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    v1.0.30
    OpenPayerBilling CodesDiagnostic Nuclear Medicine Procedures on the Cardiovascular SystemCPT cpt-78430-pet-myocardial-perfusion-imaging-rest-or-stress
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    CPT 78430: PET Myocardial Perfusion Imaging with CT

    Medicare pays $76 on average nationally for this procedure.

    CPT code 78430 describes a PET myocardial perfusion imaging study with CT transmission that assesses regional blood flow to the heart and can include ejection fraction and ventricular wall motion analysis when performed; this service is a nuclear cardiology perfusion imaging study typically provided in an outpatient imaging center, hospital radiology/nuclear medicine department, or cardiac catheterization lab setting and can be performed at rest or during pharmacologic or exercise stress testing.

    For related coverage guidance, see recent payer policy updates: Automated Ambulatory Blood Pressure Monitoring for Diagnosis of Hypertension in Patients with Elevated Office Blood Pressure, Cardiology - Ivabradine, Cardiac Computed Tomography (CCT)/Coronary Computed Tomographic Angiography (CCTA).

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    Clinical & Coding Specifications

    Clinical Context

    A 64-year-old male with a history of ischemic heart disease, prior percutaneous coronary intervention, and exertional angina is referred for a PET myocardial perfusion imaging study (78430) to assess regional myocardial blood flow and viability. The patient arrives fasting; baseline vitals and IV access are obtained. A radiopharmaceutical (commonly rubidium-82 or N-13 ammonia) is administered at rest and then during pharmacologic stress (e.g., regadenoson) or exercise if feasible. A combined PET with CT transmission scan is performed to acquire attenuation-corrected perfusion images. Left ventricular ejection fraction and ventricular wall motion are measured during the study if acquired. The interpreting physician reviews the PET images, CT attenuation data, and quantitative perfusion/ejection fraction results, documents findings and impression, and generates a report for the referring cardiologist.

    Typical site of service: outpatient nuclear medicine suite, hospital-based imaging center, or cardiac catheterization department with PET capability.

    Service type: diagnostic cardiac PET myocardial perfusion imaging with CT transmission (single study at rest or with stress).

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    71020Radiologic examination, chest; single view, frontalPre-procedure or adjunct chest radiograph when needed for clinical assessment before PET/CT.
    75571Magnetic resonance (e.g., cardiac MRI) for morphology and function without contrastAlternative or complementary modality for cardiac function and viability assessment.
    78452Myocardial SPECT imaging, single study, at rest and/or stress - tomographic (SPECT)Alternative nuclear myocardial perfusion study often performed when PET is not available.
    93000Electrocardiogram, routine ECG with interpretation and reportPerformed before or during stress testing to monitor cardiac rhythm.
    CPT code data not available in the inputData not available in the input.Data not available in the input.

    Related Modifiers

    10 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    24Modifier 24 denotes an unrelated evaluation and management (E/M) service performed by the same physician or qualified healthcare professional during a postoperative global period. Per CPT guidance,…- Use modifier 24 when you report an evaluation and management (E/M) service performed by the same physician or same-specialty group during a procedure’s postoperative global period that is unrelated…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RC0000X
    2084N0402X
    363AM0700X
    2083A0100X
    183500000X
    111NI0900X
    273100000X
    207PT0002X

    Related Payer Policy Updates

    Specialty: Cardiology1 / 2

    10 rows

    PolicyPayerEffective Date
    Automated Ambulatory Blood Pressure Monitoring for Diagnosis of Hypertension in Patients with Elevated Office Blood PressureBluecross Idaho2026-11-01
    Cardiology - IvabradineCigna2026-10-15
    Cardiac Computed Tomography (CCT)/Coronary Computed Tomographic Angiography (CCTA)univerahealthcare2026-10-15
    Percutaneous Ventricular Assist DeviceUnitedHealthcare2026-10-01
    Cardiovascular Disease Risk AssessmentOscar Health2026-10-01
    Biomarkers for Myocardial Infarction and Chronic Heart FailureOscar Health2026-10-01
    Multiple Procedure Payment Reduction for Diagnostic Cardiovascular ProceduresBlue Cross Blue Shield - Maine2026-10-01
    Left Atrial Appendage Closure Devicesexcellus_health_plan_inc2026-09-17
    Left Atrial Appendage Closure Devicesuniverahealthcare2026-09-17
    Cardiac Omnibus CodesCigna2026-09-15

    Related Codes

    CPT-78414-CARDIAC-PERFUSION-BLOOD-FLOW-ASSESSMENT

    CPT 78414: Cardiac Perfusion and Ejection Fraction Assessment

    CPT-78428-LEFT-TO-RIGHT-CARDIAC-SHUNT-DETECTION

    CPT 78428: Detection of Left-to-Right Cardiac Shunt

    CPT-78429-PET-MYOCARDIAL-IMAGING-PET-CT-MYOCARDIUM-FUNCTION

    CPT 78429: PET Myocardial Imaging, Single Study

    CPT-78431-PET-MYOCARDIAL-PERFUSION-IMAGING-REST-AND-STRESS

    CPT 78431: PET Myocardial Perfusion with CT Transmission, Rest and Stress

    CPT-78432-PET-MYOCARDIAL-PERFUSION-METABOLIC-VIABILITY

    CPT 78432: PET Myocardial Perfusion and Viability Imaging

    CPT-78433-PET-MYOCARDIAL-PERFUSION-METABOLIC-IMAGING-CT

    CPT 78433: PET Myocardial Imaging for Perfusion and Metabolism

    CPT-78434-PET-MYOCARDIAL-PERFUSION-REST-AND-STRESS

    CPT 78434: PET Myocardial Blood Flow Study, Rest and Stress

    CPT-78445-ANGIOGRAPHY-VENOGRAPHY-DIAGNOSTIC-VASCULAR-IMAGING

    CPT 78445: Angiography/Venography Blood Flow Imaging

    CPT-78451-SINGLE-SPECT-MYOCARDIAL-PERFUSION-STUDY

    CPT 78451: Myocardial Perfusion SPECT, Single Study

    CPT-78452-CARDIAC-PERFUSION-SPECT-MULTIPLE-STUDIES

    CPT 78452: Myocardial Perfusion SPECT, Multiple Studies

    Showing 1–10 of 28

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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