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    v1.0.30
    OpenPayerBilling CodesDiagnostic Nuclear Medicine Procedures on the Gastrointestinal SystemCPT cpt-78226-hepatobiliary-scintigraphy-hepatobiliary-imaging
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    CPT 78226: Hepatobiliary Scintigraphy (Hepatobiliary Imaging)

    Medicare pays $198 on average nationally for this procedure.

    CPT code 78226 describes hepatobiliary scintigraphy in which the provider images the liver, bile, bile ducts, and gallbladder to follow production and flow of bile for evaluation of bile duct obstruction or leakage, biliary abnormalities, cholecystitis, gallstones, or other hepatobiliary disorders; this is a nuclear medicine diagnostic imaging service typically performed in an outpatient imaging center, hospital radiology or nuclear medicine department, or specialized clinic to assess hepatobiliary function and biliary drainage into the small intestine.

    For related coverage guidance, see recent payer policy updates: Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disorders, Esophagogastroduodenoscopy (EGD) Coverage Policy, Radiofrequency Therapy for Fecal Incontinence.

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    Clinical & Coding Specifications

    Clinical Context

    A 52-year-old female presents to the outpatient nuclear medicine department with persistent right upper quadrant abdominal pain, intermittent fever, and abnormal liver function tests suggestive of cholestasis. The clinician orders a hepatobiliary scintigraphy to evaluate gallbladder function and to detect acute cholecystitis, cystic duct obstruction, or bile leak following recent laparoscopic cholecystectomy. The patient arrives fasting, intravenous access is obtained, and a radiopharmaceutical (commonly Tc-99m labeled iminodiacetic acid derivative) is administered. Dynamic and delayed planar images are acquired over the liver, biliary tree, gallbladder, and small bowel per the nuclear medicine protocol. If visualization of the gallbladder is delayed or absent, pharmacologic stimulation with morphine or cholecystokinin may be used per protocol. Imaging results are interpreted by the nuclear medicine physician, and a report documenting tracer uptake, biliary excretion, gallbladder visualization, ejection fraction if performed, and any evidence of bile leak or obstruction is generated and routed to the referring surgeon or hepatologist for further management.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    78226Hepatobiliary scintigraphy; imaging of liver, bile, bile ducts, and gallbladder to follow bile production and flowPrimary procedure — used to diagnose bile duct obstruction, bile leak, acute cholecystitis, gallstones, and other hepatobiliary disorders
    78227Hepatobiliary scintigraphy with evaluation of gallbladder ejection fraction (CCK stimulation)Often performed adjunctively when assessment of gallbladder contractility/ejection fraction is clinically indicated during the same imaging session
    78800Radiopharmaceutical localization of tumor; simple planar imaging (general nuclear medicine)Related nuclear medicine imaging code category used for other planar scintigraphic studies; may be used for additional or alternative nuclear studies
    76536Ultrasonography, transabdominal, real time with image documentation; limited or focused (e.g., biliary tract)Commonly performed before or after scintigraphy to evaluate gallbladder wall thickness, stones, or biliary dilation
    47562Laparoscopy, surgical, cholecystectomySurgical procedure related to management when hepatobiliary scintigraphy demonstrates pathology requiring operative intervention

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    2084P0800X
    207RC0000X
    207L00000X
    363A00000X
    251F00000X
    207KI0005X
    261QE0700X
    261QA3000X

    Related Payer Policy Updates

    Specialty: Gastroenterology1 / 3

    10 rows

    PolicyPayerEffective Date
    Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disordersbcbsvermont2026-12-01
    Esophagogastroduodenoscopy (EGD) Coverage Policyevicore2026-11-05
    Radiofrequency Therapy for Fecal IncontinenceCigna2026-10-15
    Magnetic Sphincter Augmentation for the Treatment of Gastroesophageal Reflux Disease (GERD)univerahealthcare2026-10-15
    High-Resolution Anoscopy (HRA)Premera Bluecross2026-10-01
    Gastroesophageal and Gastrointestinal (GI) Services and ProceduresColorado Rocky Mountain Health Plans2026-10-01
    Serum Testing for Hepatic Fibrosis in the Evaluation and Monitoring of Chronic Liver DiseaseOscar Health2026-10-01
    Fecal Analysis in the Diagnosis of Intestinal Dysbiosis and Fecal Microbiota Transplant TestingOscar Health2026-10-01
    Pancreatic Enzyme Testing for Acute PancreatitisOscar Health2026-10-01
    Helicobacter pylori TestingOscar Health2026-10-01

    Related Codes

    CPT-78201-LIVER-SPLEEN-SCAN-DIAGNOSTIC-NUCLEAR-MEDICINE

    CPT 78201: Liver and Spleen Scan

    CPT-78202-LIVER-SPLEEN-SCAN-NUCLEAR-MEDICINE

    CPT 78202: Liver and Spleen Scan

    CPT-78215-LIVER-SPLEEN-SCAN-NUCLEAR-MEDICINE

    CPT 78215: Liver and Spleen Scan, Diagnostic Nuclear Medicine

    CPT-78216-LIVER-SPLEEN-SCAN-DIAGNOSTIC-IMAGING

    CPT 78216: Liver and Spleen Scan

    CPT-78227-HEPATOBILIARY-SCINTIGRAPHY-LIVER-BILE-GALLBLADDER-IMAGING

    CPT 78227: Hepatobiliary (Cholescintigraphy) Scan

    CPT-78230-SALIVARY-GLAND-NUCLEAR-IMAGING

    CPT 78230: Salivary Gland Imaging with Radiotracer

    CPT-78231-SALIVARY-GLAND-NUCLEAR-IMAGING-SERIAL-IMAGES

    CPT 78231: Salivary Gland Scintigraphy, Serial Imaging

    CPT-78232-SALIVARY-GLAND-SCINTIGRAPHY-PAROTID-FUNCTION

    CPT 78232: Salivary Gland Scintigraphy (Parotid Gland Scan)

    CPT-78258-ESOPHAGEAL-TRANSIT-SCINTIGRAPHY-ESOPHAGEAL-MOTILITY-STUDY

    CPT 78258: Esophageal Transit Scintigraphy

    CPT-78261-GASTRIC-MUCOSA-RADIONUCLIDE-IMAGING

    CPT 78261: Gastric Mucosa Nuclear Imaging

    Showing 1–10 of 21

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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