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    v1.0.30
    OpenPayerBilling CodesRadiation Treatment DeliveryCPT cpt-77424-intraoperative-radiation-therapy-technical-component
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    CPT 77424: Intraoperative Radiation Therapy, Technical Component

    CPT code 77424 describes the technical component of intraoperative radiation therapy, where radiation in the form of irradiating X‑rays is delivered directly to an exposed tumor during surgery; service type: intraoperative radiation therapy technical component; typical site of service: operating room or procedure suite during a surgical procedure.

    For related coverage guidance, see recent payer policy updates: Radiation oncology coverage and treatment delivery guidelines, Proton Beam Therapy, Radiation and Oncologic Procedures.

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    Table of contents

    Progress1 / 7

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a 62-year-old with a localized breast or head and neck malignancy scheduled for intraoperative radiation therapy (IORT) using electron or low-energy X‑ray delivery directly to the tumor bed at the time of surgery. The patient arrives to the operating room under general anesthesia for tumor resection (lumpectomy or surgical excision). After the surgeon achieves hemostasis and exposes the tumor bed, the radiation oncology team positions the applicator and delivers a single high-dose fraction of radiation while the patient remains in the sterile field. The procedure documented by 77424 represents the technical component of delivering irradiating X‑rays intraoperatively. Post‑delivery, the applicator is removed, the surgeon completes reconstructive steps, and the patient is transferred to recovery with routine postoperative monitoring. Typical workflow includes preoperative radiation oncology planning, intraoperative setup and dosimetry verification, real‑time delivery of therapy (technical service), and postoperative documentation of dose and any acute effects.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    33405Resection, tumor, cardiac (example code — placeholder)Data not available in the input.
    77334Radiation treatment device simulation or localization of a radiation field using imagingPerformed preoperatively or intraoperatively to localize the target for IORT planning and setup.
    77470Special medical radiation physics consultation, including complex treatment planningUsed when complex dosimetry or special physics consultation is required for IORT setup.
    77290Therapeutic radiology simulation-aided field setup and documentationSupports planning and documentation of treatment geometry for intraoperative delivery.
    76937Ultrasound guidance for placement of radiation deviceMay be used intraoperatively for applicator placement guidance when ultrasound is employed.

    Related Modifiers

    12 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    73Modifier 73 indicates a facility-level outpatient hospital or ASC procedure that was discontinued after the patient was prepared and taken to the procedure/operating room but before any anesthesia…- When to use: Apply CPT modifier 73 on the FACILITY (outpatient hospital or ASC) claim when the patient has been fully prepared and physically taken into the procedure/operating room but the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    82Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…

    Showing 1–10 of 12

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207T00000X
    207L00000X
    225100000X
    163WG0000X
    207PS0010X
    152WV0400X
    247100000X
    122400000X

    Related ICD-10-CM Codes

    26 rows

    ICD-10-CM CodeDescription
    C15.9Malignant neoplasm of esophagus, unspecified
    C18.9Malignant neoplasm of colon, unspecified
    C20Malignant neoplasm of rectum
    C22.0Liver cell carcinoma
    C25.9Malignant neoplasm of pancreas, unspecified
    C33Malignant neoplasm of trachea
    C34.90Malignant neoplasm of unspecified part of unspecified bronchus or lung
    C43.9Malignant melanoma of skin, unspecified
    C50.911Malignant neoplasm of unspecified site of right female breast
    C50.912Malignant neoplasm of unspecified site of left female breast

    Showing 1–10 of 26

    Related Payer Policy Updates

    Specialty: Radiation Oncology1 / 2

    10 rows

    PolicyPayerEffective Date
    Radiation oncology coverage and treatment delivery guidelinesevicore2026-11-05
    Proton Beam Therapyuniversityofutahhealthplans2026-10-25
    Radiation and Oncologic ProceduresUnitedHealthcare2026-09-01
    Electronic Brachytherapy for Nonmelanoma Skin CancerBluecross Idaho2026-07-30
    Surface Radiation Therapy for Treatment of Non-Melanoma Skin Cancereocco2026-07-09
    Radiofrequency Ablation of Tumors Outside the LiverProvidence Health Plan2026-07-01
    Therapeutic Radiopharmaceuticals in Oncology (Lutathera, Pluvicto, Xofigo) Coverage CriteriaBlue Cross Blue Shield - North Carolina2026-07-01
    Intensity Modulated Radiation TherapyAmbetter Georgia2026-06-01
    Irreversible Electroporation (IRE) of Tumors Other Than LiverBlue Cross Blue Shield - Rhode Island2026-06-01
    Irreversible Electroporation (IRE) — NanoKnife (Preauthorization Required)Blue Cross Blue Shield - Nebraska2026-06-01

    Related Codes

    CPT-77402-EXTERNAL-BEAM-RADIATION-THERAPY-LEVEL-1

    CPT 77402: External Beam Radiation Therapy, Level 1 Complexity

    CPT-77407-3D-CRT-IMRT-SINGLE-ISOCENTER-LEVEL-2

    CPT 77407: Radiation Therapy, Level 2 Complexity

    CPT-77412-EXTERNAL-BEAM-RADIATION-THERAPY-HIGH-COMPLEXITY

    CPT 77412: Complex External Beam Radiation Delivery

    CPT-77417-THERAPEUTIC-RADIOLOGY-PORT-FILMS

    CPT 77417: Therapeutic Radiology Port Films

    CPT-77425-INTRAOPERATIVE-ELECTRON-BEAM-RADIATION-TECHNICAL

    CPT 77425: Intraoperative Electron Beam Therapy, Technical Component

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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