CPT code 65101 represents the surgical enucleation of an eyeball, removing a diseased or damaged globe with its contents intact and without placement of an ocular implant. This procedure is clinically significant for treating severe ocular trauma, untreatable ocular disease, or blind painful eyes and has implications for surgical planning, post-operative care, prosthetic rehabilitation, and payer coverage determinations nationwide. Key payers in analyses typically include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare.

Readers will find a concise national overview of clinical context and service delivery for 65101, including common sites of service and how the procedure fits into surgical and prosthetic care pathways. The publication summarizes expected billing practice elements, common modifiers when reported (input provided), and identifies where input data is unavailable. It also outlines the types of benchmarks and policy topics commonly reviewed for this code, such as coverage scope, payment variation across major payers, and implications for facility versus ambulatory settings. Data not available in the input is explicitly noted where applicable.