CPT code 65105 represents enucleation: surgical removal of a diseased or damaged eyeball with insertion of an ocular implant and attachment to the extraocular muscles. Nationally, this ophthalmic surgical code is important for clinical management of severe ocular trauma, intraocular malignancy, or end-stage ocular disease when globe removal is indicated. It also affects facility and surgeon billing, prosthetic planning, and postoperative rehabilitation pathways.

Key payers commonly involved in coverage for this procedure include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Payer policies vary on medical necessity criteria, documentation requirements, and coverage of the implant and subsequent prosthetic services.

Readers will learn the clinical context of the procedure, typical sites of service, and the elements that drive coding and billing for enucleation with implant placement. The publication provides benchmarks and policy-relevant considerations for payers, facilities, and clinicians, including how coverage and claims processing can differ across major commercial insurers and Medicare. Data not available in the input is noted where applicable.