CPT code 78429 denotes a PET myocardial imaging study with a CT transmission scan used to evaluate myocardial metabolism and function. This single-study nuclear cardiology procedure provides metabolic information—such as oxygen or glucose utilization—and may include measurements of ejection fraction and ventricular wall motion. The code is nationally relevant due to the growing role of PET in assessing ischemia, viability, and advanced cardiac metabolic assessment, and because PET myocardial studies have implications for cardiac care pathways and imaging utilization.

Key payers covered in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of the clinical context for PET myocardial imaging, typical sites of service, and service line implications. The publication summarizes common billing and documentation themes for CPT code 78429, highlights payer coverage considerations at a national level, and outlines areas where policy updates or clinical guidance may affect utilization. The content is intended to inform coding, billing oversight, and administrative planning for facilities and payers involved in advanced cardiac imaging.