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    v1.0.30
    OpenPayerBilling CodesRadiation Treatment DeliveryCPT cpt-77407-3d-crt-imrt-single-isocenter-level-2
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    CPT 77407: Radiation Therapy, Level 2 Complexity

    Medicare pays $325 on average nationally for this procedure.

    CPT code 77407 describes radiation therapy, level 2 complexity, for delivery of three-dimensional conformal radiation therapy (3D CRT) or intensity modulated radiation therapy (IMRT) to a single isocenter with imaging guidance when performed; the service reflects more advanced delivery and conformal targeting than basic 2D techniques and is typically provided as an external beam radiation therapy service in an outpatient radiation oncology clinic or hospital-based radiation therapy suite.

    For related coverage guidance, see recent payer policy updates: Radiation oncology coverage and treatment delivery guidelines, Proton Beam Therapy, Radiation and Oncologic Procedures.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 64-year-old patient with a newly diagnosed, localized prostate adenocarcinoma is referred to radiation oncology for definitive external beam radiation. After multidisciplinary review, the patient undergoes treatment planning including simulation CT with immobilization, contouring of target volumes and organs at risk, and creation of an intensity modulated radiation therapy (IMRT) plan delivered to a single isocenter. Daily image guidance (cone-beam CT or kV imaging) is used for setup verification. The clinical workflow includes simulation and fiduciary or soft-tissue localization, physics plan quality assurance, daily treatment delivery sessions over several weeks, on-treatment visits for toxicity assessment, and periodic follow-up visits to assess response and late effects. The typical site of service is an outpatient radiation oncology clinic or hospital-based radiation therapy department equipped with linear accelerators capable of 3D conformal radiation therapy or IMRT and image-guidance systems.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    77261Therapeutic radiology simulation-aided field settings, simple; includes immobilization and simulation proceduresUsed at initial simulation to create immobilization and define treatment fields prior to IMRT/3DCRT planning
    77301Special radiotherapy simulation, complex; beam data or stereotactic coordinate systemsUsed for complex simulation techniques or special localization that may precede IMRT delivery
    77336Continuing medical physics consultation, including assessment of treatment delivery and plan changesPerformed for physics oversight during IMRT planning and adaptive adjustments
    77370Special medical radiation physics consultation; treatment devices, immobilization, bolusUsed when custom immobilization or bolus devices are created for complex conformal therapy
    77418Radiation treatment delivery, intrafraction motion management or stereotactic body radiation therapy deliveryUsed when advanced delivery or motion management techniques are required in conjunction with IMRT/3DCRT
    G6015Image guidance for localization during radiation therapy delivery (example image-guidance HCPCS/G-code variations by payer)Used to report daily or periodic image-guidance procedures that accompany IMRT delivery

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RH0000X
    332B00000X
    363LW0102X
    207NP0225X
    208VP0000X
    2081P0301X
    1835E0208X
    246QH0401X

    Related ICD-10-CM Codes

    24 rows

    ICD-10-CM CodeDescription
    C18.9Malignant neoplasm of colon, unspecified
    C20Malignant neoplasm of rectum
    C22.0Liver cell carcinoma
    C25.9Malignant neoplasm of pancreas, unspecified
    C34.90Malignant neoplasm of unspecified part of unspecified bronchus or lung
    C43.9Malignant melanoma of skin, unspecified
    C44.91Basal cell carcinoma of skin, unspecified
    C50.911Malignant neoplasm of unspecified site of right female breast
    C50.912Malignant neoplasm of unspecified site of left female breast
    C61Malignant neoplasm of prostate

    Showing 1–10 of 24

    Related Payer Policy Updates

    Specialty: Radiation Oncology1 / 2

    10 rows

    PolicyPayerEffective Date
    Radiation oncology coverage and treatment delivery guidelinesevicore2026-11-05
    Proton Beam Therapyuniversityofutahhealthplans2026-10-25
    Radiation and Oncologic ProceduresUnitedHealthcare2026-09-01
    Electronic Brachytherapy for Nonmelanoma Skin CancerBluecross Idaho2026-07-30
    Surface Radiation Therapy for Treatment of Non-Melanoma Skin Cancereocco2026-07-09
    Radiofrequency Ablation of Tumors Outside the LiverProvidence Health Plan2026-07-01
    Therapeutic Radiopharmaceuticals in Oncology (Lutathera, Pluvicto, Xofigo) Coverage CriteriaBlue Cross Blue Shield - North Carolina2026-07-01
    Intensity Modulated Radiation TherapyAmbetter Georgia2026-06-01
    Irreversible Electroporation (IRE) of Tumors Other Than LiverBlue Cross Blue Shield - Rhode Island2026-06-01
    Irreversible Electroporation (IRE) — NanoKnife (Preauthorization Required)Blue Cross Blue Shield - Nebraska2026-06-01

    Related Codes

    CPT-77402-EXTERNAL-BEAM-RADIATION-THERAPY-LEVEL-1

    CPT 77402: External Beam Radiation Therapy, Level 1 Complexity

    CPT-77412-EXTERNAL-BEAM-RADIATION-THERAPY-HIGH-COMPLEXITY

    CPT 77412: Complex External Beam Radiation Delivery

    CPT-77417-THERAPEUTIC-RADIOLOGY-PORT-FILMS

    CPT 77417: Therapeutic Radiology Port Films

    CPT-77424-INTRAOPERATIVE-RADIATION-THERAPY-TECHNICAL-COMPONENT

    CPT 77424: Intraoperative Radiation Therapy, Technical Component

    CPT-77425-INTRAOPERATIVE-ELECTRON-BEAM-RADIATION-TECHNICAL

    CPT 77425: Intraoperative Electron Beam Therapy, Technical Component

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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