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    v1.0.30
    OpenPayerBilling CodesDiagnostic Nuclear Medicine Procedures on the Endocrine SystemCPT cpt-78075-functional-adrenal-nuclear-imaging
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    CPT 78075: Functional Adrenal Imaging with Radiotracer

    Medicare pays $270 on average nationally for this procedure.

    CPT code 78075 describes a functional adrenal imaging study in which a radiolabeled cholesterol or radioactive tracer is injected intravenously and the patient returns for delayed imaging within three to seven days to evaluate and identify abnormal adrenal function; this service is a nuclear medicine functional imaging procedure typically ordered by endocrine or nuclear medicine specialists and performed in an outpatient imaging center or hospital nuclear medicine department.

    For related coverage guidance, see recent payer policy updates: Diabetic Supplies, Radiofrequency Ablation for Thyroid Nodules, Continuous Glucose Monitoring and Insulin Delivery for Managing Diabetes (for Idaho Only).

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a 45–65-year-old adult referred by endocrinology for evaluation of possible primary hyperaldosteronism or ACTH-independent Cushing syndrome after biochemical testing (e.g., elevated plasma aldosterone-to-renin ratio or abnormal dexamethasone suppression testing). The provider administers an intravenous radiolabeled cholesterol or other adrenal-specific radioactive tracer and provides the patient with written instructions and any prescribed oral medications (such as dexamethasone, potassium supplementation, or antihypertensive adjustments) to take prior to scheduled imaging. The patient returns 3–7 days later for single-photon emission computed tomography (SPECT) or planar scintigraphic imaging of the adrenal glands to localize functional adrenal tissue or hormone-producing nodules. Typical workflow: outpatient nuclear medicine consult and injection visit, patient education and medication scheduling, interval medication administration at home as instructed, and delayed imaging appointment at the nuclear medicine or radiology department. Typical site of service is an outpatient hospital radiology/nuclear medicine department or an independent imaging center with nuclear medicine capability. Common clinical reasons include lateralization of aldosterone secretion, characterization of adrenal incidentalomas with suspected hormonal activity, and localization of adrenal cortical carcinoma or adenoma prior to surgical planning.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    78800Radiopharmaceutical localization of tumor or distribution of radiopharmaceutical, planar, with or without tomographic (SPECT) imaging; single day imagingAlternative radiopharmaceutical localization studies that may be used when immediate imaging is performed the same day rather than delayed imaging; sometimes used for non-cholesterol tracers.
    78803Radionuclide imaging, tomographic (SPECT); single studySPECT imaging code commonly reported for tomographic acquisition when SPECT is performed as part of the delayed adrenal imaging session.
    96372Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscularUsed when documenting administration of adjunctive medications at the facility (note: nuclear radiopharmaceutical injection is separately coded by radionuclide imaging codes).
    78014Thyroid uptake and imaging (planar)Related nuclear medicine procedure in endocrine evaluation workflows; not for adrenal imaging but may be performed in parallel endocrine nuclear studies.
    78195Renal cortical imaging, planar; staticAnother endocrine-related nuclear study that may be ordered in complex endocrine workups; demonstrates association of radionuclide imaging procedures in endocrine localization workflows.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    81Modifier -81 indicates a physician served as a minimal assistant surgeon for part—not all—of an operative procedure. Use when a physician’s assisting role is limited and does not represent full…- Use CPT modifier -81 when a physician acts as a minimum assistant surgeon who assists during only part (a limited portion) of an operative procedure; append -81 to the primary surgical CPT code to…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208C00000X
    207L00000X
    207RH0000X
    163W00000X
    133VN1101X
    103TE1100X
    207RH0002X
    335V00000X

    Related Payer Policy Updates

    Specialty: Endocrinology1 / 3

    10 rows

    PolicyPayerEffective Date
    Diabetic SuppliesCigna2026-10-15
    Radiofrequency Ablation for Thyroid NodulesCigna2026-10-15
    Continuous Glucose Monitoring and Insulin Delivery for Managing Diabetes (for Idaho Only)UnitedHealthcare2026-10-01
    Tzield (teplizumab-mzwv) CoverageUnitedHealthcare2026-10-01
    Continuous Glucose Monitoring and Insulin Delivery for Managing Diabetes (for Indiana Only)UnitedHealthcare2026-10-01
    Medical Necessity Guidelines Insulin PumpsMass General Brigham Health Plan2026-10-01
    Medical Necessity Guidelines: Continuous Glucose MonitorsMass General Brigham Health Plan2026-10-01
    Continuous Glucose MonitoringAmbetter Nevada2026-10-01
    Salivary Hormone TestingOscar Health2026-10-01
    Bone Turnover Markers TestingOscar Health2026-10-01

    Related Codes

    CPT-78012-THYROID-RADIOIODINE-UPTAKE-STUDY

    CPT 78012: Radioiodine Thyroid Uptake, 4–24 Hour

    CPT-78013-THYROID-RADIOIODINE-IMAGING-UPTAKE

    CPT 78013: Thyroid Scintigraphy with Radioiodine Imaging

    CPT-78014-THYROID-RADIOIODINE-UPTAKE-IMAGING

    CPT 78014: Thyroid Radioiodine Uptake and Imaging

    CPT-78015-THYROID-SCAN-NUCLEAR-MEDICINE

    CPT 78015: Thyroid Scan, Nuclear Medicine

    CPT-78016-THYROID-SCAN-NUCLEAR-MEDICINE-IMAGING

    CPT 78016: Thyroid Scan, Nuclear Medicine

    CPT-78018-THYROID-SCAN-NUCLEAR-MEDICINE-IMAGING

    CPT 78018: Thyroid Scan, Radionuclide Imaging

    CPT-78020-THYROID-SCAN-NUCLEAR-MEDICINE

    CPT 78020: Thyroid Scan, Nuclear Medicine

    CPT-78070-PARATHYROID-DUAL-TRACER-IMAGING-SUBTRACTION-STUDY

    CPT 78070: Parathyroid Imaging with Dual Tracer/Subtraction

    CPT-78071-SPECT-PARATHYROID-IMAGING-DUAL-TRACER

    CPT 78071: SPECT Parathyroid Imaging with Planar/Subtraction Study

    CPT-78072-PARATHYROID-NUCLEAR-MEDICINE-SPECT-CT-LOCALIZATION

    CPT 78072: Parathyroid Nuclear Medicine Imaging with SPECT/CT

    Showing 1–10 of 11

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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