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    v1.0.30
    OpenPayerBilling CodesDiagnostic Nuclear Medicine Procedures on the Endocrine SystemCPT cpt-78070-parathyroid-dual-tracer-imaging-subtraction-study
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    CPT 78070: Parathyroid Imaging with Dual Tracer/Subtraction

    Medicare pays $182 on average nationally for this procedure.

    CPT code 78070 describes a parathyroid imaging study in which the provider acquires two sets of images after administering two different radiopharmaceutical tracers, then normalizes and compares the image sets and may perform subtraction processing to localize abnormal parathyroid tissue; this is a diagnostic nuclear medicine service typically performed by a nuclear medicine or radiology provider as an outpatient imaging procedure or hospital-based imaging study.

    For related coverage guidance, see recent payer policy updates: Diabetic Supplies, Radiofrequency Ablation for Thyroid Nodules, Continuous Glucose Monitoring and Insulin Delivery for Managing Diabetes (for Idaho Only).

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 56-year-old patient with hypercalcemia and elevated parathyroid hormone (PTH) presents for localization of suspected parathyroid adenoma prior to surgical consultation. The patient is referred from endocrinology after biochemical confirmation of primary hyperparathyroidism and intermittent neck ultrasound that is inconclusive. The nuclear medicine team administers two small doses of different radiopharmaceuticals (commonly sestamibi and pertechnetate or a dual-phase dual-tracer technique), acquires images at appropriate time points, performs image normalization and comparison, and may perform digital subtraction to highlight focal increased radiotracer uptake in a parathyroid gland. Images and a written report are provided to the referring surgeon and endocrinologist for preoperative planning. Typical workflow includes patient intake and consent, tracer administration, timed imaging acquisition, image processing/subtraction, and interpretation by a board-certified nuclear medicine physician. Typical site of service is an outpatient imaging center, hospital nuclear medicine department, or ambulatory surgical center when used for preoperative localization. Typical service type is diagnostic nuclear medicine imaging with image post-processing and interpretation.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    78014Thyroid uptake and imaging (static)Alternative or complementary nuclear medicine imaging when thyroid evaluation is needed alongside parathyroid localization.
    78100Thyroid uptake, single quantitative measurementMay be ordered to assess thyroid function which can affect interpretation of parathyroid imaging.
    78800Radiopharmaceutical localization of tumor or distribution of radiopharmaceutical (planar)General category for planar nuclear localization studies; conceptually related methodology.
    78803Unlisted nuclear medicine procedure (planar or SPECT)Used when imaging or processing is not described by a specific code; rarely used if dual-tracer subtraction technique is unique.
    78830Tissue imaging using positron emission tomography (PET), single areaNot routinely used for parathyroid but may be relevant if advanced localization (e.g., 18F-fluorocholine PET) is performed in challenging cases.

    Related Modifiers

    11 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…

    Showing 1–10 of 11

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208D00000X
    208000000X
    207K00000X
    103TA0400X
    207ZI0100X
    2084B0002X
    261QM2800X
    171R00000X

    Related ICD-10-CM Codes

    26 rows

    ICD-10-CM CodeDescription
    C75.0Malignant neoplasm of parathyroid gland
    D44.3Neoplasm of uncertain behavior of pituitary gland
    E00.9Congenital iodine-deficiency syndrome, unspecified
    E02Subclinical iodine-deficiency hypothyroidism
    E03.9Hypothyroidism, unspecified
    E05.90Thyrotoxicosis, unspecified without thyrotoxic crisis or storm
    E10.9Type 1 diabetes mellitus without complications
    E11.9Type 2 diabetes mellitus without complications
    E21.0Primary hyperparathyroidism
    E21.1Secondary hyperparathyroidism, not elsewhere classified

    Showing 1–10 of 26

    Related Payer Policy Updates

    Specialty: Endocrinology1 / 3

    10 rows

    PolicyPayerEffective Date
    Diabetic SuppliesCigna2026-10-15
    Radiofrequency Ablation for Thyroid NodulesCigna2026-10-15
    Continuous Glucose Monitoring and Insulin Delivery for Managing Diabetes (for Idaho Only)UnitedHealthcare2026-10-01
    Tzield (teplizumab-mzwv) CoverageUnitedHealthcare2026-10-01
    Continuous Glucose Monitoring and Insulin Delivery for Managing Diabetes (for Indiana Only)UnitedHealthcare2026-10-01
    Medical Necessity Guidelines Insulin PumpsMass General Brigham Health Plan2026-10-01
    Medical Necessity Guidelines: Continuous Glucose MonitorsMass General Brigham Health Plan2026-10-01
    Continuous Glucose MonitoringAmbetter Nevada2026-10-01
    Salivary Hormone TestingOscar Health2026-10-01
    Bone Turnover Markers TestingOscar Health2026-10-01

    Related Codes

    CPT-78012-THYROID-RADIOIODINE-UPTAKE-STUDY

    CPT 78012: Radioiodine Thyroid Uptake, 4–24 Hour

    CPT-78013-THYROID-RADIOIODINE-IMAGING-UPTAKE

    CPT 78013: Thyroid Scintigraphy with Radioiodine Imaging

    CPT-78014-THYROID-RADIOIODINE-UPTAKE-IMAGING

    CPT 78014: Thyroid Radioiodine Uptake and Imaging

    CPT-78015-THYROID-SCAN-NUCLEAR-MEDICINE

    CPT 78015: Thyroid Scan, Nuclear Medicine

    CPT-78016-THYROID-SCAN-NUCLEAR-MEDICINE-IMAGING

    CPT 78016: Thyroid Scan, Nuclear Medicine

    CPT-78018-THYROID-SCAN-NUCLEAR-MEDICINE-IMAGING

    CPT 78018: Thyroid Scan, Radionuclide Imaging

    CPT-78020-THYROID-SCAN-NUCLEAR-MEDICINE

    CPT 78020: Thyroid Scan, Nuclear Medicine

    CPT-78071-SPECT-PARATHYROID-IMAGING-DUAL-TRACER

    CPT 78071: SPECT Parathyroid Imaging with Planar/Subtraction Study

    CPT-78072-PARATHYROID-NUCLEAR-MEDICINE-SPECT-CT-LOCALIZATION

    CPT 78072: Parathyroid Nuclear Medicine Imaging with SPECT/CT

    CPT-78075-FUNCTIONAL-ADRENAL-NUCLEAR-IMAGING

    CPT 78075: Functional Adrenal Imaging with Radiotracer

    Showing 1–10 of 11

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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