical component	Use when billing only the facility/technical portion; physician bills separately for `26`.
`59`	Distinct procedural service	Use when a separate, unrelated procedure is performed on the same day that is not normally bundled with the perfusion study.
`52`	Reduced services	Use when the study is partially performed or limited (e.g., incomplete acquisition due to patient intolerance).
`53`	Discontinued procedure	Use when the procedure is started but discontinued due to emergency or patient condition.
`76`	Repeat procedure by same physician	Use when the same physician repeats the perfusion scan same day for a documented reason.
`77`	Repeat procedure by another physician	Use when another physician repeats the study on same day.
`90`	Reference (Outside) laboratory	Use when an outside imaging facility performed the technical component and results are sent for billing (if applicable in local payer rules).
`62`	Two surgeons (co-surgeons)	Rare for this nuclear study but available when two physicians of different specialties share responsibility for the interpretation under specific payer policies.
`50`	Bilateral procedure	Not typically applicable but included when a payer requires notation for bilateral-related studies (use per payer guidance).

Taxonomy Code	Specialty	Notes
2085P0800X	Nuclear Medicine Physician	Interprets and reports perfusion imaging; primary specialty for `78580`.
207RC0000X	Radiology	Radiologists with nuclear medicine training commonly perform and interpret lung perfusion studies.
2084N0400X	Cardiology	Cardiology imaging specialists may order and interpret scans when assessing thromboembolic disease in cardiopulmonary context.
340600000X	Emergency Medicine	Emergency physicians commonly initiate the diagnostic pathway and order the study for acute presentations.
363L00000X	Pulmonary Disease	Pulmonologists frequently order and co-manage patients undergoing lung perfusion imaging.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`I26.99`	Other pulmonary embolism without acute cor pulmonale	Primary indication for lung perfusion imaging to detect pulmonary emboli.
`I26.90`	Pulmonary embolism without acute cor pulmonale, unspecified	Common diagnostic code used when perfusion imaging is performed to evaluate suspected PE.
`R06.02`	Shortness of breath	Symptom prompting imaging to assess for causes including pulmonary embolism.
`R07.9`	Chest pain, unspecified	Pleuritic or non-specific chest pain may lead to ordering a perfusion scan.
`R79.1`	Abnormal coagulation profile	Coagulopathy or elevated D-dimer may trigger further imaging evaluation for embolic disease.
`J98.4`	Other disorders of lung, not elsewhere classified	Used when perfusion defects suggest non-thromboembolic causes requiring further evaluation.
`Z03.818`	Encounter for observation for other suspected diseases and conditions ruled out	Used when patient is observed while awaiting imaging results such as a perfusion study.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`71260`	Computed tomography, chest; without contrast material	Often performed as an alternate or complementary study when CT pulmonary angiography is used to evaluate for pulmonary embolism.
`71045`	Radiologic examination, chest; single view, frontal	Initial chest radiograph frequently obtained before or alongside perfusion imaging to assess alternate causes of dyspnea.
`78466`	Myocardial imaging, planar or SPECT, single study, rest or stress; first study of a two-day protocol	In patients with cardiopulmonary symptoms, myocardial perfusion studies may be performed in the same workflow to assess cardiac ischemia (separate service).
`G0237`	Diagnostic imaging service, radiopharmaceutical localization of pulmonary perfusion	Medicare-specific HCPCS sometimes used for reporting certain perfusion imaging; relates as alternative coding in some payer systems.
`93740`	Phlebotomy and immediate interpretation (pulmonary embolism workup)	Laboratory and diagnostic tests, such as D-dimer and other imaging, are part of the clinical pathway surrounding `78580`.

CPT 78579: Pulmonary Ventilation Imaging (Nuclear Scan)

CPT-78582-PULMONARY-VENTILATION-AND-PERFUSION-NUCLEAR-SCAN

CPT 78582: Pulmonary Ventilation and Perfusion Nuclear Scan

CPT-78597-PULMONARY-PERFUSION-QUANTITATIVE-NUCLEAR-SCAN

CPT 78597: Pulmonary Perfusion Quantitative Nuclear Scan

CPT-78598-PULMONARY-VENTILATION-PERFUSION-QUANTITATIVE-SCAN

CPT 78598: Pulmonary Ventilation and Perfusion Quantitative Scan

CPT-78599-UNLISTED-RESPIRATORY-NUCLEAR-MEDICINE-PROCEDURE

CPT 78599: Unlisted Respiratory Diagnostic Nuclear Medicine Procedure

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Jul 29, 2026.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

OpenPayer

CPT 78580: Pulmonary Perfusion Nuclear Imaging

Sign up for cpt 78580 policy alerts

Billing Code Overview

Catch payer policy changes before they impact reimbursement

Catch payer policy changes before they impact reimbursement

OpenPayer

CPT 78580: Pulmonary Perfusion Nuclear Imaging

Sign up for cpt 78580 policy alerts

Billing Code Overview

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

References