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    v1.0.30
    OpenPayerBilling CodesRadiation Treatment DeliveryCPT cpt-77425-intraoperative-electron-beam-radiation-technical
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    CPT 77425: Intraoperative Electron Beam Therapy, Technical Component

    CPT code 77425 describes the technical component of delivering intraoperative electron beam radiation therapy, a procedure in which an electron irradiating beam is administered directly to an exposed tumor during surgery; service type: intraoperative radiation therapy (IORT) technical service; typical site of service: operating room or surgical suite where the radiation delivery equipment is used to treat the tumor intraoperatively.

    For related coverage guidance, see recent payer policy updates: Radiation oncology coverage and treatment delivery guidelines, Proton Beam Therapy, Radiation and Oncologic Procedures.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 64-year-old patient with a previously diagnosed cutaneous or soft-tissue malignancy of the chest wall is taken to the operating room for surgical resection. Intraoperative frozen section confirms clear margins are difficult to obtain and the multidisciplinary team elects to deliver intraoperative electron beam radiation (IOERT) directly to the tumor bed immediately after resection to reduce local recurrence risk. The patient is positioned on the operating table, sterile technique is maintained, and the radiation oncology team brings a mobile linear accelerator or dedicated IOERT applicator into the OR. Protective shielding is placed for surrounding normal tissues and the applicator is positioned over the exposed tumor bed. The radiation therapist and medical physicist set dose, energy, and applicator size under direction of the radiation oncologist. The technical component staff operate the irradiating electron beam and perform machine setup, dosimetry verification, QA checks, and documentation of delivered dose while the surgeon temporarily closes or retracts tissues as required. After delivery of the electron beam, the surgical team completes closure and the patient is transferred to recovery. Billing for the technical component of the intraoperative electron beam procedure is reported with 77425 for the facility/technical services associated with delivering IOERT.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    77425Intraoperative radiation treatment using electron beam; technical component onlyThis is the technical component code used by the facility or technical provider to report delivery of IOERT electron beam to the tumor bed.
    77334Plan; radiation therapy, dose planning — simple (one or two fields)Used for preoperative or intraoperative dose planning when a simple plan is created to guide IOERT delivery.
    77336Radiation treatment devices, design and construction; bolus, shielding, or immobilization deviceUsed when custom shielding or applicators are designed or fabricated to protect normal tissues during IOERT.
    77261Therapeutic radiology simulation-aided field and dose planning; simpleUsed for simulation or field verification related to planning intraoperative electron beam parameters.
    77470Special medical radiation physics consultation, when performedUsed for complex dosimetry, physics consultation, or special calculations related to IOERT planning and delivery.
    55875Laparoscopy, surgical; radical prostatectomy, retropubic or perineal, including nerve sparing when performed (example of concurrent surgical code)Represents an example of a concurrent major surgical procedure where IOERT might be administered in the OR during oncologic resections (surgical code billed by surgeon; IOERT billed separately).

    Note: If additional institution- or payer-specific codes are used for intraoperative services (e.g., anesthesia, facility charges), they are reported separately according to standard billing practices.

    Related Modifiers

    11 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    73Modifier 73 indicates a facility-level outpatient hospital or ASC procedure that was discontinued after the patient was prepared and taken to the procedure/operating room but before any anesthesia…- When to use: Apply CPT modifier 73 on the FACILITY (outpatient hospital or ASC) claim when the patient has been fully prepared and physically taken into the procedure/operating room but the…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    56Modifier ‑56 indicates the reporting provider furnished only the preoperative management for a surgical procedure and did not perform the intraoperative or postoperative care. It is used in…- Use Modifier -56 when a provider performs only the preoperative management in a split‑care situation (one physician manages preop care while a different physician performs the intraoperative…

    Showing 1–10 of 11

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207K00000X
    3336C0002X
    103TA0700X
    225200000X
    2471S1302X
    207Q00000X
    2080P0205X
    2080P0202X

    Related Payer Policy Updates

    Specialty: Radiation Oncology1 / 2

    10 rows

    PolicyPayerEffective Date
    Radiation oncology coverage and treatment delivery guidelinesevicore2026-11-05
    Proton Beam Therapyuniversityofutahhealthplans2026-10-25
    Radiation and Oncologic ProceduresUnitedHealthcare2026-09-01
    Electronic Brachytherapy for Nonmelanoma Skin CancerBluecross Idaho2026-07-30
    Surface Radiation Therapy for Treatment of Non-Melanoma Skin Cancereocco2026-07-09
    Radiofrequency Ablation of Tumors Outside the LiverProvidence Health Plan2026-07-01
    Therapeutic Radiopharmaceuticals in Oncology (Lutathera, Pluvicto, Xofigo) Coverage CriteriaBlue Cross Blue Shield - North Carolina2026-07-01
    Intensity Modulated Radiation TherapyAmbetter Georgia2026-06-01
    Irreversible Electroporation (IRE) of Tumors Other Than LiverBlue Cross Blue Shield - Rhode Island2026-06-01
    Irreversible Electroporation (IRE) — NanoKnife (Preauthorization Required)Blue Cross Blue Shield - Nebraska2026-06-01

    Related Codes

    CPT-77402-EXTERNAL-BEAM-RADIATION-THERAPY-LEVEL-1

    CPT 77402: External Beam Radiation Therapy, Level 1 Complexity

    CPT-77407-3D-CRT-IMRT-SINGLE-ISOCENTER-LEVEL-2

    CPT 77407: Radiation Therapy, Level 2 Complexity

    CPT-77412-EXTERNAL-BEAM-RADIATION-THERAPY-HIGH-COMPLEXITY

    CPT 77412: Complex External Beam Radiation Delivery

    CPT-77417-THERAPEUTIC-RADIOLOGY-PORT-FILMS

    CPT 77417: Therapeutic Radiology Port Films

    CPT-77424-INTRAOPERATIVE-RADIATION-THERAPY-TECHNICAL-COMPONENT

    CPT 77424: Intraoperative Radiation Therapy, Technical Component

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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